The importance of cache domains in α2δ proteins and the basis for their gabapentinoid selectivity [0.03%]
α2δ蛋白的缓存域的重要性及其选择性结合加巴喷丁类药物的机制
Karen M Page,Vadim M Gumerov,Shehrazade Dahimene et al.
Karen M Page et al.
In this hybrid review, we have first collected and reviewed available information on the structure and function of the enigmatic cache domains in α2δ proteins. These are organized into two double cache (dCache_1) domains, and they are pre...
Advances in CaV1.1 gating: New insights into permeation and voltage-sensing mechanisms [0.03%]
CaV1.1通道门控的进展：对渗透和电压感应机制的新认识
Hugo Bibollet,Audra Kramer,Roger A Bannister et al.
Hugo Bibollet et al.
The CaV1.1 voltage-gated Ca2+ channel carries L-type Ca2+ current and is the voltage-sensor for excitation-contraction (EC) coupling in skeletal muscle. Significant breakthroughs in the EC coupling field have often been close on the heels o...
John W Hussey,Worawan B Limpitikul,Ivy E Dick
John W Hussey
Calcium ions (Ca2+) are the basis of a unique and potent array of cellular responses. Calmodulin (CaM) is a small but vital protein that is able to rapidly transmit information about changes in Ca2+ concentrations to its regulatory targets....
Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve [0.03%]
呼吸衰竭与迷走神经中NaV1.6抑制的关系研究
Rebecca M Klein,Mark E Layton,Hillary Regan et al.
Rebecca M Klein et al.
As part of a drug discovery effort to identify potent inhibitors of NaV1.7 for the treatment of pain, we observed that inhibitors produced unexpected cardiovascular and respiratory effects in vivo. Specifically, inhibitors administered to r...
Sharon R Stevens,Matthew N Rasband
Sharon R Stevens
The ankyrin proteins (Ankyrin-R, Ankyrin-B, and Ankyrin-G) are a family of scaffolding, or membrane adaptor proteins necessary for the regulation and targeting of several types of ion channels and membrane transporters throughout the body. ...
Plant and fungi derived analgesic natural products targeting voltage-gated sodium and calcium channels [0.03%]
来源于植物和真菌的靶向电压门控钠离子通道和钙离子通道的止痛天然产物
Aida Calderon-Rivera,Santiago Loya-Lopez,Kimberly Gomez et al.
Aida Calderon-Rivera et al.
Voltage-gated sodium and calcium channels (VGSCs and VGCCs) play an important role in the modulation of physiologically relevant processes in excitable cells that range from action potential generation to neurotransmission. Once their expre...
Exploring mutation specific beta blocker pharmacology of the pathogenic late sodium channel current from patient-specific pluripotent stem cell myocytes derived from long QT syndrome mutation carriers [0.03%]
基于利钠肽干细胞心肌细胞的长QT综合征致病性晚钠电流的突变特异性β阻滞剂药理学研究
Thomas W Comollo,Xinle Zou,Chuangeng Zhang et al.
Thomas W Comollo et al.
The congenital long QT syndrome (LQTS), one of the most common cardiac channelopathies, is characterized by delayed ventricular repolarization underlying prolongation of the QT interval of the surface electrocardiogram. LQTS is caused by mu...
Non-conducting functions of ion channels: The case of integrin-ion channel complexes [0.03%]
离子通道的非导电功能：整合素-离子通道复合物的例子
Elena Forzisi,Federico Sesti
Elena Forzisi
Started as an academic curiosity more than two decades ago, the idea that ion channels can regulate cellular processes in ways that do not depend on their conducting properties (non-ionic functions) gained traction and is now a flourishing ...
Piezo1 activation facilitates ovarian cancer metastasis via Hippo/YAP signaling axis [0.03%]
PKP1通过激活Piezo1促进卵巢癌腹膜转移中的机械性痒感效应
Yanjie Xiong,Liru Dong,Yun Bai et al.
Yanjie Xiong et al.
Ovarian cancer (OC) is a highly malignant cancer with great metastatic potential. Here we aimed to investigate the role of Piezo1, a gene related to the mechanical environment of the tumor, in promoting the metastasis of OC. We performed Pi...
Cardiogenic shock due to yew poisoning rescued by VA-ECMO: case report and literature review [0.03%]
毒扁桃子中毒所致心源性休克采用VA-ECMO救治1例及相关文献复习
Nikolaus Schreiber,Martin Manninger,Sascha Pätzold et al.
Nikolaus Schreiber et al.
Ingestion of leaves of the European yew tree (Taxus baccata) can result in fatal cardiac arrhythmias and acute cardiogenic shock. This cardiotoxicity derives from taxine alkaloids that block cardiac voltage-gated sodium and calcium channels...