Diagnostic performance of artificial intelligence models trained on scattered single-cell images is not preserved for hyperchromatic crowded cell groups in cervical cytology [0.03%]
人工智能模型对宫颈细胞学中弥漫性单个细胞图像的诊断性能不适用于高染色体拥挤细胞群
Shinichi Tanaka,Yudai Yamamoto,Konatsu Yokota et al.
Shinichi Tanaka et al.
Background: Deep learning has shown promising performance in cervical cytology; however, many studies have relied on presegmented single-cell images rather than the more complex morphologic patterns encountered in routine...
Feasibility of routine clinical liquid-based cytology for lung cancer compact panel testing [0.03%]
基于临床液体标本的肺癌(compact panel)检测可行性研究
Yoshiki Shinomiya,Kanako C Hatanaka,Asami Okumura et al.
Yoshiki Shinomiya et al.
Background: The Lung Cancer Compact Panel (cPANEL) is a recently approved highly sensitive multiplex gene panel in Japan that supports both DNA- and RNA-based next-generation sequencing. Although cytological specimens are...
Screening efficiency over experience: Rapid target detection in low-power field as a modifiable cognitive biomarker for diagnostic accuracy in digital cytology [0.03%]
高效的筛查：低功率视野下快速靶标检测作为数字细胞学诊断准确性可修改的认知生物标志物
Naoya Abe,Yukari Nishimura,Kazuya Yamashita et al.
Naoya Abe et al.
Background: Traditionally, cytology expertise has been equated with professional experience. However, the transition to whole-slide imaging and artificial intelligence (AI) necessitates a shift from exhaustive screening t...
Much promise, scant evidence for multicancer early detection tests: In this first of a two-part series on new blood-based cancer tests, direct-to-consumer pitches for multicancer detection have far outpaced evidence of real-world benefits [0.03%]
多癌种早筛泛滥：营销证据远超科学证据
Bryn Nelson,William Faquin
Bryn Nelson
Standardizing the unstandardized: The international system reaches the cerebrospinal fluid [0.03%]
无标准化到有标准化：国际体系与脑脊液标准的建立
Ashish Chandra
Ashish Chandra
Two new studies now make the most substantial case yet that the framework of the International System for Reporting Serous Fluid Cytopathology can be carried across the biologic boundary to include cerebrospinal fluid, and current work on t...
Implementation and impact of primary HPV testing in cervical cancer screening: Historical perspectives and institutional experience at a large academic medical center [0.03%]
宫颈癌筛查中HPV初筛的实施及影响：历史观点与大型学术医学中心的机构经验
Rebecca A Yoda,Eric C Huang
Rebecca A Yoda
Recognition of high-risk human papillomavirus (HPV) as the etiologic agent in nearly all cervical cancers has fundamentally reshaped screening strategies, driving the development and adoption of highly sensitive molecular HPV assays. Over t...
Keratin 17 immunocytochemistry in urine cytology for urothelial carcinoma detection: Diagnostic performance and interobserver agreement in a prospective real-world cohort [0.03%]
尿液细胞学中免疫细胞化学法检测角蛋白17用于诊断泌尿系统移行细胞癌的诊断性能及观察者间的协议研究：一项前瞻性真实世界队列研究
Gregor Barth,Stefan Koch,Thorsten H Ecke
Gregor Barth
Background: Urine cytology is recommended for noninvasive detection of urothelial carcinoma (UC) but shows limited sensitivity, particularly in low-grade disease. Keratin 17 (K17) has emerged as a promising immunocytochem...
Molecular profiling of breast cancer pleural effusions using cytology specimens: Impact of sample source and cytological features on next-generation sequencing performance [0.03%]
乳腺癌胸腔积液的分子分型检测——细胞学标本来源及细胞学特征对高通量测序性能的影响分析
Harpreet Virk,Claire Michael,Keri Ann Pfeil et al.
Harpreet Virk et al.
Background: Malignant effusions in breast cancer are a minimally invasive source for molecular profiling. Effusion-derived cytology specimens, cell blocks (CB) and post-ThinPrep PreservCyt (PTPC) supernatant, are reliable...
Accurate focal-plane selection is crucial for artificial intelligence assessment of three-dimensional urine cytology specimens for bladder cancer screening and surveillance [0.03%]
精确的焦平面选择对于人工智慧评估三维尿细胞学样本以筛查和监测膀胱癌至关重要
Yoseph Sayegh,Brody McNutt,Minh-Khang Le et al.
Yoseph Sayegh et al.
Background: Bladder cancer is a common and highly recurrent malignancy requiring lifelong surveillance. Urine cytology serves as a noninvasive triage tool to guide cystoscopy but is limited by variable sensitivity and man...