Molecular mechanisms of function deficiencies in KCNQ1 variants associated with Jervell and Lange-Nielsen syndrome [0.03%]
与Jervell和Lange-Nielsen综合征相关的KCNQ1变异体功能缺陷的分子机制
Xueqi Pan,Yu Xu,Zhenzhen Tan et al.
Xueqi Pan et al.
Jervell and Lange-Nielsen syndrome (JLNS) is characterized by congenital bilateral sensorineural hearing loss, a prolonged QT interval (QTc) on an electrocardiogram (ECG), and a high incidence of sudden death in childhood. More than 90% of ...
Inhibition of lipolysis in visceral adipose tissue from obese mice and humans prevents impairment of endothelial Kir2.1 channels [0.03%]
抑制肥胖小鼠和人类内脏脂肪组织脂解防止内皮Kir2.1通道功能障碍
Emma C Hudgins,Erica J Johnson,Sabita Rokka et al.
Emma C Hudgins et al.
Accumulation of abdominal visceral adipose tissue (VAT) is a major risk factor for cardiovascular disease. Obesity-induced endothelial dysfunction is a precursor to severe disease, and we and others have shown that arteries embedded in VAT,...
Sclareol and cinnarizine are non-selective inhibitors of voltage-gated Cav1.3 L-type Ca2+ channels [0.03%]
氯化棘豆素和赛拉嗪是非选择性阻断电压门控型Cav1.3L型Ca2+通道的抑制剂
Lucia Zanetti,Ferenc Török,Luisa Leitzbach et al.
Lucia Zanetti et al.
A growing body of preclinical evidence indicates that the inhibition of voltage-gated Cav1.3 L-type Ca2+ channels could be a therapeutic concept for the therapy of treatment-resistant hypertension, spinal injury and for neuroprotection in e...
Mechanotransduction mechanisms in human erythrocytes: Fundamental physiology and clinical significance [0.03%]
人红细胞的力学信号转导机制：基础生理和临床意义
Lennart Kuck,Lars Kaestner,Stéphane Egée et al.
Lennart Kuck et al.
The hallmarks of mechanosensitive ion channels have been observed for half a century in various cell lines, although their mechanisms and molecular identities remained unknown until recently. Identification of the bona fide mammalian mechan...
BK channel activity in skin fibroblasts from patients with neurological disorder [0.03%]
神经病患者皮肤纤维母细胞中的BK通道活性
Ria L Dinsdale,Thomas R Middendorf,Deborah Disilvestre et al.
Ria L Dinsdale et al.
Seventy-five unique variants in the KCNMA1 gene have been identified from individuals with neurological disorders. However, variant pathogenicity and evidence for disease causality are lacking in most cases. In this study, the KCNMA1 varian...
Genetic silencing of KCa3.1 inhibits atherosclerosis in ApoE null mice [0.03%]
基因沉默KCa3.1可抑制ApoE敲除小鼠的动脉粥样硬化病变发展
P Alam,D L Tharp,H J Bowles et al.
P Alam et al.
Increased expression of KCa3.1 has been found in vascular smooth muscle cells (SMC), macrophages, and T cells in atherosclerotic lesions from humans and mice. Pharmacological inhibition of KCa3.1 in limiting atherosclerosis has been demonst...
Graded activation of mutant K41C-KCNE1:KCNQ1 channel complexes by mefenamic acid [0.03%]
中药甲灭酸对突变体K41C-KCNE1:KCQN1通道复合体的分级活化作用
Yundi Wang,Magnus Chan,Marc Pourrier et al.
Yundi Wang et al.
The IKs current formed by the co-assembly of KCNE1 and KCNQ1 plays an important role in cardiac repolarization. Mefenamic acid, an NSAID, is known to enhance IKs currents and has in turn been suggested as a therapeutic starting point for th...
The crucial role of potassium ion channels in diabetes mellitus and its complications: A review [0.03%]
钾离子通道在糖尿病及其并发症中的关键作用：综述
Xiangdong Yang,Yan Yang
Xiangdong Yang
Potassium ion channel (K+ channel) is a crucial transmembrane protein found on cell membranes that plays a pivotal role in regulating various physiological processes such as cell membrane potential, action potential formation, and cellular ...
Inwardly rectifying potassium channels: Critical insights for insect species and Apis mellifera [0.03%]
内向整流型钾通道：昆虫纲物种及Apis mellifera的关键见解
Fabien Sourisseau,Craig A Doupnik,Pierre Charnet et al.
Fabien Sourisseau et al.
Kir (inwardly rectifying potassium) channels that play key roles in maintaining potassium homeostasis, neuronal excitability, and osmoregulation have been cloned and characterized in a variety of insects. In Drosophila melanogaster, three K...