A DNA recognition-mimicry switch governs induction in arbitrium phages [0.03%]
仲裁素噬菌体诱导的开关机制基于对DNA的识别与模仿
Cora Chmielowska,Sara Zamora-Caballero,Javier Mancheño-Bonillo et al.
Cora Chmielowska et al.
Temperate phages integrate multiple information sources to regulate lysis-lysogeny transitions. SPbeta-like phages use arbitrium signaling and DNA damage to control repressor activity during lytic induction, but how the repressor functions ...
Evolution of root nodule symbiosis via paleopolyploidy and modular pathway rewiring [0.03%]
古老的多倍体现在如何通过模块化途径重新布线进化出根瘤共生现象
Hui Liu,Ling Hou,Liying Lan et al.
Hui Liu et al.
The evolution of root nodule symbiosis (RNS), a key innovation for plant nitrogen acquisition, has long been studied but lacks a mechanistic, gene-level evolutionary framework. Here, we reconstruct the gene regulatory network underlying RNS...
Predation by soil protists shifts bacterial metabolism from competitive to cooperative interactions [0.03%]
土壤原生动物的捕食作用使细菌代谢从竞争互作转向合作互作
Chen Liu,Shuo Sun,Xiangyu Ren et al.
Chen Liu et al.
Many soil protists are bacterivores, yet how protist predation reshapes bacterial metabolic interactions and functions remains poorly understood. Here, we combine global soil samples with microbial metabolic simulations, along with soil mic...
Temporal transcriptional rhythms govern coral-symbiont function and microbiome dynamics [0.03%]
时间转录节律控制珊瑚-共生生物功能和微生物群动态
Bradley Allen Weiler,Nicholas Kron,Anthony Mario Bonacolta et al.
Bradley Allen Weiler et al.
Diel rhythms align physiological processes with light/dark cycles, driving predictable oscillations in gene expression and protein activity through tightly controlled transcriptional-translational feedback loops. This study presents in situ...
Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections [0.03%]
粪肠球菌衍生的乳酸通过抑制巨噬细胞活化来促进慢性及多微生物感染
Ronni A G da Silva,Brenda Yin Qi Tien,Patrick Hsien Neng Kao et al.
Ronni A G da Silva et al.
Macrophage activation is essential for innate immunity and antimicrobial defense. We show that Enterococcus faecalis suppresses macrophage activation through lactic-acid-mediated acidification of the extracellular environment, enabling path...
Engineered probiotics recruit CAR macrophages and establish immune memory to eradicate heterogeneous glioblastoma in mice [0.03%]
工程益生菌招募CAR巨噬细胞并在小鼠中建立免疫记忆以根除异质性胶质母细胞瘤
Yulin Zhang,Jianyu Shen,Yu Xu et al.
Yulin Zhang et al.
Glioblastoma (GBM) remains a highly lethal form of cancer due to its molecular heterogeneity and the immunosuppressive microenvironment surrounding the tumor. Here, we report a modular immunotherapy platform characterized by its flexibility...
Raminder Singh,Manuela Raffatellu
Raminder Singh
The gut mucosal immune system orchestrates diverse defense mechanisms against fungal pathogens. In this issue of Cell Host & Microbe, Bao and Yang et al.1 demonstrate that intestinal epithelial cells secrete an anti-zincophore protein, METT...
Lior Lobel
Lior Lobel
In this issue of Cell Host & Microbe, Qiao et al. show that Bacteroides asparaginase reshapes anti-tumor immunity. When bacteria deplete asparagine, CD8⁺ T cells lose stemness and effector capacity, promoting tumor progression and weakenin...
Christa I DeVette,Marisol Castillo-Castrejon,Jacob E Friedman
Christa I DeVette
Maternal immune tolerance of the fetus is critical to a successful pregnancy. In this month's issue of Cell, Brown et al. showed that the maternal microbiota, specifically tryptophan derivatives produced by commensal bacteria, promote mater...
Ashwin Balagopal,Andrea L Cox
Ashwin Balagopal
Chronic hepatitis B virus (HBV) affects ∼250 million people worldwide. Functional cure is difficult to achieve with existing medications. In this issue, Fernandes et al. developed a double-humanized chronic HBV murine model to test the cap...