Jesica McCue,Brian Freed
Jesica McCue
Adequate immune function requires the complex interaction between cells via a series of biochemical and molecular events, culminating in altered gene expression. Initiation of transcription by sequence-specific DNA-binding proteins known as...
Dario C Ramirez,Ronald P Mason
Dario C Ramirez
Protein-centered radicals are involved in biological oxidative damage induced by drugs, environmental hazards, and cellular reactive oxygen species. Presently, the technique most widely used to study protein-centered radicals is electron sp...
Quantification of F2-isoprostanes by gas chromatography/mass spectrometry as a measure of oxidant stress [0.03%]
气相色谱/质谱法测定F2-异前列腺素作为氧化应激的指标
Erik S Musiek,Jason D Morrow
Erik S Musiek
Oxidative stress has been implicated in a wide variety of disease processes. One method to quantify oxidative injury is to measure lipid peroxidation. Most methods to do this are fraught with problems particularly when utilized to assess ox...
Erik S Musiek,Jason D Morrow
Erik S Musiek
The isoprostanes are a unique series of prostaglandin-like compounds formed in vivo via a non-enzymatic mechanism involving the free radical-initiated peroxidation of arachidonic acid. This unit summarizes selected aspects regarding current...
Francesca Capone,Luca Tommaso Bonsignore,Francesca Cirulli
Francesca Capone
The aim of this unit is to provide a set of fundamental protocols to assess maternal behavior in rats and mice. Parental behavior in rodents is characterized by a rather complex set of behavioral items, which are described in great detail. ...
Flavia Chiarotti
Flavia Chiarotti
The statistical analysis of behavioral data follows the collection and checking of the data, and is aimed at assessing the effect of treatments on the observed behaviors. In this unit, different behavioral tests and the response variables c...
Igor Branchi,Giorgio Bignami,Enrico Alleva
Igor Branchi
The discipline of behavioral teratology is based on the study of behavior as a powerful tool to identify and disentangle noxious effects of compounds known or suspected to be potentially neurotoxic early during development. Indeed, because ...
M Livia Terranova,Giovanni Laviola
M Livia Terranova
This unit provides a description of methods that have proven useful in characterizing amicable and playful interactions of developing mice. Such a procedure can be used to evaluate the effects of perinatal and/or ongoing treatments on the s...
Morphological measurement of neurotoxic injury in the peripheral nervous system: preparation of material for light and transmission electron microscopic evaluation [0.03%]
周围神经系统的神经毒性损伤的形态计量学测定：光镜和透射电镜检测材料的制备
S K Hancock,J Hinckley,M Ehrich et al.
S K Hancock et al.
An important method of assessing experimental neurotoxic injury is the pathologic examination of the nervous system. Methods for fixation, sampling, and preparation of peripheral nervous system tissues for critical pathological neurotoxicol...
Hari Shanker Sharma
Hari Shanker Sharma
With the increase in global warming, the problems of hyperthermia have recently attracted world-wide medical attention. Deaths due to heat-related illnesses that have occurred in many human populations in recent years are now recognized as ...