Compromising asymmetric stem cell division in Drosophila central brain: Revisiting the connections with tumorigenesis [0.03%]
果蝇中枢脑干细胞的不对称分裂偏向性及其与肿瘤的关系探究
Ana Carmena
Ana Carmena
Asymmetric cell division (ACD) is an essential process during development for generating cell diversity. In addition, a more recent connection between ACD, cancer and stem cell biology has opened novel and highly intriguing venues in the fi...
FijiWingsPolarity: An open source toolkit for semi-automated detection of cell polarity [0.03%]
斐济翼极性：一个用于半自动检测细胞极性的开源工具包
Leonard L Dobens,Anna Shipman,Jeffrey D Axelrod
Leonard L Dobens
Epithelial cells are defined by apical-basal and planar cell polarity (PCP) signaling, the latter of which establishes an orthogonal plane of polarity in the epithelial sheet. PCP signaling is required for normal cell migration, differentia...
Identifying the minimum number of microsatellite loci needed to assess population genetic structure: A case study in fly culturing [0.03%]
通过果蝇培养例证分析鉴定用于评估种群遗传结构的最少微卫星基因座数量的方法
Wolfgang Arthofer,Carina Heussler,Patrick Krapf et al.
Wolfgang Arthofer et al.
Small, isolated populations are constantly threatened by loss of genetic diversity due to drift. Such situations are found, for instance, in laboratory culturing. In guarding against diversity loss, monitoring of potential changes in popula...
Pleiotropy in Drosophila organogenesis: Mechanistic insights from Combgap and the retinal determination gene network [0.03%]
果蝇器官发生中的多效性：Combgap及视盘决定基因网络的机制研究
Trevor L Davis,Ilaria Rebay
Trevor L Davis
Master regulatory transcription factors cooperate in networks to shepherd cells through organogenesis. In the Drosophila eye, a collection of master control proteins known as the retinal determination gene network (RDGN) switches the direct...
Extending julius seizure, a bang-sensitive gene, as a model for studying epileptogenesis: Cold shock, and a new insertional mutation [0.03%]
利用一种易爆敏感基因癫痫发作扩展研究癫痫发生的新模型：寒冷休克及新的插入突变体
Derek Dean,Hannah Weinstein,Seema Amin et al.
Derek Dean et al.
The bang-sensitive (BS) mutants of Drosophila are an important model for studying epilepsy. We recently identified a novel BS locus, julius seizure (jus), encoding a protein containing two transmembrane domains and an extracellular cysteine...
Strong responses of Drosophila melanogaster microbiota to developmental temperature [0.03%]
发育温度对果蝇拟步甲肠道微生物的影响强烈
Neda N Moghadam,Pia Mai Thorshauge,Torsten N Kristensen et al.
Neda N Moghadam et al.
Physiological responses to changes in environmental conditions such as temperature may partly arise from the resident microbial community that integrates a wide range of bio-physiological aspects of the host. In the present study, we assess...
Deletion of the nicotinic acetylcholine receptor subunit gene Dα1 confers insecticide resistance, but at what cost? [0.03%]
删除尼古丁乙酰胆碱受体亚基基因Dα1能赋予昆虫抗药性，但有何代价？
Jason Somers,Hang Ngoc Bao Luong,Philip Batterham et al.
Jason Somers et al.
Nicotinic acetylcholine receptors (nAChRs) have vital functions in processes of neurotransmission that underpin key behaviors. These pentameric ligand-gated ion channels have been used as targets for insecticides that constitutively activat...
Control of protein translation by IP3R-mediated Ca2+ release in Drosophila neuroendocrine cells [0.03%]
Drosophila神经内分泌细胞中由IP3R介导的Ca2+释放对蛋白质翻译的调控作用
Megha,Gaiti Hasan
Megha
The inositol 1,4,5-trisphosphate receptor (IP3R) is one of two Ca2+ channels that gates Ca2+ release from ER-stores. The ligand IP3, generated upon specific G-protein coupled receptor activation, binds to IP3R to release Ca2+ into the cytos...
Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewal [0.03%]
BMP信号在调节果蝇肠道干细胞自我更新中的双重作用
Aiguo Tian,Jin Jiang
Aiguo Tian
Many adult organs including Drosophila adult midguts rely on resident stem cells to replenish damaged cells during tissue homeostasis and regeneration. Previous studies have shown that, upon injury, intestinal stem cells (ISCs) in the midgu...
Alexandra Franz,Erich Brunner,Konrad Basler
Alexandra Franz
The ease of generating genetically modified animals and cell lines has been markedly increased by the recent development of the versatile CRISPR/Cas9 tool. However, while the isolation of isogenic cell populations is usually straightforward...