Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis [0.03%]
食物过敏原的微生物代谢决定IgE介导的过敏反应的严重程度
Elisa Sánchez-Martínez,Liam E Rondeau,Manuel Garrido-Romero et al.
Elisa Sánchez-Martínez et al.
Anaphylaxis is an acute, potentially life-threatening reaction, often triggered by foods and largely mediated by immunoglobulin (Ig)E. The human microbiota is known to influence oral tolerance, but the microbial mechanisms directly involved...
Gut microbiota immaturity with DL-endopeptidase deficiency links antibiotic use to preterm late-onset sepsis [0.03%]
抗生素使用的肠道微生物群不成熟与DL-肽酶缺乏 linked to prematurity late-onset sepsis
Wei Shen,Huidi Wang,Jiaxuan Wang et al.
Wei Shen et al.
Early antibiotic exposure increases late-onset sepsis (LOS) risk in preterm infants, potentially via gut dysbiosis. Analyzing 4,938 longitudinal fecal samples from preterm infants in China, the US, and the UK, we identified a differential p...
Immune activation reprograms growth mRNA stability to shape plant growth-defense trade-offs [0.03%]
免疫激活重新编程生长mRNA稳定性以塑造植物生长防御贸易关系
Guilong Zhou,Ruixia Niu,Sitao Zhu et al.
Guilong Zhou et al.
Immune activation enhances defense gene expression but often suppresses plant growth, creating a fundamental trade-off that limits durable resistance. While selective translation of defense mRNAs has been reported, how growth mRNAs are regu...
Strain-level genetic heterogeneity and colonization dynamics drive microbiome therapeutic efficacy [0.03%]
菌株水平的遗传异质性和定植动力学驱动微生物组疗法的功效
Kai Chen,Yina Liu,Jie Rong et al.
Kai Chen et al.
Fecal microbiota transplantation (FMT) has shown immunotherapeutic promise, yet its efficacy in non-small-cell lung cancer (NSCLC) remains unclear. We demonstrate that FMT improves anti-PD-1 efficacy and progression-free survival in a singl...
Bacterial entrapment of a fungal carbon repressor prevents plant colonization [0.03%]
细菌困住真菌碳阻遏蛋白以阻止其植株定殖
Daiying Xu,Aliang Xia,Ruijie Huang et al.
Daiying Xu et al.
Carbon catabolite repression (CCR) acts as a switch, reprogramming nutrient utilization in fungal pathogens during the growth-to-colonization transition. However, whether this regulatory system can be exploited by other microbes remains unk...
Intratumoral bacterium Enterocloster bolteae promotes hepatocellular carcinoma progression by directly binding tumor cells [0.03%]
肠球菌门梭状芽胞杆菌科鲍特氏肠球菌通过直接结合肿瘤细胞促进肝癌进展
Xuxin Ren,Gaomin Zheng,Yuyao Liu et al.
Xuxin Ren et al.
The gut microbiota regulates systemic metabolism, inflammation, and immunity, with evidence linking microbiota translocation through the gut-liver axis to hepatocellular carcinoma (HCC) progression. However, the specific bacteria and underl...
Commensal enteric virome regulates intestinal carbohydrate digestion and absorption [0.03%]
共生肠道病毒组调节肠道碳水化合物的消化和吸收
Fengqing Lin,Lianglan Li,Yuanpeng He et al.
Fengqing Lin et al.
The enteric microbiome and nutrient sensing within the small intestine play critical roles in maintaining host metabolic homeostasis. Although various bacteria and some fungi have established functions in nutrient metabolism, the role of th...
An image-based transcriptomics atlas reveals the regional and microbiota-dependent molecular, cellular, and spatial structure of the murine gut [0.03%]
基于图像的转录组学图谱揭示了小鼠肠道区域和微生物群依赖性的分子、细胞和空间结构
Rosalind J Xu,Hao Zhang,Paolo Cadinu et al.
Rosalind J Xu et al.
The gastrointestinal environment is home to a massive diversity of diet-, host-, and microbiota-derived small molecules, collectively sensed by a remarkable variety of cells. To explore the cellular and spatial organization of sensation, we...
Single-cell profiling of the subgingival bacteria reveals transcriptional heterogeneity and niche-specific programs [0.03%]
单细胞剖析牙周细菌揭示了转录异质性和生态位特异性程序
Liguo Ding,Lu Song,Yibing Han et al.
Liguo Ding et al.
Periodontitis is a chronic inflammatory disease driven by subgingival dysbiosis. Despite progress in characterizing microbial diversity, functional heterogeneity at the single-cell level remains poorly understood, mainly due to challenges f...
Microbial communities in semi-mature oak trees are resilient to drought, nutrient limitation, and pathogen challenge [0.03%]
半成熟的橡树微生物群落在干旱、养分限制和病原体胁迫下具有较强的抗逆性
Usman Hussain,Marine C Cambon,Bridget Crampton et al.
Usman Hussain et al.
Global forest biomes face increasing stressors and disease outbreaks that threaten ecosystem health. Tree-associated microbiota are vital for tree resilience, yet their responses to biotic and abiotic stressors in mature trees remain poorly...