Systemic IgE promotes allergic rhinitis by licensing Th2-to-Tfh conversion and local IgE production [0.03%]
系统性IgE通过促进Th2向Tfh转化及局部IgE生成来促进变应性鼻炎发生发展
Takuya Nakai,Saya Tezuka,Takumi Adachi et al.
Takuya Nakai et al.
Although systemic allergen-specific IgE is an essential biomarker for allergic rhinitis (AR), its mechanistic contribution to symptom development remains unclear. Here, using mouse models, we investigated how systemic antigen-specific IgE i...
SENP1 facilitates the adaptation of colonic non-lymphoid tissue Treg cells and restrains intestinal inflammation [0.03%]
SENP1促进结肠非淋巴组织Treg细胞的适应并抑制肠道炎症
Yanyun Hao,Hongzhi Liu,Qiuli Liang et al.
Yanyun Hao et al.
Colonic immune homeostasis is critically maintained by regulatory T (Treg) cells. Here, we identify SUMO-specific peptidase 1 (SENP1) as an important regulator of colonic Treg function and intestinal immune homeostasis. Treg-specific Senp1 ...
Human enteric defensin 5 protects intestinal barrier integrity via cell state-dependent P2Y11-FAK-Rac1 signaling [0.03%]
人肠防御素5通过细胞状态依赖性的P2Y11-FAK-Rac1信号保护肠道屏障的完整性
Mengyao Guo,Yaqian Zhang,Yaxin Liu et al.
Mengyao Guo et al.
Human enteric α-defensin 5 (HD5) is an antimicrobial peptide and a key effector of intestinal mucosal innate immunity. Paradoxically, HD5 has also been shown to enhance Shigella infection by inducing filopodia-like extensions via activatio...
Candidalysin promotes fungal-specific Th17 CD4 T cell differentiation and protective systemic immunogenicity [0.03%]
candidalysin促进真菌特异性Th17 CD4 T细胞分化和保护性全身免疫原性
Ngan N M Nguyen,Alexander E Brady,David B Haslam et al.
Ngan N M Nguyen et al.
Commensal microbes can cause invasive infection but can also stimulate protective immune responses as exemplified by the gut pathobiont Candida albicans. This species primes systemic Th17 immunogenicity which protects against disseminated i...
James I King,Isabelle C Arnold
James I King
Eosinophils have traditionally been viewed as terminally differentiated type 2 effector cells involved in anti-helminth immunity and allergic inflammation. Recent advances in single-cell transcriptomics have refined this view, revealing sub...
CTL lymph node entrapment drives lymphopenia in severe influenza infection [0.03%]
严重的流感感染中CTL淋巴结陷获驱动淋巴细胞减少现象
Aira F Cabug,Nichollas E Scott,Heran Zhang et al.
Aira F Cabug et al.
Influenza virus infection can result in outcomes ranging from moderate, self-limiting illness to severe, life-threatening disease. Although severe cases are frequently associated with CD8+ T cell lymphopenia, the underlying mechanisms drivi...
Cannabidiol prevents mucosal HIV-1 transmission by targeting Langerhans cells, dendritic cells, macrophages and T-cells [0.03%]
大麻二酚通过靶向朗格汉斯细胞、树突状细胞、巨噬细胞和T细胞来预防粘膜HIV-1感染
Caio César Barbosa Bomfim,Hugo Génin,Jammy Mariotton et al.
Caio César Barbosa Bomfim et al.
HIV-1 transmission depends on the structure and immune cell composition of mucosal epithelia. Transmission mechanisms involve direct infection of CD4+ T-cells or macrophages, and indirect viral transfer to CD4+ T-cells from Langerhans cells...
Guo Yin,Yasmina Chouik,Yawen Hao et al.
Guo Yin et al.
Mucosal immunology traditionally applies to mucosal surfaces encountering microorganisms and environmental antigens, while the biliary tree is mostly regarded as a duct connecting the liver to the intestines. On the one hand, the biliary ep...
CD160-competent ILC2 are crucial for the ejection of intestinal helminths by the innate immune system [0.03%]
依赖先天淋巴细胞CD160介导的天然免疫系统驱虫反应
Lennart Heepmann,Wiebke Hartmann,Lara Linnemann et al.
Lennart Heepmann et al.
1.6 billion people are currently infected with parasitic worms. Group 2 innate lymphoid cells (ILC2) play a central role in promoting the protective type 2 immunity against these parasites. Here we show that a subpopulation of intestinal IL...
Eomes fate-labeling reveals a subset of Eomeslo NK cells that exhibits an ILC1-like phenotype [0.03%]
Eomes命运标记揭示了一组表现出ILC1样表型的Eomes低表达NK细胞
Vladislava Stokic-Trtica,Johannes Steffen,Xuemei Gao et al.
Vladislava Stokic-Trtica et al.
Innate lymphoid cells (ILCs) are distinct lineages defined by lineage-specifying transcription factors that drive their differentiation and effector programs. Despite being stable lineages, ILC plasticity has been reported. Plasticity is ch...