Soft Modes as a Predictive Framework for Low-Dimensional Biological Systems Across Scales [0.03%]
软模式作为预测跨尺度低维生物系统的框架
Christopher Joel Russo,Kabir Husain,Arvind Murugan
Christopher Joel Russo
All biological systems are subject to perturbations arising from thermal fluctuations, external environments, or mutations. Yet, while biological systems consist of thousands of interacting components, recent high-throughput experiments hav...
Suman Kulkarni,Dani S Bassett
Suman Kulkarni
The brain is immensely complex, with diverse components and dynamic interactions building upon one another to orchestrate a wide range of behaviors. Understanding the patterns of these complex interactions and how they are coordinated to su...
Niels Radmacher,Alexey I Chizhik,Oleksii Nevskyi et al.
Niels Radmacher et al.
Over the last 30 years, fluorescence microscopy, renowned for its sensitivity and specificity, has undergone a revolution in resolving ever-smaller details. This advancement began with stimulated emission depletion (STED) microscopy and pro...
Matthew MacAinsh,Fidha Nazreen Kunnath Muhammedkutty,Ramesh Prasad et al.
Matthew MacAinsh et al.
It is now clear that membrane association of intrinsically disordered proteins or intrinsically disordered regions regulates many cellular processes, such as membrane targeting of Src family kinases and ion channel gating. Residue-specific ...
Jiapeng Wei,Georg Meisl,Alexander J Dear et al.
Jiapeng Wei et al.
Low-molecular-weight oligomers formed from amyloidogenic peptides and proteins have been identified as key cytotoxins across a range of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. Developing therapeut...
Statistical Thermodynamics of the Protein Ensemble: Mediating Function and Evolution [0.03%]
蛋白质系综的统计热力学：功能与进化的媒介作用
Vincent J Hilser,James O Wrabl,Charles E F Millard et al.
Vincent J Hilser et al.
The growing appreciation of native state conformational fluctuations mediating protein function calls for critical reevaluation of protein evolution and adaptation. If proteins are ensembles, does nature select solely for ground state struc...
Gašper Tkačik,Pieter Rein Ten Wolde
Gašper Tkačik
Living systems are characterized by controlled flows of matter, energy, and information. While the biophysics community has productively engaged with the first two, addressing information flows has been more challenging, with some scattered...
Guillaume Romet-Lemonne,Cécile Leduc,Antoine Jégou et al.
Guillaume Romet-Lemonne et al.
The cytoskeleton comprises networks of different biopolymers, which serve various cellular functions. To accomplish these tasks, their mechanical properties are of particular importance. Understanding them requires detailed knowledge of the...
Victor Muñoz,Rama Reddy Goluguri,Catherine Ghosh et al.
Victor Muñoz et al.
Like their prokaryotic counterparts, eukaryotic transcription factors must recognize specific DNA sites, search for them efficiently, and bind to them to help recruit or block the transcription machinery. For eukaryotic factors, however, th...
Shuobo Shi,Yu Chen,Jens Nielsen
Shuobo Shi
Microbial cell factories have been developed to produce various compounds in a sustainable and economically viable manner. The yeast Saccharomyces cerevisiae has been used as a platform cell factory in industrial biotechnology with numerous...