Rbp4-Gal4, a germline driver that activates in meiosis, reveals functions for VCP in spermatid development [0.03%]
RBp4-Gal4：一种在减数分裂过程中激活的生殖系驱动因子，揭示了VCP在精子发育中的功能
Tyler J Butsch,Alyssa E Johnson,K Adam Bohnert
Tyler J Butsch
Valosin-containing protein (VCP) is a versatile and ubiquitously expressed AAA+ ATPase that regulates multiple stages of Drosophila spermatogenesis. While VCP has documented roles in mitotic spermatogonia and meiotic spermatocytes, it is al...
A tissue dissociation method for ATAC-seq and CUT&RUN in Drosophila pupal tissues [0.03%]
一种用于Drosophila幼虫组织ATAC-seq和CUT&RUN的组织解离方法
Elli M Buchert,Elizabeth A Fogarty,Christopher M Uyehara et al.
Elli M Buchert et al.
Chromatin accessibility, histone modifications, and transcription factor binding are highly dynamic during Drosophila metamorphosis and drive global changes in gene expression as larval tissues differentiate into adult structures. Unfortuna...
The utility and caveat of split-GAL4s in the study of neurodegeneration [0.03%]
分隔GAL4在神经退行性疾病研究中的利与弊
Luca Stickley,Rafael Koch,Emi Nagoshi
Luca Stickley
Parkinson's disease (PD) is the second most common neurodegenerative disorder, afflicting over 1% of the population of age 60 y and above. The loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) is the primary cau...
Downregulation of Plasma Membrane Ca2+ ATPase driven by tyrosine hydroxylase-Gal4 reduces Drosophila lifespan independently of effects in neurons [0.03%]
由酪氨酸羟化酶-Gal4驱动的胞浆膜Ca2+ATP酶下调独立于神经元效应减少果蝇寿命
Brenda Erhardt,Lia Frenkel,María Silvina Marcora et al.
Brenda Erhardt et al.
In Drosophila melanogaster, several Gal4 drivers are used to direct gene/RNAi expression to different dopaminergic neuronal clusters. We previously developed a fly model of Parkinson's disease, in which dopaminergic neurons had elevated cyt...
Ryusuke Niwa,Makoto Sato,Tatsushi Igaki
Ryusuke Niwa
You may say I'm a dreamer [0.03%]
你可以称我为梦想家
Howy Jacobs
Howy Jacobs
Iryna Kozeretska
Iryna Kozeretska
Larval nutritional-stress and tolerance to extreme temperatures in the peach fruit fly, Bactrocera zonata (Diptera: Tephritidae) [0.03%]
桃实蝇幼虫的营养压力及对极端温度的耐受性研究
M Ben-Yosef,Y Altman,E Nemni-Lavi et al.
M Ben-Yosef et al.
Within the factors affecting insect tolerance to extreme environmental conditions, insect nutrition, particularly of immature stages, has received insufficient attention. In the present study, we address this gap by investigating the effect...
Masato Enomoto,Tatsushi Igaki
Masato Enomoto
Cell-cell interactions within tumour microenvironment play crucial roles in tumorigenesis. Genetic mosaic techniques available in Drosophila have provided a powerful platform to study the basic principles of tumour growth and progression vi...
A screen of small molecule and genetic modulators of life span in female Drosophila identifies etomoxir, RH5849 and unanticipated temperature effects [0.03%]
果蝇雌性小分子和基因寿命调节因子的筛选确定了乙莫克司，RH5849 和意外的温度影响
Gary N Landis,Sebastian Ko,Oscar Peng et al.
Gary N Landis et al.
Mifepristone increases life span in female Drosophila melanogaster, and its molecular target(s) remain unclear. Here small molecule and genetic interventions were tested for ability to mimic mifepristone, or to decrease life span in a way t...