Non-canonical helical transitions and conformational switching are associated with characteristic flexibility and disorder indices in TRP and Kv channels [0.03%]
TRP和Kv通道中非典型螺旋转换和构象跃迁与特征灵活性和无序性指标相关
Abigail García-Morales,Daniel Balleza
Abigail García-Morales
Structural evidence and much experimental data have demonstrated the presence of non-canonical helical substructures (π and 310) in regions of great functional relevance both in TRP as in Kv channels. Through an exhaustive compositional an...
The influence of Nav1.9 channels on intestinal hyperpathia and dysmotility [0.03%]
Nav1.9通道对肠高敏和动力异常的影响研究进展
Chenyu Zhao,Xi Zhou,Xiaoliu Shi
Chenyu Zhao
The Nav1.9 channel is a voltage-gated sodium channel. It plays a vital role in the generation of pain and the formation of neuronal hyperexcitability after inflammation. It is highly expressed in small diameter neurons of dorsal root gangli...
Identification of SLC2A3 as a prognostic indicator correlated with the NF-κB/EMT axis and immune response in head and neck squamous cell carcinoma [0.03%]
SLC2A3作为头颈鳞状细胞癌预后指示物与NF-κB/上皮间质转化轴及免疫反应相关性的鉴定
Fangyu Chai,Jingfang Zhang,Tao Fu et al.
Fangyu Chai et al.
SLC2A3 is an important member of the glucose transporter superfamily. It has been recently suggested that upregulation of SLC2A3 is associated with poor survival and acts as a prognostic marker in a variety of tumors. Unfortunately, the pro...
A governance of ion selectivity based on the occupancy of the "beacon" in one- and four-domain calcium and sodium channels [0.03%]
基于“信标”占据的一域和四域钙通道及钠通道的离子选择性管理规则
J David Spafford
J David Spafford
One of nature's exceptions was discovered when a Cav3 T-type channel was observed to switch phenotype from a calcium channel into a sodium channel by neutralizing an aspartate residue in the high field strength (HFS) +1 position within the ...
Zhuqing Xie,Nashat Abumaria
Zhuqing Xie
Transient receptor potential melastatin-like 7 (TRPM7) is a key player in various physiological and pathological processes. TRPM7 channel activity is regulated by different factors. The effects of cleavage of different domains on channel ac...
Fibrillin-1 mutation contributes to Marfan syndrome by inhibiting Cav1.2-mediated cell proliferation in vascular smooth muscle cells [0.03%]
突变的纤维蛋白原-1通过抑制血管平滑肌细胞中Cav1.2介导的细胞增殖促进马方综合征的发展
Wenfeng Lin,Jiaqi Xiong,Yefan Jiang et al.
Wenfeng Lin et al.
Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutation in fibrillin-1 (FBN1). However, the molecular mechanism underlying MFS remains poorly understood. The study aimed to explore how the L-type calcium...
Characterization of two pathological gating-charge substitutions in Cav1.4 L-type calcium channels [0.03%]
CaV1.4 L型钙通道两种病理性闸控电荷替代的特征分析
Thomas Heigl,Michael A Netzer,Lucia Zanetti et al.
Thomas Heigl et al.
Cav1.4 L-type calcium channels are predominantly expressed at the photoreceptor terminals and in bipolar cells, mediating neurotransmitter release. Mutations in its gene, CACNA1F, can cause congenital stationary night-blindness type 2 (CSNB...
Bibliometric analysis of recent research on the association between TRPV1 and inflammation [0.03%]
TRPV1与炎症相关性近期研究的 bibliometriks 分析
Pan Xu,Ru-Ru Shao,Yuan He
Pan Xu
TRPV1 channel is a sensitive ion channel activated by some noxious stimuli and has been reported to change many physiological functions after its activation. In this paper, we present a scientometric approach to explore the trends of the as...
Karl Kunzelmann,Raquel Centeio,Jiraporn Ousingsawat et al.
Karl Kunzelmann et al.
SLC26A9 is one out of 11 proteins that belong to the SLC26A family of anion transporters. Apart from expression in the gastrointestinal tract, SLC26A9 is also found in the respiratory system, in male tissues and in the skin. SLC26A9 has gai...
L-type calcium channels and neuropsychiatric diseases: Insights into genetic risk variant-associated genomic regulation and impact on brain development [0.03%]
L型钙通道与神经精神疾病：遗传风险变异体相关基因调控机制及其对脑发育的影响
Madelyn R Baker,Andrew S Lee,Anjali M Rajadhyaksha
Madelyn R Baker
Recent human genetic studies have linked a variety of genetic variants in the CACNA1C and CACNA1D genes to neuropsychiatric and neurodevelopmental disorders. This is not surprising given the work from multiple laboratories using cell and an...