Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels [0.03%]
环核苷酸门控通道的结构基础及其功能和离子通道病机制
Zhengshan Hu,Jian Yang
Zhengshan Hu
Recent years have seen an outpouring of atomic or near atomic resolution structures of cyclic nucleotide-gated (CNG) channels, captured in closed, transition, pre-open, partially open, and fully open states. These structures provide unprece...
The role of ATP binding cassette (ABC) transporters in breast cancer: Evaluating prognosis, predicting immunity, and guiding treatment [0.03%]
ATP结合盒转运蛋白（ABC）在乳腺癌中的作用：评估预后、预测免疫和指导治疗
Yuan Yuan,Zhouhong Xiang,Yuhua Xia et al.
Yuan Yuan et al.
Breast cancer is currently the most prevalent form of cancer worldwide. Nevertheless, there remains limited clarity regarding our understanding of the tumor microenvironment and metabolic characteristics associated with it. ATP-binding cass...
Arthur Neuberger,Alexander I Sobolevsky
Arthur Neuberger
TRPV6, a representative of the vanilloid subfamily of TRP channels, serves as the principal calcium uptake channel in the gut. Dysregulation of TRPV6 results in disturbed calcium homeostasis leading to a variety of human diseases, including...
Type 3 IP3 receptor: Its structure, functions, and related disease implications [0.03%]
IP3受体3型：结构、功能及其与相关疾病的联系
Lvying Wu,Jin Chen
Lvying Wu
Cell-fate decisions depend on the precise and strict regulation of multiple signaling molecules and transcription factors, especially intracellular Ca2+ homeostasis and dynamics. Type 3 inositol 1,4,5-triphosphate receptor (IP3R3) is an a t...
Overlap in synaptic neurological condition susceptibility pathways and the neural pannexin 1 interactome revealed by bioinformatics analyses [0.03%]
生物信息学分析揭示了神经病理条件易感途径和神经型PANX1互作网络的重叠性
Simona D Frederiksen,Leigh E Wicki-Stordeur,Leigh Anne Swayne
Simona D Frederiksen
Many neurological conditions exhibit synaptic impairments, suggesting mechanistic convergence. Additionally, the pannexin 1 (PANX1) channel and signaling scaffold is linked to several of these neurological conditions and is an emerging regu...
Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads [0.03%]
电压门控钾通道KV1.3的结构：失活构象及与治疗先导化合物结合的见解
K George Chandy,Karoline Sanches,Raymond S Norton
K George Chandy
The voltage-gated potassium channel KV1.3 is an important therapeutic target for the treatment of autoimmune and neuroinflammatory diseases. The recent structures of KV1.3, Shaker-IR (wild-type and inactivating W434F mutant) and an inactiva...
TMEM120A/TACAN: A putative regulator of ion channels, mechanosensation, and lipid metabolism [0.03%]
新型机械敏感离子通道TMEM120A/TACAN可能是脂代谢调节因子
Matthew Gabrielle,Tibor Rohacs
Matthew Gabrielle
TMEM120A (TACAN) is an enigmatic protein with several seemingly unconnected functions. It was proposed to be an ion channel involved in sensing mechanical stimuli, and knockdown/knockout experiments have implicated that TMEM120A may be nece...
Advancements in the study of inward rectifying potassium channels on vascular cells [0.03%]
血管内向整流型钾通道的研究进展
Chunshu Li,Yan Yang
Chunshu Li
Inward rectifier potassium channels (Kir channels) exist in a variety of cells and are involved in maintaining resting membrane potential and signal transduction in most cells, as well as connecting metabolism and membrane excitability of b...
Secretory carrier-associated membrane protein 5 regulates cell-surface targeting of T-type calcium channels [0.03%]
分泌相关膜蛋白5调节T型电压门控钙通道的细胞表面定位
Emilio R Mustafá,Konstantin Weiß,Norbert Weiss
Emilio R Mustafá
Missense mutations in the human secretary carrier-associated membrane protein 5 (SCAMP5) cause a variety of neurological disorders including neurodevelopmental delay, epilepsy, and Parkinson's disease. We recently documented the importance ...
Cycling matters: Sex hormone regulation of vascular potassium channels [0.03%]
Cycling matters：性激素对血管钾通道的调节作用
Samuel N Baldwin,Thomas A Jepps,Iain A Greenwood
Samuel N Baldwin
Sex hormones and the reproductive cycle (estrus in rodents and menstrual in humans) have a known impact on arterial function. In spite of this, sex hormones and the estrus/menstrual cycle are often neglected experimental factors in vascular...