Mechanisms linking short- and long-term electrical remodeling in the heart...is it a stretch? [0.03%]
心脏电重构的短期和长期机制之间有何联系……这是过度解读了吗？
Scott B Marrus,Jeanne M Nerbonne
Scott B Marrus
Ion channels play a central role in the normal electro-mechanical functioning of the heart and are implicated in a variety of disease processes. In response to electrical or mechanical perturbations, cardiac myocytes exhibit remarkable chan...
Peptide toxins that selectively target insect Na(V) and Ca(V) channels [0.03%]
选择性靶向昆虫Na(V)和Ca(V)通道的肽类毒素
Glenn F King,Pierre Escoubas,Graham M Nicholson
Glenn F King
Numerous metazoans express venoms for the purpose of defense, competitor deterrence or prey capture. Peptide neurotoxins are particularly well represented in the venoms of arachnids, cnidarians and mollusks and these toxins often possess hi...
Biophysical defects in voltage.gated sodium channels associated with long QT and Brugada syndromes [0.03%]
与长QT综合症和布加氏综合症相关的电压门控钠离子通道生物物理缺陷
David K Jones,Peter C Ruben
David K Jones
The activity of voltage-gated sodium channels contributes to onset and duration of the cardiac action potential through an intricate balance with the activity of other ion channels. Activation of sodium channels leads to membrane depolariza...
Steffen Hering,Stansilav Beyl,Anna Stary et al.
Steffen Hering et al.
Calcium channel family members activate at different membrane potentials, which enables tissue specific calcium entry. Pore mutations affecting this voltage dependence are associated with channelopathies. In this review we analyze the link ...
Petra Eder,Klaus Groschner
Petra Eder
Nonselective and lipid-regulated cation channels formed by TRPC3, TRPC6 and TRPC7 have recently obtained attention in view their potential pathophysiological impact. It appears as a particular challenge to understand the molecular basis of ...
Old proteins, developing roles: The regulation of calcium channels by synaptic proteins [0.03%]
旧蛋白 新角色：突触蛋白对钙通道的调控作用
Jonathan N Davies,Gerald W Zamponi
Jonathan N Davies
Coupling of presynaptic voltage-gated calcium channels to the synaptic release machinery is critical for neurotransmission. It was traditionally believed that anchoring calcium channels close to the calcium microdomain dependent release mac...
Ariela Gordon-Shaag,William N Zagotta,Sharona E Gordon
Ariela Gordon-Shaag
The 30+ members of the family of TRP channels are diverse in their physiological roles, yet the mechanisms that regulate their gating may be conserved. In particular, all TRP channels show an activity-dependent inhibition which is mediated ...
Closed-state inactivation induced in K(V)1 channels by extracellular acidification [0.03%]
细胞外酸化诱导的K(V)1通道封闭失活现象
Thomas W Claydon,Steven J Kehl,David Fedida
Thomas W Claydon
Extracellular acidification regulates the biophysical properties of many voltage-gated potassium channels. Most often acidic pH reduces peak current and enhances current decay during depolarization. Here we review recent data from single ch...
Role of lipid rafts in the interaction between hTRPC1, Orai1 and STIM1 [0.03%]
脂筏在hTRPC1、Orai1和STIM1相互作用中的功能作用
Isaac Jardin,Ginés M Salido,Juan A Rosado
Isaac Jardin
Store-operated Ca2+ entry (SOCE) is a mechanism regulated by the filling state of the intracellular Ca2+ stores that requires the participation of the Ca2+ sensor STIM1, which communicates the Ca2+ content of the stores to the plasma membra...
Anna Stary,Yinon Shafrir,Steffen Hering et al.
Anna Stary et al.
Understanding the structure and functional mechanisms of voltage-gated calcium channels remains a major task in membrane biophysics. In the absence of three dimensional structures, homology modeling techniques are the method of choice, to a...