Discovery of human gut phage-encoded anti-CRISPR proteins unveils diverse mechanisms for phages to evade type II CRISPR immunity [0.03%]
人类肠道噬菌体编码的抗CRISPR蛋白的发现揭示了噬菌体逃避II型CRISPR免疫的多样化机制
Shengjian Yuan,Heng Zhu,Menghao Yu et al.
Shengjian Yuan et al.
Phages encode diverse anti-CRISPR (Acr) proteins to counteract bacterial CRISPR-Cas systems. However, gut phage Acrs remain poorly characterized. Using an integrated bioinformatics and high-throughput functional screening approach, we ident...
Intratumoral microbiota and host genotype cooperatively shape neutrophil cytotoxic functions in colorectal cancer [0.03%]
结直肠癌微环境中肿瘤微生物群和宿主基因型共同塑造中性粒细胞的细胞毒性功能
Elisa Sorrenti,Valeria Governa,Davide Bressan et al.
Elisa Sorrenti et al.
The role of tumor-associated neutrophils (TANs) infiltrating colorectal cancers (CRCs) is still debated. Here, we unravel that TAN recruitment and functions are modulated by intratumoral microbiota and only defined bacterial species can unl...
Cyriel Y Ponsioen,Hilde Herrema
Cyriel Y Ponsioen
Inflammatory bowel disease is associated with the gut microbiome, with many of its mechanistic underpinnings yet to be unraveled. In this issue of Cell Host & Microbe, Wen and colleagues show that Crohn's disease pathology is amplified by p...
Ye Peng,Dengwei Zhang,Hein M Tun
Ye Peng
The enteric virome, long overshadowed by bacteriome studies, is emerging as a direct modulator of host physiology. In this issue of Cell Host & Microbe, Lin and colleagues demonstrate that the enteric virome autonomously regulates carbohydr...
Gilad Bachrach,Wendy S Garrett
Gilad Bachrach
In this issue of Cell Host & Microbe, Sorrenti et al. reexamine fusobacteria's effects on colorectal cancer (CRC) outcomes, finding that Fusobacterium nucleatum (Fn) may not always be bad for patients. Their data suggest that a host's immun...
Zhijuan Tang,Suling Zeng
Zhijuan Tang
Microbial translocation via the gut-liver axis fuel hepatocarcinogenesis primarily through circulating microbial metabolites and molecular patterns. In this issue of Cell Host & Microbe, Ren et al. demonstrate that the liver bacteria Entero...
Candice Quin
Candice Quin
During infection, the immune system balances pathogen resistance with disease tolerance to mitigate damage. In a recent Nature paper, Sanchez and colleagues reveal that cardiac Foxo1-Trim63 protects young mice from polymicrobial sepsis but ...
Jana M Cable,Jacob S Yount
Jana M Cable
Influenza virus is associated with severe cardiac complications, yet mechanisms of disease, including how the virus traffics from lungs to the heart, have remained elusive. In a recent Immunity paper, Downey et al.1 demonstrate that pro-DC3...
Kawthar F Alashoor,Guan-Ting Erica Chen,Salim Al-Babili
Kawthar F Alashoor
How hosts integrate endogenous signaling pathways with antiviral defense remains poorly understood. In their recent Cell study, Yang et al. demonstrate that strigolactone signaling enhances resistance to rice grassy stunt virus, revealing a...
Leveraging intratumoral probiotics for pancreatic cancer immunotherapy via xenophagy [0.03%]
利用异嗜作用通过瘤内益生菌进行胰腺癌免疫治疗
Baoyi Li,Guangnian Liu,Yu Zhu et al.
Baoyi Li et al.
Although pancreatic ductal adenocarcinoma (PDAC) tumors harbor unique intracellular bacteria, therapeutic strategies to harness them and overcome immunotherapy resistance remain elusive. Through 16S rDNA sequencing of PDAC tumors from 40 pa...