Expanding the Iroquois genes repertoire: a non-transcriptional function in cell cycle progression [0.03%]
扩大Iroquois基因的基因组：细胞周期进程中的非转录功能
Natalia Barrios,Sonsoles Campuzano
Natalia Barrios
Drosophila Iroquois (Iro) proteins are components of the TALE homeodomain family of transcriptional regulators. They play key roles in territorial specification and pattern formation. A recent study has disclosed a novel developmental funct...
Functions of the SLC36 transporter Pathetic in growth control [0.03%]
SLC36家族成员Pathetic调控拟南芥生长的分子机制研究
Wen-Yang Lin,Claire R Williams,Connie Yan et al.
Wen-Yang Lin et al.
Neurons exhibit extreme diversity in size, but whether large neurons have specialized mechanisms to support their growth is largely unknown. Recently, we identified the SLC36 transporter Pathetic (Path) as a factor required for extreme dend...
Frank W Avila,Alex Wong,Jessica L Sitnik et al.
Frank W Avila et al.
Mating plugs are hardened structures--typically a coagulation of seminal fluid components--that are transferred to, or formed within, the female reproductive tract of numerous animal species (both mammals and insects). Analysis of the role(...
Non-cell autonomous cell death caused by transmission of Huntingtin aggregates in Drosophila [0.03%]
线虫中亨廷顿蛋白聚集体的传播诱发非细胞自主性细胞死亡
Daniel T Babcock,Barry Ganetzky
Daniel T Babcock
Recent evidence indicates that protein aggregates can spread between neurons in several neurodegenerative diseases but much remains unknown regarding the underlying mechanisms responsible for this spreading and its role in disease progressi...
Chenhui Wang,Rongwen Xi
Chenhui Wang
Intestinal epithelium in adult Drosophila midgut undergoes regular turnover and renewal. This process is fueled by intestinal stem cells (ISCs), which can self-renew as well as produce both absorptive enterocytes (ECs) and secretory enteroe...
Kyung-Ah Lee,Boram Kim,Hyejin You et al.
Kyung-Ah Lee et al.
Intestinal dual oxidase (DUOX) activation is the first line of host defense against enteric infection in Drosophila. DUOX enzymatic activity is mainly controlled by phospholipase C-β (PLCβ)-dependent calcium mobilization, whereas DUOX gen...
Tudor-domain containing proteins act to make the piRNA pathways more robust in Drosophila [0.03%]
tudor结构域蛋白使果蝇piRNA信号通路更加稳定可靠
Kaoru Sato,Yuka W Iwasaki,Haruhiko Siomi et al.
Kaoru Sato et al.
PIWI-interacting RNAs (piRNAs), a subset of small non-coding RNAs enriched in animal gonads, repress transposons by assembling with PIWI proteins to form potent gene-silencing RNP complexes, piRISCs. Accumulating evidence suggests that piRN...
Andrea Chai,Giuseppa Pennetta
Andrea Chai
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease causing the death of motor neurons with consequent muscle atrophy and paralysis. Several neurodegenerative diseases have been modeled in Drosophila and genetic s...
Elly Ordan,Talila Volk
Elly Ordan
The formation of functional musculoskeletal system relies on proper connectivity between muscles and their corresponding tendon cells. In Drosophila, larval muscles are born during early embryonic stages, and elongate toward tendons that ar...
Genetic basis of natural variation in body pigmentation in Drosophila melanogaster [0.03%]
果蝇体色自然变异的遗传基础
Lauren M Dembeck,Wen Huang,Mary Anna Carbone et al.
Lauren M Dembeck et al.
Body pigmentation in insects and other organisms is typically variable within and between species and is often associated with fitness. Regulatory variants with large effects at bab1, t and e affect variation in abdominal pigmentation in se...