G Sanders,C Ware,W Ladiges
G Sanders
This unit contains an extensive tabular listing of transgenic and gene-targeted mice useful in toxicological studies. Each listing contains a brief description of the phenotype, relevant references, and where applicable, commercial sources.
Radioactivity [0.03%]
放射性
This appendix provides selected properties of radioisotopes commonly used in the molecular biology laboratory. © 2008 by John Wiley & Sons, Inc.
Koji Takeuchi,Hiroshi Satoh
Koji Takeuchi
Many animal models have been devised for investigating the pathogenesis of intestinal lesions and for screening drugs for the treatment of intestinal ulcers in humans. Recently, particular attention has been focused on NSAID-induced intesti...
Stanislaw J Konturek,Wladysław Bielanski,Peter C Konturek et al.
Stanislaw J Konturek et al.
The protocols described in this unit are designed to present the major endogenous gastric mediators involved in the control of gastric acid secretion, namely gastrin and histamine, and in the regulation of gastric motility, which include mo...
Maristella Adami,Gabriella Coruzzi
Maristella Adami
The protocols described in this unit are designed to assess the effects of substances on gastric acid secretion by the rat stomach, with the animal under general anesthesia. Both stimulatory and inhibitory effects of compounds can be evalua...
Viera Nosál&#x;ová,Ruzena Sotníková
Viera Nosál&#x;ová
This protocol describes a model convenient for acute experiments in anesthetized rats, performed by selective occlusion of the superior mesenteric artery. Such a model provides a means for assessing the role played by various pathophysiolog...
Alessandro Menozzi,Maria Cristina Ossiprandi
Alessandro Menozzi
The disruption of intestinal barrier leads to the penetration of noxious luminal compounds into the gut wall, causing further damage. This unit describes the assessment of enteric bacteria translocation into the intestinal wall of rats, an ...
Giuseppina Morini,Daniela Grandi
Giuseppina Morini
The maintenance of gastric mucosal integrity is ensured by a dynamic balance between protective and noxious factors. The gastric mucosa has multiple protective mechanisms that allow the mucosa to withstand frequent exposure to potentially d...
Gabriella Coruzzi
Gabriella Coruzzi
The gastrointestinal (GI) tract has the unique feature of having a huge area for exposure to potentially harmful agents, including concentrated acid, food, chemicals, and pathogens. Research over the past decades has identified some of the ...
Dominique Parent-Massin,Yann Sibiril
Dominique Parent-Massin
In this unit, protocols to culture human platelet progenitors (Colony Forming Unit-Megakaryocyte; CFU-M) with or without toxicants are described. Platelet progenitors are obtained from human umbilical cord blood. After separation of mononuc...