Biophysical and structural mechanisms of epilepsy-associated mutations in the S4-S5 Linker of KCNQ2 channels [0.03%]
与癫痫相关的KCNQ2通道S4-S5连接区突变的生物物理和结构机制
Inn-Chi Lee,Yen-Yu Yang,Hsueh-Kai Chang et al.
Inn-Chi Lee et al.
Mutations in KCNQ2 are linked to various neurological disorders, including neonatal-onset epilepsy. The severity of these conditions often correlates with the mutation's location and the biochemical properties of the altered amino acid side...
The endocannabinoid ARA-S facilitates the activation of cardiac Kv7.1/KCNE1 channels from different species [0.03%]
内源大麻素ARA-S促进不同物种心脏Kv7.1/KCNE1通道的激活
Irene Hiniesto-Iñigo,Veronika A Linhart,Ali S Kusay et al.
Irene Hiniesto-Iñigo et al.
The endogenous endocannabinoid-like compound N-arachidonoyl-L-serine (ARA-S) facilitates activation of the human Kv7.1/KCNE1 channel and shortens a prolonged action potential duration and QT interval in guinea pig hearts. Hence, ARA-S is in...
The role and mechanism of vascular wall cell ion channels in vascular fibrosis remodeling [0.03%]
血管壁细胞离子通道在血管纤维化重塑中的作用及机制研究
Xiaolin Zhang,Hai Tian,Cheng Xie et al.
Xiaolin Zhang et al.
Fibrosis is usually the final pathological state of many chronic inflammatory diseases and may lead to organ malfunction. Excessive deposition of extracellular matrix (ECM) molecules is a characteristic of most fibrotic tissues. The blood v...
Binding kinetics of quaternary ammonium ions in Kcv potassium channels [0.03%]
四烷基铵离子与Kcv钾通道的结合动力学研究
Tobias Korn,Ulf-Peter Hansen,Tobias Sebastian Gabriel et al.
Tobias Korn et al.
Kcv channels from plant viruses represent the autonomous pore module of potassium channels, devoid of any regulatory domains. These small proteins show very reproducible single-channel behavior in planar lipid bilayers. Thus, they are an op...
Characterization of four structurally diverse inhibitors of SUR2-containing KATP channels [0.03%]
四种结构各异的SUR2含有的KATP通道抑制剂的特点分析
Kangjun Li,Vaishali Satpute Janve,Jerod Denton
Kangjun Li
Vascular smooth muscle ATP-sensitive potassium (KATP) channels play critical roles in modulating vascular tone and thus represent important drug targets for diverse cardiovascular pathologies. Despite extensive research efforts spanning sev...
Piezo1 channel: A global bibliometric analysis from 2010 to 2024 [0.03%]
Piezo1通道：2010年至2024年的全球文献计量分析
Chuanxi Tian,Tianyi Lyu,Xirui Zhao et al.
Chuanxi Tian et al.
In recent years, the Piezo1 channel has attracted great attention. Piezo1's research has made remarkable advance in many aspects. However, the overall trends and knowledge structures have not been systematically investigated from a worldwid...
Evaluation of four KCNMA1 channelopathy variants on BK channel current under CaV1.2 activation [0.03%]
四种KCNN4基因变异体在CaV1.2激活时对大电导钙激活钾通道电流的影响评估
Ria L Dinsdale,Andrea L Meredith
Ria L Dinsdale
Variants in KCNMA1, encoding the voltage- and calcium-activated K+ (BK) channel, are associated with human neurological disease. The effects of gain-of-function (GOF) and loss-of-function (LOF) variants have been predominantly studied on BK...
Novel benzoylurea derivative decreases TRPM7 channel function and inhibits cancer cells migration [0.03%]
新的苯甲酰脲衍生物可降低TRPM7通道功能并抑制癌细胞迁移
Xiaoding Zhang,Rui Zong,Yu Han et al.
Xiaoding Zhang et al.
The transient receptor potential melastatin 7 channel (TRPM7) is a nonselective cation channel highly expressed in some human cancer tissues. TRPM7 is involved in the proliferation, migration, invasion, and epithelial-mesenchymal transition...
The role of mechanosensitive ion channel Piezo1 in knee osteoarthritis inflammation [0.03%]
骨关节炎炎症中机械敏感性离子通道Piezo1的作用机制研究
Dingchang He,Xin Liu,Wenhao Yang et al.
Dingchang He et al.
Mechanosensitive ion channel Piezo1 is known to mediate a variety of inflammatory pathways and is also involved in the occurrence and development of many orthopedic diseases. Although its role in the inflammatory mechanism of knee osteoarth...
Cell size induced bias of current density in hypertrophic cardiomyocytes [0.03%]
肥大心肌细胞中细胞大小引起的电流密度偏差
Elena Lilliu,Benjamin Hackl,Eva Zabrodska et al.
Elena Lilliu et al.
Alterations in ion channel expression and function known as "electrical remodeling" contribute to the development of hypertrophy and to the emergence of arrhythmias and sudden cardiac death. However, comparing current density values - an el...