Cholesterol and Lipid Rafts in the Biogenesis of Amyloid-β Protein and Alzheimer's Disease [0.03%]
胆固醇和脂筏在淀粉样蛋白-β蛋白质生物发生及阿尔兹海默症中的作用
George A Pantelopulos,Conor B Abraham,John E Straub
George A Pantelopulos
Cholesterol has been conjectured to be a modulator of the amyloid cascade, the mechanism that produces the amyloid-β (Aβ) peptides implicated in the onset of Alzheimer's disease. We propose that cholesterol impacts the genesis of Aβ not ...
Bacterial Electrophysiology [0.03%]
细菌的电生理学
Wei-Chang Lo,Ekaterina Krasnopeeva,Teuta Pilizota
Wei-Chang Lo
Bacterial ion fluxes are involved in the generation of energy, transport, and motility. As such, bacterial electrophysiology is fundamentally important for the bacterial life cycle, but it is often neglected and consequently, by and large, ...
Agustín Mangiarotti,Rumiana Dimova
Agustín Mangiarotti
Biomolecular condensates are highly versatile membraneless organelles involved in a plethora of cellular processes. Recent years have witnessed growing evidence of the interaction of these droplets with membrane-bound cellular structures. C...
From Nucleosomes to Compartments: Physicochemical Interactions Underlying Chromatin Organization [0.03%]
从核小体到隔室：染色质组织中物理化学作用力的关系
Shuming Liu,Advait Athreya,Zhuohan Lao et al.
Shuming Liu et al.
Chromatin organization plays a critical role in cellular function by regulating access to genetic information. However, understanding chromatin folding is challenging due to its complex, multiscale nature. Significant progress has been made...
Next-Generation Genetically Encoded Fluorescent Biosensors Illuminate Cell Signaling and Metabolism [0.03%]
下一代基因编码的荧光生物传感器揭示细胞信号和代谢
Michelle S Frei,Sohum Mehta,Jin Zhang
Michelle S Frei
Genetically encoded fluorescent biosensors have revolutionized the study of cell signaling and metabolism, as they allow for live-cell measurements with high spatiotemporal resolution. This success has spurred the development of tailor-made...
Emergent Spatiotemporal Organization in Stochastic Intracellular Transport Dynamics [0.03%]
随机细胞内运输动力学中浮现的时空组织结构
Kunaal Joshi,Harrison M York,Charles S Wright et al.
Kunaal Joshi et al.
The interior of a living cell is an active, fluctuating, and crowded environment, yet it maintains a high level of coherent organization. This dichotomy is readily apparent in the intracellular transport system of the cell. Membrane-bound c...
NMR and Single-Molecule FRET Insights into Fast Protein Motions and Their Relation to Function [0.03%]
对快速蛋白质运动及其与功能关系的NMR和单分子FRET研究
Paul Schanda,Gilad Haran
Paul Schanda
Proteins often undergo large-scale conformational transitions, in which secondary and tertiary structure elements (loops, helices, and domains) change their structures or their positions with respect to each other. Simple considerations sug...
When Force Met Fluorescence: Single-Molecule Manipulation and Visualization of Protein-DNA Interactions [0.03%]
力与荧光相遇：蛋白质DNA相互作用的单分子操控和可视化
Gabriella N L Chua,Shixin Liu
Gabriella N L Chua
Myriad DNA-binding proteins undergo dynamic assembly, translocation, and conformational changes while on DNA or alter the physical configuration of the DNA substrate to control its metabolism. It is now possible to directly observe these ac...
Mitochondrial Dynamics at Different Levels: From Cristae Dynamics to Interorganellar Cross Talk [0.03%]
不同水平的线粒体动态变化：从嵴动力学到器官间的相互作用
Arun Kumar Kondadi,Andreas S Reichert
Arun Kumar Kondadi
Mitochondria are essential organelles performing important cellular functions ranging from bioenergetics and metabolism to apoptotic signaling and immune responses. They are highly dynamic at different structural and functional levels. Mito...
McKenze J Moss,Laura M Chamness,Patricia L Clark
McKenze J Moss
The rate of protein synthesis is slower than many folding reactions and varies depending on the synonymous codons encoding the protein sequence. Synonymous codon substitutions thus have the potential to regulate cotranslational protein fold...