Cryptococcus exploits delayed microglial activation, and microglial osteopontin/Spp1 impairs peripheral host control [0.03%]
隐球菌利用微胶质细胞激活的延迟，并且微胶质细胞osteopontin/Spp1损害外周宿主控制
Estefany Y Reyes,Jae Yong,Devon T DiPalma et al.
Estefany Y Reyes et al.
Cryptococcus, a neurotropic fungus classified as a critical-priority pathogen by the World Health Organization (WHO), causes cryptococcal meningoencephalitis (CM), the second leading cause of death in HIV/AIDS patients. Despite its clinical...
Lantibiotic-producing bacteria impact microbiome resilience and colonization resistance [0.03%]
产 lanthionine抗生素的细菌影响微生物组的弹性和定植抗性
Cody G Cole,Zhenrun J Zhang,Shravan R Dommaraju et al.
Cody G Cole et al.
A subset of commensal bacterial strains secretes bacteriocins, such as lantibiotics, to inhibit or kill neighboring bacteria, thereby protecting their niche in the gut. The antimicrobial spectrum of lantibiotics includes pathogens, offering...
Diet modulates Vibrio cholerae colonization and competitive outcomes with the gut microbiota [0.03%]
饮食调节霍乱弧菌的定植及其与肠道微生物的竞争结果
Rui Liu,Yue Zhang,Siyi Ge et al.
Rui Liu et al.
The amount or type of dietary macronutrients dramatically changes the microbiota and physicochemical environment of the gut. Because the microbiota plays key roles in pathogen susceptibility, macronutrients could impact infection outcomes. ...
Kine Eide Kvitne,Celeste Allaband,Jennifer C Onuora et al.
Kine Eide Kvitne et al.
Early life is a critical period for immune and metabolic development, but these patterns remain underexplored in populations from low- and middle-income countries. Here, we profile the microbiome and metabolome of 55 Bangladeshi mother-infa...
Exploring functional insights into the human gut microbiome via the structural proteome [0.03%]
通过结构蛋白质组探索人体肠道微生物组的功能见解
Hongbin Liu,Juntao Shen,Zhiwei Zhang et al.
Hongbin Liu et al.
The human gut microbiome contains numerous proteins whose functions remain elusive yet are pivotal to host health. Sequence-based methods often falter when attempting to infer functions within this microbial proteome due to evolutionary div...
Erin E Doherty,Jason Nomburg,Benjamin A Adler et al.
Erin E Doherty et al.
Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase (PDE)-mediated oligonucleotide cleavage...
The microbial metabolite imidazole propionate modulates hypothalamic activity and stress-induced behaviors [0.03%]
微生物代谢产物咪唑丙酸可调节下丘脑活动和应激诱导的行为反应
Gulistan Agirman,Michael N B Quicho,Kaden K Connelley et al.
Gulistan Agirman et al.
Metabolic disorders are associated with gut microbiome imbalance, which can have additional physiological effects. The microbial metabolite imidazole propionate (ImP) is elevated in type 2 diabetes and has been linked to exacerbated metabol...
Hologenomic insights into the molecular adaptation of deep-sea coral Bathypathes pseudoalternata [0.03%]
深海珊瑚Bathypathes pseudoalternata的全基因组适应性分子机制研究
ZhanFei Wei,Yi Lan,LiHui Meng et al.
ZhanFei Wei et al.
Deep-sea coral ecosystems support biodiversity and nutrient cycling through interactions with symbionts. However, their molecular mechanisms remain unexplored. Here, hologenomic analyses of Bathypathes pseudoalternata are applied to uncover...
Keystone Pseudomonas species in the wheat phyllosphere microbiome mitigate Fusarium head blight by altering host pH [0.03%]
小麦叶球微生物组中的关键假单胞菌物种通过改变宿主pH值来缓解头枯萎病
Yujiao Xu,Zhiyuan Wang,Jinmei Wu et al.
Yujiao Xu et al.
Phyllosphere microbiota play crucial roles in supporting host performance. However, the dynamic changes of phyllosphere-associated microbiome during pathogen infections and their impacts on plant health remain unknown. Here, we found phyllo...
Chin-Hsien Lin,Wei-Li Wu
Chin-Hsien Lin
Motor complications in Parkinson's disease (PD) are exacerbated by the pulsatile delivery of levodopa (L-DOPA). In this issue of Cell Host & Microbe, Padhi et al. engineer a microbiota-based therapeutic for sustained, non-fluctuating L-DOPA...