Pattern Formation Beyond Turing: Physical Principles of Mass-Conserving Reaction-Diffusion Systems [0.03%]
超越图灵模式形成的物理原理：保守型反应扩散系统的基本规律
Erwin Frey,Henrik Weyer
Erwin Frey
Intracellular protein patterns govern essential cellular functions by dynamically redistributing proteins between membrane-bound and cytosolic states, conserving their total numbers. This review presents a theoretical framework for understa...
Kelly Aspinwall,Tyler Hain,M Lisa Manning
Kelly Aspinwall
Rigidity is an emergent property of materials-it is not a feature of individual components that compose the structure, but instead arises from interactions between many constituent parts. It has been recognized that floppy-rigid or fluid-so...
Miguel Antonio Aon,Sonia Cortassa
Miguel Antonio Aon
Since the beginning of this century, the emergence of systems biology, driven by technological, informatic, and theoretical advances, has led to an unprecedented generation of data and information about biological systems at multiple levels...
Ligand Binding Dynamics of Ion Channels and GPCRs Using Single-Molecule Fluorescence [0.03%]
利用单分子荧光研究离子通道和G蛋白偶联受体的配体结合动力学
Susovan Roy Chowdhury,Randall H Goldsmith,Baron Chanda
Susovan Roy Chowdhury
Chemical signaling underlies many biological processes, and membrane receptors such as G protein-coupled receptors and ligand-gated ion channels represent two of the most pharmacologically important protein families. Advances in single-mole...
Mitochondrial Outer Membrane Voltage-Dependent Anion Channels: Unique Structures, Distinct Functions, and Novel Therapeutic Targets [0.03%]
线粒体外膜电压依赖性阴离子通道：独特的结构、不同的功能及潜在的治疗作用
Shashank Ranjan Srivastava,Aadish Rawat,Radhakrishnan Mahalakshmi
Shashank Ranjan Srivastava
Voltage-dependent anion channels (VDACs) of the outer mitochondrial membrane carry out bidirectional flux of metabolites and ions and serve as the first line of communication between the cytosol and mitochondria. They are now recognized as ...
Zhenfeng Liu,Xin You,Mei Li et al.
Zhenfeng Liu et al.
Photosynthesis, the biological process of converting light energy into chemical energy, involves light harvesting, charge separation and electron transport, proton translocation, ATP synthesis, and carbon fixation, among other processes. Ad...
François X P Bourassa,Sooraj Achar,Grégoire Altan-Bonnet et al.
François X P Bourassa et al.
T cells are central to the adaptive immune response, capable of detecting pathogenic antigens while ignoring healthy tissues with remarkable specificity and sensitivity. Quantitatively understanding how T cell receptors discern among antige...
Maria Yampolskaya,Pankaj Mehta
Maria Yampolskaya
Hopfield models, originally developed to study memory retrieval in neural networks, have become versatile tools for modeling diverse biological systems in which function emerges from collective dynamics. In this review, we provide a pedagog...
Nonequilibrium Thermodynamics of Biochemical Networks: Energetics of Cellular Functions [0.03%]
生化网络的非平衡热力学-细胞功能的能量学
Yuhai Tu
Yuhai Tu
I review recent advances in nonequilibrium thermodynamics of biochemical networks, organized around two central questions. First, why is free energy dissipation essential for enabling or enhancing biological function? Second, how do energet...
Nikolai Slavov
Nikolai Slavov
Over the last decade, proteomics analysis of single cells by mass spectrometry transitioned from an uncertain possibility to a set of robust and rapidly advancing technologies supporting the accurate quantification of thousands of proteins....