Accentuate the negative: proteome comparisons using the negative proteome database [0.03%]
强调阴性：使用阴性蛋白质组数据库进行蛋白质组比较
Lawrence T Reiter,Long H Do,Michael S Fischer et al.
Lawrence T Reiter et al.
The availability of complete genome sequence information for diverse organisms including model genetic organisms has ushered in a new era of protein sequence comparisons making it possible to search for commonalities among entire proteomes ...
Comparative Study
Fly. 2007 May-Jun;1(3):164-71. DOI:10.4161/fly.4717 2007
Cathie M Pfleger,Lawrence T Reiter
Cathie M Pfleger
Upon completion of sequencing the Drosophila genome, it was estimated that 61% of human disease-associated genes had sequence homologs in flies, and in some diseases such as cancer, the number was as high as 68%. We now know that as many as...
Climatic adaptations of body melanisation in Drosophila melanogaster from Western Himalayas [0.03%]
喜马拉雅西部地区果蝇(Drosophila melanogaster)体内黑色素化的气候适应性研究
Ravi Parkash,Vineeta Sharma,Bhawna Kalra
Ravi Parkash
We investigated population divergence in body melanisation in wild samples of Drosophila melanogaster across an elevational gradient (512-2202 m) in the Western Himalayas. Wild populations are characterized by higher phenotypic variability ...
Mary-Lou Pardue,P Gregory DeBaryshe
Mary-Lou Pardue
In Drosophila, the role of telomerase is carried out by three specialized retrotransposable elements, HeT-A, TART and TAHRE. Telomeres contain long tandem head-to-tail arrays of these elements. Within each array, the three elements occur in...
Scott L Page,Rachel J Nielsen,Kathy Teeter et al.
Scott L Page et al.
Using an FLP/FRT-based method to create germline clones, we screened Drosophila chromosome arms 2L and 3R for new female meiotic mutants. The screen was designed to recover mutants with severe effects on meiotic exchange and/or segregation....
Kevin Moses
Kevin Moses
On August 1, 2006 the Howard Hughes Medical Institute's first stand-alone research campus opened at Janelia Farm, near Washington DC. Our mission at Janelia is to do exceptional fundamental research. Our two scientific foci are to understan...
An eGFP-based genetic screen for defects in light-triggered subcelluar translocation of the Drosophila photoreceptor channel TRPL [0.03%]
基于EGFP的遗传筛选用于发现调控果蝇视蛋白通道TRPL光触发型亚细胞转移缺陷的相关基因
Nina E Meyer,Claudia Oberegelsbacher,Thomas D Dürr et al.
Nina E Meyer et al.
Signaling at the plasma membrane is modulated by up- and downregulation of signaling proteins. A prominent example for this type of regulation is the Drosophila TRPL ion channel that changes its spatial distribution within the photoreceptor...
Arthur Luhur,Justin P Kumar
Arthur Luhur
Genome and chromosome structure: Twelve dynamic and evolving genomes [0.03%]
基因组和染色体结构：十二种动态的和不断进化的基因组
Vett K Lloyd,Kathleen Fitzpatrick
Vett K Lloyd
Chromosomes are not inert structures that haul the genome through cell division. The dynamic properties of chromosomes, during the cell cycle, the lifetime of the organism and across evolutionary time, featured prominently at the 49(th) Ann...
A genomic response to the yeast transcription factor GAL4 in Drosophila [0.03%]
果蝇的基因组对酵母转录因子GAL4的响应
Yanling Liu,Michael Lehmann
Yanling Liu
The yeast transcription factor GAL4 is widely used in Drosophila genetics to misexpress genes that are under control of the yeast upstream activator sequence (UAS). Here we show that high levels of GAL4 change the expression of many Drosoph...