A Drosophila overexpression screen for modifiers of Rho signalling in cytokinesis [0.03%]
一种调节有丝分裂胞质分离的Rho信号传导修饰因子的果蝇过表达筛选方案
Stephen L Gregory,Tetyana Shandala,Louise O&#x;Keefe et al.
Stephen L Gregory et al.
To identify genes that modulate Rho signalling during cytokinesis we tested the effect of overexpressing a set of 2190 genes on an eye phenotype caused by defective Rho activation. The resulting 112 modifier loci fell into three main classe...
Why clone flies? Using cloned Drosophila to monitor epigenetic defects [0.03%]
为什么克隆果蝇？利用克隆的果蝇监测表观遗传缺陷
Andrew J Haigh,Vett K Lloyd
Andrew J Haigh
Since the birth of the first cloned sheep in 1996, advances in nuclear transplantation have led to both the creation of genetically tailored stem cells and the generation of a number of cloned organisms. The list of cloned animals reared to...
Erin S Kelleher,Therese A Markow
Erin S Kelleher
The process of speciation requires the development of isolating mechanisms that act as barriers to gene flow between incipient species. Such mechanisms can occur at three different levels: precopulatory or behavioral isolation, postcopulato...
Genetic and behavioral analysis of natural variation in Drosophila melanogaster pupation position [0.03%]
果蝇黑色素幼虫化位点的基因和行为分析
Craig A L Riedl,Marit Riedl,Trudy F C Mackay et al.
Craig A L Riedl et al.
Drosophila melanogaster pupae are exposed to many biotic and abiotic dangers while immobilized during several days of metamorphosis. As a passive defense mechanism, appropriate pupation site selection represents an important mitigation of t...
Vector-dependent gene expression driven by insulated P-element reporter vectors [0.03%]
由绝缘P元件报告载体驱动的与元件相关的基因表达
Qianqian Zhu,Marc S Halfon
Qianqian Zhu
The Pelican and Stinger series of P-element transformation vectors are a popular choice for reporter gene expression in transgenic flies. We report here as a cautionary note that these vectors on their own can drive reporter gene expression...
Molecular evolution of Drosophila Cdc6, an essential DNA replication-licensing gene, suggests an adaptive choice of replication origins [0.03%]
果蝇Cdc6的分子进化表明DNA复制起点存在适应性选择
Benjamin L Wiggins,Harmit S Malik
Benjamin L Wiggins
Increased size of eukaryotic genomes necessitated the use of multiple origins of DNA replication, and presumably selected for their efficient spacing to ensure rapid DNA replication. The sequence of these origins remains undetermined in met...
The abdominal-B promoter tethering element mediates promoter-enhancer specificity at the Drosophila bithorax complex [0.03%]
果蝇bithorax复合体中腹盘素B启动子的定位元件介导启动子-增强子的特异性互动
Omar S Akbari,Ben J Schiller,Sara E Goetz et al.
Omar S Akbari et al.
At the Drosophila bithorax complex many distinct classes of cis-regulatory modules work collectively during development to control gene expression. Abdominal-B (Abd-B) is one of three homeotic genes in the BX-C and is expressed in specific ...
Stage-specific modulation of Drosophila gene expression with muscle GAL4 promoters [0.03%]
肌动蛋白GAL4启动子在果蝇特定发育阶段的基因表达调控中的作用
The bipartite GAL4/UAS system is the most widely used method for targeted gene expression in Drosophila melanogaster and facilitates rapid in vivo genetic experimentation. Defining precise gene expression patterns for tissues and/or cell ty...