Optimization of hybridization chain reaction for imaging single RNA molecules in Drosophila larvae [0.03%]
优化杂交链反应以在果蝇幼虫中对单个RNA分子进行成像
Julia Olivares-Abril,Jana Joha,Jeffrey Y Lee et al.
Julia Olivares-Abril et al.
In situ hybridization techniques are powerful methods for exploring gene expression in a wide range of biological contexts, providing spatial information that is most often lost in traditional biochemical techniques. However, many in situ h...
An unusual Toll/MyD88-mediated Drosophila host defence against Talaromyces marneffei [0.03%]
一个不寻常的果蝇Toll/MyD88介导的防御机制对抗马尔尼菲青霉菌感染
Xiaoyue Wang,Qinglin Qu,Zi Li et al.
Xiaoyue Wang et al.
Talaromycosis, caused by Talaromyces marneffei (T. marneffei, formerly known as Penicillium marneffei), is an opportunistic invasive mycosis endemic in tropical and subtropical areas of Asia with high mortality rate. Despite various infecti...
Conserved A-to-I RNA editing with non-conserved recoding expands the candidates of functional editing sites [0.03%]
保守的A到I RNA编辑与非保守的重编码扩展了功能编辑位点候选对象
Yuange Duan,Ling Ma,Tianyou Zhao et al.
Yuange Duan et al.
Adenosine-to-inosine (A-to-I) RNA editing recodes the genome and confers flexibility for the organisms to adapt to the environment. It is believed that RNA recoding sites are well suited for facilitating adaptive evolution by increasing the...
The astrocyte-enriched gene deathstar plays a crucial role in the development, locomotion, and lifespan of D. melanogaster [0.03%]
星形胶质细胞富集基因deathstar在果蝇发育、运动和寿命中发挥重要作用
Xiaoli Zhang,Dongyu Sun,Kyle Wong et al.
Xiaoli Zhang et al.
The Drosophila melanogaster brain is a complex organ with various cell types, orchestrating the development, physiology, and behaviors of the fly. While each cell type in Drosophila brain is known to express a unique gene set, their complet...
Nicole A Losurdo,Adriana Bibo,Jacob Bedke et al.
Nicole A Losurdo et al.
To identify genes required for brain growth, we took an RNAi knockdown reverse genetic approach in Drosophila. One potential candidate isolated from this effort is the anti-lipogenic gene adipose (adp). Adp has an established role in the ne...
Effects of unstable β-PheRS on food avoidance, growth, and development are suppressed by the appetite hormone CCHa2 [0.03%]
不稳定的β-苯丙氨酸-tRNA合成酶对食物回避、生长和发育的影响被食欲激素CCHa2抑制
Dominique Brunßen,Beat Suter
Dominique Brunßen
Amino acyl-tRNA synthetases perform diverse non-canonical functions aside from their essential role in charging tRNAs with their cognate amino acid. The phenylalanyl-tRNA synthetase (PheRS/FARS) is an α2β2 tetramer that is needed for char...
Ribose-cysteine and levodopa abrogate Parkinsonism via the regulation of neurochemical and redox activities in alpha-synuclein transgenic Drosophila melanogaster models [0.03%]
核糖-半胱氨酸和左旋多巴通过调控α-突触核蛋白转基因果蝇模型的神经化学及抗氧化活性缓解帕金森症状
Olumayowa K Idowu,Ademola A Oremosu,Olufunke O Dosumu et al.
Olumayowa K Idowu et al.
Parkinson's disease (PD), the most prevalent type of parkinsonism, is a progressive neurodegenerative condition marked by several non-motor and motor symptoms. PD is thought to have a complex aetiology that includes a combination of age, ge...
Long-range repression by ecdysone receptor on complex enhancers of the insulin receptor gene [0.03%]
泛素连接酶CHIP介导的ATF4降解在内质网应激中的作用
Katie D Thompson,Will Suber,Rachel Nicholas et al.
Katie D Thompson et al.
The insulin signalling pathway is evolutionarily conserved throughout metazoans, playing key roles in development, growth, and metabolism. Misregulation of this pathway is associated with a multitude of disease states including diabetes, ca...
First record of Stigmatomyces (Ascomycota: Laboulbeniales) on Drosophilidae from Japan [0.03%]
日本Drosophilidae首次记录到Laboulbeniales的Stigmatomyces属标本
Izumi Yamazaki,Moe Onuma,Haruka Omiya et al.
Izumi Yamazaki et al.
Three Stigmatomyces species were detected on five drosophilid species from Japan. We report Stigmatomyces majewskii on Drosophila rufa and Drosophila suzukii, Stigmatomyces scaptodrosophilae on Scaptodrosophila coracina and Scaptodrosophila...
Rbp4-Gal4, a germline driver that activates in meiosis, reveals functions for VCP in spermatid development [0.03%]
RBp4-Gal4：一种在减数分裂过程中激活的生殖系驱动因子，揭示了VCP在精子发育中的功能
Tyler J Butsch,Alyssa E Johnson,K Adam Bohnert
Tyler J Butsch
Valosin-containing protein (VCP) is a versatile and ubiquitously expressed AAA+ ATPase that regulates multiple stages of Drosophila spermatogenesis. While VCP has documented roles in mitotic spermatogonia and meiotic spermatocytes, it is al...