The nematode C. elegans as an animal model to explore toxicology in vivo: solid and axenic growth culture conditions and compound exposure parameters [0.03%]
利用动物模型C.elegans探究活体毒理学：固体和无菌生长培养条件及化合物接触参数
Richard Nass,Iqbal Hamza
Richard Nass
Significant limitations in vertebrate animal model systems include the time involved, the expense, the fact that in vitro results may not reflect live animal pathology, difficulties in transporting the toxin past the blood brain barrier, an...
Stephanie Padilla,John Cowden,David E Hinton et al.
Stephanie Padilla et al.
Small aquarium fishes are increasingly used as animal models, and one of these, the Japanese Medaka (Oryzias latipes), is frequently utilized for toxicity testing. While these vertebrates have many similarities with their terrestrial counte...
Laura Gribaldo
Laura Gribaldo
In vitro toxicology generally refers to the study of toxicological phenomena in non-whole-animal models. This broader connotation includes studies utilizing isolated organs, tissue slices, explants cultures, and isolated primary cells, as w...
Zuzana Drobna,Miroslav Styblo,David J Thomas
Zuzana Drobna
Inorganic arsenic is extensively metabolized to produce mono-, di-, and trimethylated products. The formation of these metabolites produces a variety of intermediates that differ from inorganic arsenic in terms of patterns of distribution a...
Dejan Milatovic,Thomas J Montine,Snjezana Zaja-Milatovic et al.
Dejan Milatovic et al.
The study of dendritic length and spine density has become a standard in the analysis of neuronal abnormalities since a considerable number of neurological diseases have their foundation in alterations in these structures. One of the best w...
Araceli Hernandez-Zavala,Zuzana Drobna,Miroslav Styblo et al.
Araceli Hernandez-Zavala et al.
Quantitation of iAs and its methylated metabolites in biological samples provides dosimetric information needed to understand dose-response relations. Here, methods are described for separation of inorganic and mono-, di-, and trimethylated...
Measurement of isoprostanes as markers of oxidative stress in neuronal tissue [0.03%]
异前列腺素作为神经组织中氧化应激标志物的测定方法
Dejan Milatovic,Michael Aschner
Dejan Milatovic
Oxidative stress is implicated in the pathogenesis of a variety of human diseases, including neurodegenerative disease, atherosclerosis and cancer, as well as progressive and even normal aging processes. Increased generation of free radical...
Martha H Stipanuk,John E Dominy Jr,Iori Ueki et al.
Martha H Stipanuk et al.
Cysteine dioxygenase is an iron (Fe(2+))-dependent thiol dioxygenase that uses molecular oxygen to oxidize the sulfhydryl group of cysteine to generate 3-sulfinoalanine (commonly called cysteinesulfinic acid). Cysteine dioxygenase activity ...