Ion channel-mediated mitochondrial volume regulation and its relationship with mitochondrial dynamics [0.03%]
离子通道介导的线粒体容积调节及其与线粒体动力学的关系
Yujia Zhuang,Wenting Jiang,Zhe Zhao et al.
Yujia Zhuang et al.
The mitochondrion, one of the important cellular organelles, has the major function of generating adenosine triphosphate and plays an important role in maintaining cellular homeostasis, governing signal transduction, regulating membrane pot...
Dynamic duo: Kir6 and SUR in KATP channel structure and function [0.03%]
动态二人组：KATP通道的结构与功能中的Kir6和SUR蛋白
Bruce L Patton,Phillip Zhu,Assmaa ElSheikh et al.
Bruce L Patton et al.
KATP channels are ligand-gated potassium channels that couple cellular energetics with membrane potential to regulate cell activity. Each channel is an eight subunit complex comprising four central pore-forming Kir6 inward rectifier potassi...
Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold [0.03%]
使用AlphaFold2、RoseTTAFold2和ESMFold建模离子通道的结构
Phuong Tran Nguyen,Brandon John Harris,Diego Lopez Mateos et al.
Phuong Tran Nguyen et al.
Ion channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding of the molecular mechanisms of channel gat...
Recent advances on the structure and the function relationships of the TRPV4 ion channel [0.03%]
TRPV4离子通道的结构与功能关系的研究进展
Raúl Sánchez-Hernández,Miguel Benítez-Angeles,Ana M Hernández-Vega et al.
Raúl Sánchez-Hernández et al.
The members of the superfamily of Transient Receptor Potential (TRP) ion channels are physiologically important molecules that have been studied for many years and are still being intensively researched. Among the vanilloid TRP subfamily, t...
A phenylalanine at the extracellular side of Kir1.1 facilitates potassium permeation [0.03%]
Kir1.1胞外侧的苯丙氨酸促进钾离子转运
Henry Sackin,Mikheil Nanazashvili
Henry Sackin
The Kir1.1 (ROMK) family of weak inward rectifiers controls K secretion in the renal CCT and K recycling in the renal TALH. A single point mutant of the inward rectifier, F127V-Kir1.1b was used to investigate the K transition between the se...
Damayantee Das,Anson Wong,Timothy N Friedman et al.
Damayantee Das et al.
The patch clamp method is a widely applied electrophysiological technique used to understand ion channel activity and cellular excitation. The formation of a high resistance giga-ohm seal is required to obtain high-quality recordings but ca...
Novel insights into voltage-gated ion channels: Translational breakthroughs in medical oncology [0.03%]
电压门控离子通道的新认识：医学肿瘤学中的转化突破
Minas Sakellakis,Sung Mi Yoon,Jashan Reet et al.
Minas Sakellakis et al.
Preclinical evidence suggests that voltage gradients can act as a kind of top-down master regulator during embryogenesis and orchestrate downstream molecular-genetic pathways during organ regeneration or repair. Moreover, electrical stimula...
Xia Yao,Shuai Gao,Nieng Yan
Xia Yao
Voltage-gated calcium (Cav) channels mediate Ca2+ influx in response to membrane depolarization, playing critical roles in diverse physiological processes. Dysfunction or aberrant regulation of Cav channels can lead to life-threatening cons...
Sodium currents in naïve mouse dorsal root ganglion neurons: No major differences between sexes [0.03%]
未经处理的小鼠背根神经节神经元中的钠电流：性别之间无显著差异
Mohammad-Reza Ghovanloo,Sidharth Tyagi,Peng Zhao et al.
Mohammad-Reza Ghovanloo et al.
Sexual dimorphism has been reported in multiple pre-clinical and clinical studies on pain. Previous investigations have suggested that in at least some states, rodent dorsal root ganglion (DRG) neurons display differential sex-dependent reg...
Zhangqiang Li,Qiurong Wu,Nieng Yan
Zhangqiang Li
Voltage-gated sodium (Nav) channels govern membrane excitability by initiating and propagating action potentials. Consistent with their physiological significance, dysfunction, or mutations in these channels are associated with various chan...