Kanta Subbarao
Kanta Subbarao
The rapid and remarkably successful development, manufacture, and deployment of several effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines is now tempered by three key challenges. First, reducing virus transmiss...
Beau Schaeffer,Bradford Taylor,Mary Bushman et al.
Beau Schaeffer et al.
If enough individuals in a population are immune to a pathogen, it cannot cause an outbreak. Deliberately seeking such herd immunity through infection during a potentially lethal pandemic is contrary to all principles of public health, give...
Miriam Merad,Aruna Subramanian,Taia T Wang
Miriam Merad
Severe COVID-19 arises from the convergence of inadequate pre-existing immunity and a host response that damages, rather than repairs, tissues. We outline clinical presentations of COVID-19 that are likely driven by dysregulated host immuni...
Dusan Bogunovic,Miriam Merad
Dusan Bogunovic
A previously immune-naive world population is experiencing natural infection with SARS-CoV-2. Severe COVID-19 predominantly impacts adults, yet multisystem inflammatory disorder primarily impacts children. Herein, we discuss known clinical ...
Global COVID-19 vaccine inequity: The scope, the impact, and the challenges [0.03%]
全球新冠肺炎疫苗分配不公：范围、影响及挑战
Archana Asundi,Colin O&#x;Leary,Nahid Bhadelia
Archana Asundi
Global vaccine inequity is prolonging the COVID-19 pandemic. Here, we outline the scope and impact of inequitable vaccine distribution and identify challenges in vaccine development, manufacturing, and distribution as well as potential solu...
Payal Damani-Yokota,Stephen T Yeung,Kamal M Khanna
Payal Damani-Yokota
Mounting a robust immune response against SARS-CoV-2 requires neutralization as well as effector T cell functions. In this issue of Cell Host Microbe, Tauzin et al. characterize the humoral and T cell responses after a single dose of BNT162...
Arinjay Banerjee
Arinjay Banerjee
The likely animal source of SARS-CoV-2 remains speculative. A recent study published in Cell by Zhou et al. reported the detection of novel alpha- and betacoronaviruses, including SARS-CoV-2-related viruses in bats. ...
HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens [0.03%]
艾滋病毒和新冠病毒：两种大流行病原体进化中的相似性
Will Fischer,Elena E Giorgi,Srirupa Chakraborty et al.
Will Fischer et al.
Humanity is currently facing the challenge of two devastating pandemics caused by two very different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which has swept the world in the course of a single year. The same ...
SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19 [0.03%]
人T细胞表位:SARS-CoV-2适应性免疫应答对抗COVID-19
Alba Grifoni,John Sidney,Randi Vita et al.
Alba Grifoni et al.
Over the past year, numerous studies in the peer reviewed and preprint literature have reported on the virological, epidemiological and clinical characteristics of the coronavirus, SARS-CoV-2. To date, 25 studies have investigated and ident...
Global mapping of Salmonella enterica-host protein-protein interactions during infection [0.03%]
感染期间绘制沙门氏菌-宿主蛋白质相互作用的全球地图
Philipp Walch,Joel Selkrig,Leigh A Knodler et al.
Philipp Walch et al.
Intracellular bacterial pathogens inject effector proteins to hijack host cellular processes and promote their survival and proliferation. To systematically map effector-host protein-protein interactions (PPIs) during infection, we generate...