Mucosal BCG vaccination reprograms lung interstitial macrophages and enhances antimicrobial defense in mice [0.03%]
黏膜卡介苗接种可重塑小鼠肺间质巨噬细胞功能并增强其抗微生物防御能力
Aaron James Forde,Mara Esposito,Emanuela Kerschbamer et al.
Aaron James Forde et al.
Bacille Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB) but provides inconsistent protection against disease. Alveolar macrophages (AM) are widely considered the primary myeloid mediators of BCG-induced lung im...
Beyond antibodies: Emerging roles of B cells in gastrointestinal inflammation and disease [0.03%]
超越抗体：B细胞在胃肠道炎症和疾病中的新兴作用
Marina Costa Fujishima,Jing Ouyang,Thomas T Murooka et al.
Marina Costa Fujishima et al.
B cells play a crucial role in maintaining immune homeostasis at mucosal surfaces, including those of the gastrointestinal (GI) tract. Perturbed humoral immunity and antibody-mediated functions of B cells are well described in patients with...
Single-cell RNA sequencing reveals intrinsic and microbiota-associated sex differences in murine lung [0.03%]
单细胞RNA测序揭示了小鼠肺部内在和与微生物群相关的性别差异
Alexandra Melton,Krista Ferrari,Joseph P Hoffmann et al.
Alexandra Melton et al.
Sex-based differences in respiratory disease outcomes are well recognized. However, the underlying immunological mechanisms driving this dimorphism remain incompletely understood. While sex hormones influence immune cell development and fun...
Gammaherpesvirus infection impairs lung fibrosis resolution through PD-L1+ fibroblasts and PD-1+ CD8+ T cell interaction [0.03%]
γ疱疹病毒感染通过PD-L1+成纤维细胞和PD-1+CD8+T细胞相互作用损害肺纤维化恢复
Laura Kempen,Domien Vanneste,Justine Javaux et al.
Laura Kempen et al.
Pulmonary fibrosis is a complex disease with poorly understood, multifactorial triggers. Gammaherpesviruses (γHVs), including Epstein-Barr virus in humans and Murid herpesvirus 4 (MuHV-4) in mice, have been linked to pulmonary fibrosis exa...
Dysregulated MUC5B and MUC5AC impair epithelial barrier function and alter granulocyte frequency and activation in the lung and distal sites [0.03%]
失调的MUC5B和MUC5AC会损害上皮屏障功能并改变肺部和远端位点的粒细胞频率和活化状态
Neeraj Patil,Jonas Ambjörnsson,Sofia Kallin et al.
Neeraj Patil et al.
Background: Mucus obstructs the airways in respiratory diseases where MUC5B is the major gel-forming mucin in COPD and MUC5AC-rich mucus dominates in asthma. Mucin production changes in response to inflammatory signals, b...
Accumulation of mucosal and lymphoid hypo-functional granzyme K producing CD8+ effector memory T cells in idiopathic pulmonary fibrosis [0.03%]
特发性肺纤维化患者黏膜和淋巴组织中低功能颗粒酶K产生CD8+效应记忆T细胞的积累
Jetina Okereke,Andrew Craig,Michelle Rojas et al.
Jetina Okereke et al.
Idiopathic pulmonary fibrosis is a progressive lung disease characterized by the rapid scarring of the lung parenchyma resulting in impaired gas exchange and early mortality. Current treatment options are limited; lung transplantation remai...
Gone but not forgotten: lung infection history shapes future respiratory immunity [0.03%]
往事并不如烟：肺部感染史塑造未来呼吸道免疫系统
Alicia Dirlam,Chrysante S Iliakis,Andreas Wack
Alicia Dirlam
After respiratory infection, the lung does not simply return to the prior baseline but adopts a new distinct post-infection steady state involving durable imprints that can shape tissue responses to subsequent challenges. This review introd...
Early postnatal eosinophil expansion associates with gut microbial-metabolic features and type 2 immunity in preterm infants [0.03%]
早产婴儿早期外周血嗜酸性粒细胞增多与肠道微生物-代谢特征及2型免疫反应相关性研究
Huiyu Chen,Yihuang Huang,Luyang Hong et al.
Huiyu Chen et al.
Background: Early postnatal gut colonization, microbial metabolite production, and immune maturation proceed in parallel. Although disruption has been linked to later allergic disease, cellular immune patterns remain insu...
Gut segmented filamentous Bacteria impedes growth of B16F10 subcutaneous tumors via modulating T cell function [0.03%]
肠段丝状细菌通过调节T细胞功能抑制B16F10皮下肿瘤生长
Hirohito Abo,Seong-Eun G Kim,Vu L Ngo et al.
Hirohito Abo et al.
Intestinal microbiota composition influences innate and adaptive immunity, both within and beyond the intestine. A prominent example of the latter is segmented filamentous bacteria (SFB), whose gut colonization reprograms alveolar macrophag...
Mucosal immunity as a vaccine-induced correlate of protection against influenza [0.03%]
黏膜免疫作为流感疫苗保护作用的效应指标
A R Dvorscek,A S Kushnir,O Dibben et al.
A R Dvorscek et al.
Licensure of influenza vaccines relies on serum hemagglutination inhibition (HAI) titers, a correlate of protection (CoP) that was developed more than 50 years ago and which is only poorly predictive of protection. This is especially true o...