Gabriel Ortega,Alejandro Chamorro-Garcia,Francesco Ricci et al.
Gabriel Ortega et al.
Cooperativity (homotropic allostery) is the primary mechanism by which evolution steepens the binding curves of biomolecular receptors to produce more responsive input-output behavior in biomolecular systems. Motivated by the ubiquity with ...
Amer Alam,Kaspar P Locher
Amer Alam
ABC transporters are essential for cellular physiology. Humans have 48 ABC genes organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for membrane transporters, of which several are involved in drug ...
Cryo-Electron Tomography: The Resolution Revolution and a Surge of In Situ Virological Discoveries [0.03%]
cryo-electron层析成像：分辨率革命及原位病毒学发现的增加
Ye Hong,Yutong Song,Zheyuan Zhang et al.
Ye Hong et al.
The recent proliferation of cryo-electron tomography (cryo-ET) techniques has led to the cryo-ET resolution revolution. Meanwhile, significant efforts have been made to improve the identification of targets in the cellular context and the t...
Lars V Bock,Sara Gabrielli,Michal H Kolář et al.
Lars V Bock et al.
Large biomolecular systems are at the heart of many essential cellular processes. The dynamics and energetics of an increasing number of these systems are being studied by computer simulations. Pushing the limits of length- and timescales t...
S Walter Englander
S Walter Englander
My accidental encounter with protein hydrogen exchange (HX) at its very beginning and its continued development through my scientific career have led us to a series of advances in HX measurement, interpretation, and cutting edge biophysical...
Assembly and Architecture of NLR Resistosomes and Inflammasomes [0.03%]
NLR Resistosome和炎症小体的组装及结构框架
Zehan Hu,Jijie Chai
Zehan Hu
Nucleotide-binding and leucine-rich repeat (NLR) proteins are critical intracellular immune receptors in both animals and plants. Perception of pathogen-derived or stress-associated signals induces NLR oligomerization to form multiprotein c...
Nattakan Sukomon,Chen Fan,Crina M Nimigean
Nattakan Sukomon
Carefully orchestrated opening and closing of ion channels control the diffusion of ions across cell membranes, generating the electrical signals required for fast transmission of information throughout the nervous system. Inactivation is a...
Bojan Zagrovic,Marlene Adlhart,Thomas H Kapral
Bojan Zagrovic
The mechanism and the evolution of DNA replication and transcription, the key elements of the central dogma of biology, are fundamentally well explained by the physicochemical complementarity between strands of nucleic acids. However, the d...
Critical Assessment of Methods for Predicting the 3D Structure of Proteins and Protein Complexes [0.03%]
蛋白质和蛋白质复合物三维结构预测方法的批判性评估
Shoshana J Wodak,Sandor Vajda,Marc F Lensink et al.
Shoshana J Wodak et al.
Advances in a scientific discipline are often measured by small, incremental steps. In this review, we report on two intertwined disciplines in the protein structure prediction field, modeling of single chains and modeling of complexes, tha...
Christophe Chipot
Christophe Chipot
Efforts to combine theory and experiment to advance our knowledge of molecular processes relevant to biophysics have been considerably enhanced by the contribution of statistical-mechanics simulations. Key to the understanding of such molec...