Systematic generation of Drosophila Wnt transgenes enables the characterization of canonical Wnt signaling [0.03%]
果蝇Wnt转基因的系统产生使得经典Wnt信号通路得以表征
Jamie C Little,Marc Debrunner,Thom de Hoog et al.
Jamie C Little et al.
A conserved cohort of signalling pathways orchestrate development and adult homoeostasis. Deregulation of these pathways underlies many diseases. A key set of signals is the family of Wnt ligands. Members of this family are conserved, but a...
Detection of Nora virus in infected Drosophila melanogaster heads without evidence of ubiquitous brain infection by smRNA FISH [0.03%]
通过smRNA原位杂交技术在感染Nora病毒的果蝇中脑组织中检测不到普遍存在的大脑感染现象
Blase Rokusek,Shalie Sklenar,Luke J Hamilton et al.
Blase Rokusek et al.
Drosophila melanogaster Nora virus (DmNV), a positive-sense single stranded RNA virus related to picornaviruses. Given its genetic and structural similarity to neurotropic picornaviruses, such as poliovirus, we sought to determine whether D...
Loss of Drosophila UBE3A phenocopies Piezo dysfunction and drives hyperphagic feeding in Drosophila [0.03%]
果蝇UBE3A丢失可以模拟Piezo功能丧失并驱动果蝇进食过度现象
Benjamin Geier,Logan Neely,Eli Coronado et al.
Benjamin Geier et al.
Angelman syndrome (AS) is a rare neurogenetic disorder characterized by developmental delay, speech impairment, ataxia, epilepsy, and in some cases hyperphagic feeding behavior. AS is caused by loss of function mutations, loss of expression...
RP gene haploinsufficiency promotes extra sensory organ formation via a threshold effect [0.03%]
半合子不足的RP基因通过剂量阈值效应促进感觉器官异常生长
Haiwei Pi,Kuan-Han Chen,Hsin Tu et al.
Haiwei Pi et al.
Ribosomal protein (RP) gene haploinsufficiency is a conserved form of ribosome dysfunction across species and underlies a class of disorders known as ribosomopathies. In Drosophila, RP gene haploinsufficiency manifests as the Minute phenoty...
Why just fly? [0.03%]
为什么不仅仅是飞行？
Peter K Dearden
Peter K Dearden
Drosophila melanogaster is an incredible model system, providing tools and technologies that allow careful, effective, and reproducible research. This experimental approach, and the genetic tools and techniques available in Drosophila are d...
Innate immunity pathways activate cell proliferation after penetrating traumatic brain injury in adult Drosophila [0.03%]
创伤性脑损伤后成年果蝇的先天免疫途径激活细胞增生
Shawn Ahern-Djamali,Khailee Marischuk,Kassi L Crocker et al.
Shawn Ahern-Djamali et al.
We are utilizing an adult penetrating traumatic brain injury (PTBI) model in Drosophila to investigate regenerative mechanisms after damage to the central brain. Here, we focus on cell proliferation as an early event in the regenerative pro...
UCH-L1 regulates eye differentiation-related genes and modulates EGFR signalling in Drosophila melanogaster [0.03%]
UCH-L1通过调节果蝇眼分化相关基因及模式化EGFR信号转导途径影响眼睛发育
Nguyen Anh Tuan,Tran Linh Thuoc,Dang Thi Phuong Thao
Nguyen Anh Tuan
UCH-L1 (Ubiquitin Carboxyl-terminal Hydrolase - L1) is a protein that plays a critical role in the ubiquitin-proteasome system. Previous studies have demonstrated a link between UCH-L1 and various diseases, including neurodegenerative disor...
What the fruit fly can tell us about autosomal recessive primary microcephaly [0.03%]
果蝇可揭示何种关于常染色体隐性原发性小头症的信息
Shalini Chakraborty,Steven Florez,Todd Schoborg
Shalini Chakraborty
Three decades of research aimed at understanding the basis for autosomal recessive primary microcephaly (MCPH), a human clinical disorder defined by a significant reduction in head and brain size, has uncovered a suite of ~30 genes that par...
Recounting the history of polyploid research in D. melanogaster: 1 century since 2 reports of 3 flies with 4 sets of chromosomes [0.03%]
果蝇(Drosophila melanogaster)多倍体研究的历史回顾——两篇四倍体小飞虫论文百年祭
Lewis I Held
Lewis I Held
One hundred years ago, two reports appeared of tetraploid D. melanogaster females - curiosities that had never been seen before. The authors, Calvin Bridges and Lilian Morgan, were among the famed founders of fly genetics in T.H. Morgan's l...
VacQuant: a tool to quantify neurodegeneration and associated vacuolation in brain tissue [0.03%]
VacQuant：一个量化脑组织神经退行性病变和相关空泡形成的工具
Kate L Jordan,Colin D Veal,Charalambos P Kyriacou et al.
Kate L Jordan et al.
Neurodegenerative diseases are devastating conditions characterized by progressive cognitive decline with few available treatments. Neurodegeneration can be quantified in vertebrate and invertebrate models of disease by analysis of vacuolat...