Ionotropic purinergic receptor 7 (P2X7) channel structure and pharmacology provides insight regarding non-nucleotide agonism [0.03%]
离子otropic嘌呤受体7（P2X7）通道结构和药理学为非核苷酸激动提供见解
Rua&#x;a Al-Aqtash,Daniel M Collier
Rua&#x;a Al-Aqtash
P2X7 is a member of the Ionotropic Purinergic Receptor (P2X) family. The P2X family of receptors is composed of seven (P2X1-7), ligand-gated, nonselective cation channels. Changes in P2X expression have been reported in multiple disease mod...
Cardiac L-type calcium channel regulation by Leucine-Rich Repeat-Containing Protein 10 [0.03%]
富含亮氨酸的重复蛋白10对心脏L型钙通道的调节作用
Natthaphat Siri-Angkul,Timothy J Kamp
Natthaphat Siri-Angkul
L-type calcium channels (LTCCs), the major portal for Ca2+ entry into cardiomyocytes, are essential for excitation-contraction coupling and thus play a central role in regulating overall cardiac function. LTCC function is finely tuned by mu...
The activation thresholds and inactivation kinetics of poking-evoked PIEZO1 and PIEZO2 currents are sensitive to subtle variations in mechanical stimulation parameters [0.03%]
PIEZO1和PIEZO2电流的激活阈值和失活动力学对机械刺激参数的细微变化敏感
Nadja Zeitzschel,Stefan G Lechner
Nadja Zeitzschel
PIEZO1 and PIEZO2 are mechanically activated ion channels that confer mechanosensitivity to various cell types. PIEZO channels are commonly examined using the so-called poking technique, where currents are recorded in the whole-cell configu...
Clinical and genetic characteristics of myotonia congenita in Chinese population [0.03%]
中国先天性肌强直的临床和遗传特征分析
Yuting He,Yusen Qiu,Ying Xiong et al.
Yuting He et al.
Myotonia congenita (MC) is a rare hereditary muscle disease caused by variants in the CLCN1 gene. Currently, the correlation of phenotype-genotype is still uncertain between dominant-type Thomsen (TMC) and recessive-type Becker (BMC). The c...
Role of the CaV1.2 distal carboxy terminus in the regulation of L-type current [0.03%]
CaV1.2羧基端末端在L型电流调节中的作用
Felipe Arancibia,Daniela De Giorgis,Franco Medina et al.
Felipe Arancibia et al.
L-type calcium channels are essential for the excitation-contraction coupling in cardiac muscle. The CaV1.2 channel is the most predominant isoform in the ventricle which consists of a multi-subunit membrane complex that includes the CaV1.2...
Michael Trus,Daphne Atlas
Michael Trus
Voltage-gated calcium channels (VGCCs) are the major conduits for calcium ions (Ca2+) within excitable cells. Recent studies have highlighted the non-ionotropic functionality of VGCCs, revealing their capacity to activate intracellular path...
Novel protocol for multiple-dose oral administration of the L-type Ca2+ channel blocker isradipine in mice: A dose-finding pharmacokinetic study [0.03%]
一种新型方案用于小鼠多次口服给药L型Ca2+通道阻断剂伊拉地平的药代动力学剂量探索研究
Tamara Theiner,Nadine J Ortner,Herbert Oberacher et al.
Tamara Theiner et al.
Studies in genetically modified animals and human genetics have recently provided new insight into the role of voltage-gated L-type Ca2+ channels in human disease. Therefore, the inhibition of L-type Ca2+ channels in vivo in wildtype and mu...
Ion channel-mediated mitochondrial volume regulation and its relationship with mitochondrial dynamics [0.03%]
离子通道介导的线粒体容积调节及其与线粒体动力学的关系
Yujia Zhuang,Wenting Jiang,Zhe Zhao et al.
Yujia Zhuang et al.
The mitochondrion, one of the important cellular organelles, has the major function of generating adenosine triphosphate and plays an important role in maintaining cellular homeostasis, governing signal transduction, regulating membrane pot...
Dynamic duo: Kir6 and SUR in KATP channel structure and function [0.03%]
动态二人组：KATP通道的结构与功能中的Kir6和SUR蛋白
Bruce L Patton,Phillip Zhu,Assmaa ElSheikh et al.
Bruce L Patton et al.
KATP channels are ligand-gated potassium channels that couple cellular energetics with membrane potential to regulate cell activity. Each channel is an eight subunit complex comprising four central pore-forming Kir6 inward rectifier potassi...
Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold [0.03%]
使用AlphaFold2、RoseTTAFold2和ESMFold建模离子通道的结构
Phuong Tran Nguyen,Brandon John Harris,Diego Lopez Mateos et al.
Phuong Tran Nguyen et al.
Ion channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding of the molecular mechanisms of channel gat...