A robust method to isolate Drosophila fat body nuclei for transcriptomic analysis [0.03%]
用于果蝇脂肪体核分离进行转录组分析的稳健方法
Vanika Gupta,Brian P Lazzaro
Vanika Gupta
Gene expression profiles are typically described at the level of the tissue or, often in Drosophila, at the level of the whole organism. Collapsing the gene expression of entire tissues into single measures averages over potentially importa...
The chemosensory system of the Drosophila larva: an overview of current understanding [0.03%]
果蝇幼虫的化学感觉系统：对现有认识的概述
Nikita Komarov,Simon G Sprecher
Nikita Komarov
Animals must sense their surroundings and be able to distinguish between relevant and irrelevant cues. An enticing area of research aims to uncover the mechanisms by which animals respond to chemical signals that constitute critical sensory...
Spatiotemporal changes in microtubule dynamics during dendritic morphogenesis [0.03%]
树突形态发生过程中微管动态的时空变化
Chun Hu,Pan Feng,Meilan Chen et al.
Chun Hu et al.
Dendritic morphogenesis requires dynamic microtubules (MTs) to form a coordinated cytoskeletal network during development. Dynamic MTs are characterized by their number, polarity and speed of polymerization. Previous studies described a cor...
Mathematical modeling of Notch dynamics in Drosophila neural development [0.03%]
果蝇神经发育中Notch动态的数学建模
Tetsuo Yasugi,Makoto Sato
Tetsuo Yasugi
Notch signalling is a well-conserved signalling pathway that regulates cell fate through cell-cell communication. A typical feature of Notch signalling is 'lateral inhibition', whereby two neighbouring cells of equivalent state of different...
Dawning of the open era [0.03%]
开源时代的来临
Howy Jacobs
Howy Jacobs
Editorial
Fly. 2021 Dec;15(1):89-90. DOI:10.1080/19336934.2021.1943285 2021
In vivo assay and modelling of protein and mitochondrial turnover during aging [0.03%]
蛋白质和线粒体在衰老过程中的体内测定及建模研究
Hans S Bell,John Tower
Hans S Bell
To maintain homoeostasis, cells must degrade damaged or misfolded proteins and synthesize functional replacements. Maintaining a balance between these processes, known as protein turnover, is necessary for stress response and cellular adapt...
Characterizing a gene expression toolkit for eye- and photoreceptor-specific expression in Drosophila [0.03%]
表征一组基因表达工具包以在果蝇中实现眼和光感受器特异性表达
Spencer E Escobedo,Aashka Shah,Alyssa N Easton et al.
Spencer E Escobedo et al.
Binary expression systems are a powerful tool for tissue- and cell-specific research. Many of the currently available Drosophila eye-specific drivers have not been systematically characterized for their expression level and cell-type specif...
Drosophila as a useful model for understanding the evolutionary physiology of obesity resistance and metabolic thrift [0.03%]
果蝇作为理解肥胖抵抗和代谢节俭进化生理的有用模型
Lindsey J Gray,Marla B Sokolowski,Stephen J Simpson
Lindsey J Gray
Evolved metabolic thriftiness in humans is a proposed contributor to the obesity epidemic. Insect models have been shown to evolve both 'metabolic thrift' in response to rearing on high-protein diets that promote leanness, and 'obesity resi...
Flying remote [0.03%]
飞行遥控器
Howy Jacobs
Howy Jacobs
Editorial
Fly. 2021 Dec;15(1):45-46. DOI:10.1080/19336934.2021.1884033 2021
Amel Chaouch,Paul Lasko
Amel Chaouch
Drosophila melanogaster has proven to be a powerful genetic model to study human disease. Approximately 75% of human disease-associated genes have homologs in the fruit fly and regulatory pathways are highly conserved in Drosophila compared...