A modular alliance: Probiotics and macrophages converge on glioblastoma [0.03%]
模块化联盟：益生菌和巨噬细胞在胶质母细胞瘤中的汇合
Jiarui Zhao,Jian Chen
Jiarui Zhao
Glioblastoma's antigenic heterogeneity and immunosuppressive microenvironment limit therapeutic efficacy. In this issue, Zhang et al. present a multimodal platform where engineered probiotics "paint" diverse tumor cells with a common tag, e...
Zahavah Rojer,Tory A Hendry
Zahavah Rojer
In this issue of Cell Host & Microbe, Hussain et al.1 demonstrate surprising microbiome resilience in oak trees under abiotic and biotic stress. In contrast to work on herbaceous plants or saplings, it was found that mature oak trees growin...
Lu Ma,Longfei Shu
Lu Ma
In the current issue of Cell Host & Microbe, Liu et al. establish a scalable framework and find that protist predation drives bacterial metabolic cooperation. This study offers insights for investigating similar cross-kingdom interactions i...
Cheong Xin Chan
Cheong Xin Chan
In this issue of Cell Host & Microbe, Weiler et al. reveal how a coral, its algal symbiont, and associated microbes coordinate gene activity across day-night cycles in their natural environment. The study establishes a baseline of how coral...
Outsmarting the wicked smart: Using chemistry to overcome bacterial anti-viral systems [0.03%]
用化学方法克服细菌抗病毒系统以智取胜
Antonio Tinoco
Antonio Tinoco
Bacteriophage therapy has regained popularity in treating antibiotic-resistant bacterial infections. However, bacteria encode clever ways to evade lytic cell death inflicted by phages. In this issue, Zang and coworkers report a small molecu...
Meta-analysis of the uncultured gut microbiome across 11,115 global metagenomes reveals a candidate signature of health [0.03%]
基于全球11,115个元基因组的未培养肠道微生物组的荟萃分析揭示了一个潜在的健康标志物
Ana C da Silva,Jacob Lapkin,Qi Yin et al.
Ana C da Silva et al.
The human gut microbiome is important for host health, yet over 60% of gut species remain uncultured and inaccessible to experimental manipulation. Here, we analyze 11,115 human gut metagenomes from 39 countries, 13 noncommunicable diseases...
Gut DNA virome enterotype dictates inflammation heterogeneity through tuning the phage-bacteria-sphingosine-intestine axis in Crohn's disease [0.03%]
肠道DNA病毒型通过调节克罗恩病中噬菌体-细菌-鞘氨醇-肠轴来决定炎症异质性
Weijie Wen,Runping Su,Yunyun Liu et al.
Weijie Wen et al.
The human gut harbors a diverse virome, believed to play a crucial role in maintaining intestinal homeostasis. However, the magnitude of heterogeneity of the gut mucosal virome, and how it differentially regulates host inflammation phenotyp...
HMGB1 functions as a critical mediator of host defense at the gut mucosal barrier [0.03%]
HMGB1作为肠道黏膜屏障宿主防御的关键调节因子的功能作用
Anne-Marie C Overstreet,McKenzie Burge,Brady Anderson et al.
Anne-Marie C Overstreet et al.
Host cells and bacteria constantly communicate across the gut mucosal barrier, yet the molecular details of these interactions remain largely unknown. Here, we report a molecular feedback loop between high mobility group box 1 (HMGB1) and b...
Zhiyu Zang,Olivia K Duncan,Dziugas Sabonis et al.
Zhiyu Zang et al.
The rise of antibiotic resistance motivates a revived interest in phage therapy. However, bacteria possess dozens of anti-phage immune systems that confer resistance to therapeutic phages. Chemical inhibitors of these anti-phage immune syst...
A widespread extended arbitrium system controls lysis/lysogeny through antirepression [0.03%]
一个普遍存在的延伸决策系统通过抗阻抑控制裂解/溶源转换
Stav Kabel,Shira Omer Bendori,Tom Borenstein et al.
Stav Kabel et al.
Many temperate Bacillus phages use the arbitrium peptide-based signaling system to regulate lysis-lysogeny decisions. In this system, the secreted AimP peptide inhibits the AimR receptor to promote lysogeny. However, the downstream mechanis...