Voltage gated sodium and calcium channels: Discovery, structure, function, and Pharmacology [0.03%]
电压门控钠和钙通道：发现、结构、功能及药理学
William A Catterall
William A Catterall
Voltage-gated sodium channels initiate action potentials in nerve and muscle, and voltage-gated calcium channels couple depolarization of the plasma membrane to intracellular events such as secretion, contraction, synaptic transmission, and...
Transient receptor potential vanilloid type 1: cardioprotective effects in diabetic models [0.03%]
瞬时受体电位香草素型离子通道1在糖尿病模型中的心肌保护作用
Jiaqi Bao,Zhicheng Gao,Yilan Hu et al.
Jiaqi Bao et al.
Cardiovascular disease, especially heart failure (HF) is the leading cause of death in patients with diabetes. Individuals with diabetes are prone to a special type of cardiomyopathy called diabetic cardiomyopathy (DCM), which cannot be exp...
A systemic analysis of monocarboxylate transporters in ovarian cancer and possible therapeutic interventions [0.03%]
卵巢癌中单羧酸转运蛋白的系统分析及其可能的治疗干预措施
Priti Chatterjee,Debaleena Bhowmik,Sib Sankar Roy
Priti Chatterjee
Monocarboxylate transporters (MCTs) play an immense role in metabolically active solid tumors by regulating concentration-dependent transport of different important monocarboxylates including pyruvate and lactate and are encoded by the SLC1...
Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels [0.03%]
环核苷酸门控通道的结构基础及其功能和离子通道病机制
Zhengshan Hu,Jian Yang
Zhengshan Hu
Recent years have seen an outpouring of atomic or near atomic resolution structures of cyclic nucleotide-gated (CNG) channels, captured in closed, transition, pre-open, partially open, and fully open states. These structures provide unprece...
The role of ATP binding cassette (ABC) transporters in breast cancer: Evaluating prognosis, predicting immunity, and guiding treatment [0.03%]
ATP结合盒转运蛋白（ABC）在乳腺癌中的作用：评估预后、预测免疫和指导治疗
Yuan Yuan,Zhouhong Xiang,Yuhua Xia et al.
Yuan Yuan et al.
Breast cancer is currently the most prevalent form of cancer worldwide. Nevertheless, there remains limited clarity regarding our understanding of the tumor microenvironment and metabolic characteristics associated with it. ATP-binding cass...
Arthur Neuberger,Alexander I Sobolevsky
Arthur Neuberger
TRPV6, a representative of the vanilloid subfamily of TRP channels, serves as the principal calcium uptake channel in the gut. Dysregulation of TRPV6 results in disturbed calcium homeostasis leading to a variety of human diseases, including...
Type 3 IP3 receptor: Its structure, functions, and related disease implications [0.03%]
IP3受体3型：结构、功能及其与相关疾病的联系
Lvying Wu,Jin Chen
Lvying Wu
Cell-fate decisions depend on the precise and strict regulation of multiple signaling molecules and transcription factors, especially intracellular Ca2+ homeostasis and dynamics. Type 3 inositol 1,4,5-triphosphate receptor (IP3R3) is an a t...
Overlap in synaptic neurological condition susceptibility pathways and the neural pannexin 1 interactome revealed by bioinformatics analyses [0.03%]
生物信息学分析揭示了神经病理条件易感途径和神经型PANX1互作网络的重叠性
Simona D Frederiksen,Leigh E Wicki-Stordeur,Leigh Anne Swayne
Simona D Frederiksen
Many neurological conditions exhibit synaptic impairments, suggesting mechanistic convergence. Additionally, the pannexin 1 (PANX1) channel and signaling scaffold is linked to several of these neurological conditions and is an emerging regu...
Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads [0.03%]
电压门控钾通道KV1.3的结构：失活构象及与治疗先导化合物结合的见解
K George Chandy,Karoline Sanches,Raymond S Norton
K George Chandy
The voltage-gated potassium channel KV1.3 is an important therapeutic target for the treatment of autoimmune and neuroinflammatory diseases. The recent structures of KV1.3, Shaker-IR (wild-type and inactivating W434F mutant) and an inactiva...
TMEM120A/TACAN: A putative regulator of ion channels, mechanosensation, and lipid metabolism [0.03%]
新型机械敏感离子通道TMEM120A/TACAN可能是脂代谢调节因子
Matthew Gabrielle,Tibor Rohacs
Matthew Gabrielle
TMEM120A (TACAN) is an enigmatic protein with several seemingly unconnected functions. It was proposed to be an ion channel involved in sensing mechanical stimuli, and knockdown/knockout experiments have implicated that TMEM120A may be nece...