Nonequilibrium Thermodynamics of Biochemical Networks: Energetics of Cellular Functions [0.03%]
生化网络的非平衡热力学-细胞功能的能量学
Yuhai Tu
Yuhai Tu
I review recent advances in nonequilibrium thermodynamics of biochemical networks, organized around two central questions. First, why is free energy dissipation essential for enabling or enhancing biological function? Second, how do energet...
Nikolai Slavov
Nikolai Slavov
Over the last decade, proteomics analysis of single cells by mass spectrometry transitioned from an uncertain possibility to a set of robust and rapidly advancing technologies supporting the accurate quantification of thousands of proteins....
Yao Liu,Xinmeng Gao,Shuo Huang
Yao Liu
Nanopores have become transformative tools in single-molecule chemical analysis, enabling detailed interrogation of molecular interactions and reaction dynamics. These advancements have revolutionized the characterization of chemical kineti...
Kaushik Roy,Aryeh Warmflash
Kaushik Roy
Pattern formation, or the emergence of spatial order and fate specification from initially homogeneous cell populations, is a fundamental problem in developmental biology and biophysics. In vitro cell culture platforms now provide powerful ...
Tethered Signaling Proteins [0.03%]
固着性信号蛋白
Jun Allard,Omer Dushek
Jun Allard
Cells process signals by using large and complex networks of molecules that interact and modify one another. Some of these interactions occur among molecules connected by long flexible tethers, often made of intrinsically disordered protein...
Imaging Dynamic Subcellular Organization at High Spatiotemporal Resolution [0.03%]
高时空分辨动态亚细胞结构与组分成像研究
Francesca W van Tartwijk,Liuba Dvinskikh,Edward N Ward et al.
Francesca W van Tartwijk et al.
The spatiotemporal organization of intracellular compartments is fundamental to cellular function and to the understanding of the processes underpinning health and disease. Fluorescence microscopy offers a powerful means to observe organell...
Ken Halvorsen,Andrew Ward,Wesley P Wong
Ken Halvorsen
Single-molecule techniques have transformed biological research by enabling direct observation and manipulation of individual molecules. These methods overcome ensemble averaging inherent in bulk measurements and facilitate studies under ph...
Size Matters: A Biophysical Perspective on Biomolecular Condensates in Bacteria [0.03%]
大小有影响：细菌生物分子凝聚体的生物物理视角
Lydia Hodgins,Baljyot Singh Parmar,Rodrigo Reyes-Lamothe et al.
Lydia Hodgins et al.
Bacteria are unicellular organisms that typically lack membrane-bound organelles. Nevertheless, they are not merely "bags of enzymes" and instead use alternate mechanisms to organize their components in space and time. Biomolecular condensa...
The Mitochondrial Permeability Transition Pore: Past, Present, and Future [0.03%]
线粒体渗透转换孔通道：过去、现在与将来
Michela Carraro,Christoph Gerle,Paolo Bernardi
Michela Carraro
The mitochondrial permeability transition (PT) is a Ca2+-dependent permeability increase of the inner mitochondrial membrane mediated by opening of a high-conductance channel, the PT pore. Its molecular nature has been the subject of intens...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms [0.03%]
日益壮大的组蛋白家族：非真核生物中的基于组蛋白的DNA组织方式
Alejandro Villalta,Sashi R Weerawarana,Michael L Nosella et al.
Alejandro Villalta et al.
Histones are small basic proteins that form the proteinaceous core of the nucleosome, the repeating building block of chromatin in all eukaryotes. Long thought to be exclusive to eukaryotes, histones are now increasingly appreciated for the...