Biophysics of knotting [0.03%]
结的生物物理
Dario Meluzzi,Douglas E Smith,Gaurav Arya
Dario Meluzzi
Knots appear in a wide variety of biophysical systems, ranging from biopolymers, such as DNA and proteins, to macroscopic objects, such as umbilical cords and catheters. Although significant advancements have been made in the mathematical t...
Steven O Smith
Steven O Smith
Rhodopsin is a specialized G protein-coupled receptor (GPCR) found in vertebrate rod cells. Absorption of light by its 11-cis retinal chromophore leads to rapid photochemical isomerization and receptor activation. Recent results from protei...
Kim Sneppen,Sandeep Krishna,Szabolcs Semsey
Kim Sneppen
The function of living cells is controlled by complex regulatory networks that are built of a wide diversity of interacting molecular components. The sheer size and intricacy of molecular networks of even the simplest organisms are obstacle...
Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity [0.03%]
真核生物趋化性：信号通路网络控制运动、定向感应和极性形成
Kristen F Swaney,Chuan-Hsiang Huang,Peter N Devreotes
Kristen F Swaney
Chemotaxis, the directed migration of cells in chemical gradients, is a vital process in normal physiology and in the pathogenesis of many diseases. Chemotactic cells display motility, directional sensing, and polarity. Motility refers to t...
H Lee Sweeney,Anne Houdusse
H Lee Sweeney
The general structural features of the motor region of myosin superfamily members are now well established, as is a subset of the structural and kinetic transitions of the actin-myosin catalytic cycle. Not yet visualized are the structural ...
Stephanie Szobota,Ehud Y Isacoff
Stephanie Szobota
Advances in optics, genetics, and chemistry have enabled the investigation of brain function at all levels, from intracellular signals to single synapses, whole cells, circuits, and behavior. Until recent years, these research tools have be...
D Thirumalai,Edward P O&#x;Brien,Greg Morrison et al.
D Thirumalai et al.
Understanding how monomeric proteins fold under in vitro conditions is crucial to describing their functions in the cellular context. Significant advances in theory and experiments have resulted in a conceptual framework for describing the ...
Sarah A Woodson
Sarah A Woodson
Large noncoding RNAs fold into their biologically functional structures via compact yet disordered intermediates, which couple the stable secondary structure of the RNA with the emerging tertiary fold. The specificity of the collapse transi...
Wei Yang
Wei Yang
How do molecular motors convert chemical energy to mechanical work? Helicases and nucleic acids offer simple motor systems for extensive biochemical and biophysical analyses. Atomic resolution structures of UvrD-like helicases complexed wit...
Bacterial microcompartment organelles: protein shell structure and evolution [0.03%]
细菌微隔室器官：蛋白质壳结构与进化
Todd O Yeates,Christopher S Crowley,Shiho Tanaka
Todd O Yeates
Some bacteria contain organelles or microcompartments consisting of a large virion-like protein shell encapsulating sequentially acting enzymes. These organized microcompartments serve to enhance or protect key metabolic pathways inside the...