Recent advances on the structure and the function relationships of the TRPV4 ion channel [0.03%]
TRPV4离子通道的结构与功能关系的研究进展
Raúl Sánchez-Hernández,Miguel Benítez-Angeles,Ana M Hernández-Vega et al.
Raúl Sánchez-Hernández et al.
The members of the superfamily of Transient Receptor Potential (TRP) ion channels are physiologically important molecules that have been studied for many years and are still being intensively researched. Among the vanilloid TRP subfamily, t...
A phenylalanine at the extracellular side of Kir1.1 facilitates potassium permeation [0.03%]
Kir1.1胞外侧的苯丙氨酸促进钾离子转运
Henry Sackin,Mikheil Nanazashvili
Henry Sackin
The Kir1.1 (ROMK) family of weak inward rectifiers controls K secretion in the renal CCT and K recycling in the renal TALH. A single point mutant of the inward rectifier, F127V-Kir1.1b was used to investigate the K transition between the se...
Damayantee Das,Anson Wong,Timothy N Friedman et al.
Damayantee Das et al.
The patch clamp method is a widely applied electrophysiological technique used to understand ion channel activity and cellular excitation. The formation of a high resistance giga-ohm seal is required to obtain high-quality recordings but ca...
Novel insights into voltage-gated ion channels: Translational breakthroughs in medical oncology [0.03%]
电压门控离子通道的新认识：医学肿瘤学中的转化突破
Minas Sakellakis,Sung Mi Yoon,Jashan Reet et al.
Minas Sakellakis et al.
Preclinical evidence suggests that voltage gradients can act as a kind of top-down master regulator during embryogenesis and orchestrate downstream molecular-genetic pathways during organ regeneration or repair. Moreover, electrical stimula...
Xia Yao,Shuai Gao,Nieng Yan
Xia Yao
Voltage-gated calcium (Cav) channels mediate Ca2+ influx in response to membrane depolarization, playing critical roles in diverse physiological processes. Dysfunction or aberrant regulation of Cav channels can lead to life-threatening cons...
Sodium currents in naïve mouse dorsal root ganglion neurons: No major differences between sexes [0.03%]
未经处理的小鼠背根神经节神经元中的钠电流：性别之间无显著差异
Mohammad-Reza Ghovanloo,Sidharth Tyagi,Peng Zhao et al.
Mohammad-Reza Ghovanloo et al.
Sexual dimorphism has been reported in multiple pre-clinical and clinical studies on pain. Previous investigations have suggested that in at least some states, rodent dorsal root ganglion (DRG) neurons display differential sex-dependent reg...
Zhangqiang Li,Qiurong Wu,Nieng Yan
Zhangqiang Li
Voltage-gated sodium (Nav) channels govern membrane excitability by initiating and propagating action potentials. Consistent with their physiological significance, dysfunction, or mutations in these channels are associated with various chan...
Voltage gated sodium and calcium channels: Discovery, structure, function, and Pharmacology [0.03%]
电压门控钠和钙通道：发现、结构、功能及药理学
William A Catterall
William A Catterall
Voltage-gated sodium channels initiate action potentials in nerve and muscle, and voltage-gated calcium channels couple depolarization of the plasma membrane to intracellular events such as secretion, contraction, synaptic transmission, and...
Transient receptor potential vanilloid type 1: cardioprotective effects in diabetic models [0.03%]
瞬时受体电位香草素型离子通道1在糖尿病模型中的心肌保护作用
Jiaqi Bao,Zhicheng Gao,Yilan Hu et al.
Jiaqi Bao et al.
Cardiovascular disease, especially heart failure (HF) is the leading cause of death in patients with diabetes. Individuals with diabetes are prone to a special type of cardiomyopathy called diabetic cardiomyopathy (DCM), which cannot be exp...
A systemic analysis of monocarboxylate transporters in ovarian cancer and possible therapeutic interventions [0.03%]
卵巢癌中单羧酸转运蛋白的系统分析及其可能的治疗干预措施
Priti Chatterjee,Debaleena Bhowmik,Sib Sankar Roy
Priti Chatterjee
Monocarboxylate transporters (MCTs) play an immense role in metabolically active solid tumors by regulating concentration-dependent transport of different important monocarboxylates including pyruvate and lactate and are encoded by the SLC1...