Diversity-triggered 2-naphthoic acid exudation recruits keystone microbial taxa to promote soybean drought tolerance [0.03%]
大豆多样性触发释放2-萘甲酸招募关键微生物类群促进大豆抗旱性
Shi Chen,Yang Wang,Beibei Chen et al.
Shi Chen et al.
Rhizosphere microbiomes are essential for plant growth and stress tolerance, yet how microbial diversity shapes drought resilience in soybean remains unclear. Here, we demonstrate that high rhizosphere microbial diversity, generated via dil...
The DanRI regulatory system in uropathogenic Escherichia coli subverts neutrophil responses [0.03%]
致病性大肠杆菌的DanRI调控系统劫持中性粒细胞免疫反应
Dora Čerina,Matthieu Rousseau,Carla Hart Olaiz et al.
Dora Čerina et al.
Uropathogenic Escherichia coli (UPEC) is the primary cause of urinary tract infections (UTIs). To establish an infection, UPEC must evade infiltrating neutrophils and their antimicrobial neutrophil extracellular traps (NETs). In this study,...
Bacterial 2',3'-cGAMP activates a SAVED effector to form membrane-disrupting filaments and restrict phage replication [0.03%]
细菌2',3'-cGAMP激活SAVED效应物形成穿膜丝以限制噬菌体复制
Uday Tak,Kate Schinkel,Peace Walth et al.
Uday Tak et al.
Mammalian cells initiate antiviral signaling when cyclic GMP-AMP synthase (cGAS) detects cytoplasmic DNA and synthesizes 2',3'-cyclic GMP-AMP (2',3'-cGAMP), which activates stimulator of interferon genes (STING). Similarly, bacteria use cyc...
The skin microbiota drives cutaneous immune checkpoint inhibitor toxicity in genetically susceptible mice [0.03%]
皮肤微生物群驱动遗传易感小鼠免疫检查点抑制剂的毒性反应
Vanessa Salazar,Scott T Espenschied,Anthony P Fernandez et al.
Vanessa Salazar et al.
Immune checkpoint inhibitors (ICIs) show increasing promise for cancer therapy. However, patients can experience adverse events, particularly those with pre-existing autoimmune disease. We determined that the microbiome can drive ICI-induce...
Vaginal microbiota impacts of a Lactobacillus crispatus live biotherapeutic and predictors of colonization in randomized controlled trial [0.03%]
一项随机对照试验中乳酸菌布拉氏酵母菌活体生物治疗产品对阴道微生态的影响及定植预测因素
Seth M Bloom,Laura Symul,Joseph Elsherbini et al.
Seth M Bloom et al.
Bacterial vaginosis (BV) affects >25% of women worldwide and often recurs after standard-of-care metronidazole (MTZ) treatment. LACTIN-V, a live biotherapeutic product (LBP) containing Lactobacillus crispatus strain CTV-05, significantly re...
Gut microbiota-derived indole-3-lactic acid suppresses anti-PD-1 efficacy in esophageal squamous cell carcinoma [0.03%]
肠道微生物群衍生的吲哚-3-乳酸通过抑制效应T细胞功能削弱抗PD-1疗效
Jianfeng Zhou,Xiaoxi Zeng,Jun Sun et al.
Jianfeng Zhou et al.
Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy where the efficacy of anti-PD-1 immunotherapy varies among individuals, possibly influenced by the gut microbiota. Here, we analyze 122 fecal samples from ESCC pati...
Gut pathogen Clostridium symbiosum rewires macrophage succinylation to drive enteric neuron loss in inflammatory bowel disease [0.03%]
肠道病原体Clostridium symbiosum通过重新布线巨噬细胞琥珀酰化作用来驱动炎症性肠病中的肠神经元丧失
Ying Zhao,Lijun Ning,Yuqing Yan et al.
Ying Zhao et al.
Inflammatory bowel disease (IBD) is a chronic relapsing and remitting disorder in which loss of intrinsic enteric neurons (iENs) has been documented. However, the contribution of gut microbiota to the loss of iENs in IBD remains poorly defi...
Human monoclonal antibodies isolated after seasonal vaccination broadly neutralize antigenically drifted influenza B viruses [0.03%]
季节性流感疫苗接种后分离的单克隆抗体可广谱中和抗原漂移的乙型流感病毒
Xiaoyu Cai,Miao Fan,Yanmei Zhai et al.
Xiaoyu Cai et al.
Antigenic drift in hemagglutinin (HA) enables influenza viruses to escape host immunity. Elucidating molecular features of antigenic drift is essential for updating seasonal vaccines and pandemic preparedness. Here, we found that influenza ...
Glycogen phosphorylase L confers metabolic flexibility in neutrophils to fight fungal infections in nutrient-deprived tissues [0.03%]
糖原磷酸化酶L赋予中性粒细胞代谢灵活性以对抗营养物质匮乏组织中的真菌感染
Wonseok Choi,De-Dong Li,Colin T McLaughlin et al.
Wonseok Choi et al.
Neutrophils are crucial for defense against systemic Candida albicans infections and rely on glucose for their antifungal functions, including the production of reactive oxygen species (ROS) and neutrophil extracellular traps (NETs). In inf...
VIBRANT: A phase 1 randomized trial of multi-strain vaginal L. crispatus live biotherapeutic products in people with bacterial vaginosis [0.03%]
VIBRANT：一种相1期随机试验：多菌株活生物治疗产品用于细菌性阴道病患者的乳酸杆菌防治试验
Disebo Potloane,Laura Symul,Sinaye Ngcapu et al.
Disebo Potloane et al.
Bacterial vaginosis (BV) is characterized by high microbial diversity. High recurrence rates following antibiotics may stem from poor recolonization by protective Lactobacillus species. This phase 1 randomized trial in the United States and...