Why just fly? [0.03%]
为什么不仅仅是飞行？
Peter K Dearden
Peter K Dearden
Drosophila melanogaster is an incredible model system, providing tools and technologies that allow careful, effective, and reproducible research. This experimental approach, and the genetic tools and techniques available in Drosophila are d...
Innate immunity pathways activate cell proliferation after penetrating traumatic brain injury in adult Drosophila [0.03%]
创伤性脑损伤后成年果蝇的先天免疫途径激活细胞增生
Shawn Ahern-Djamali,Khailee Marischuk,Kassi L Crocker et al.
Shawn Ahern-Djamali et al.
We are utilizing an adult penetrating traumatic brain injury (PTBI) model in Drosophila to investigate regenerative mechanisms after damage to the central brain. Here, we focus on cell proliferation as an early event in the regenerative pro...
UCH-L1 regulates eye differentiation-related genes and modulates EGFR signalling in Drosophila melanogaster [0.03%]
UCH-L1通过调节果蝇眼分化相关基因及模式化EGFR信号转导途径影响眼睛发育
Nguyen Anh Tuan,Tran Linh Thuoc,Dang Thi Phuong Thao
Nguyen Anh Tuan
UCH-L1 (Ubiquitin Carboxyl-terminal Hydrolase - L1) is a protein that plays a critical role in the ubiquitin-proteasome system. Previous studies have demonstrated a link between UCH-L1 and various diseases, including neurodegenerative disor...
What the fruit fly can tell us about autosomal recessive primary microcephaly [0.03%]
果蝇可揭示何种关于常染色体隐性原发性小头症的信息
Shalini Chakraborty,Steven Florez,Todd Schoborg
Shalini Chakraborty
Three decades of research aimed at understanding the basis for autosomal recessive primary microcephaly (MCPH), a human clinical disorder defined by a significant reduction in head and brain size, has uncovered a suite of ~30 genes that par...
Recounting the history of polyploid research in D. melanogaster: 1 century since 2 reports of 3 flies with 4 sets of chromosomes [0.03%]
果蝇(Drosophila melanogaster)多倍体研究的历史回顾——两篇四倍体小飞虫论文百年祭
Lewis I Held
Lewis I Held
One hundred years ago, two reports appeared of tetraploid D. melanogaster females - curiosities that had never been seen before. The authors, Calvin Bridges and Lilian Morgan, were among the famed founders of fly genetics in T.H. Morgan's l...
VacQuant: a tool to quantify neurodegeneration and associated vacuolation in brain tissue [0.03%]
VacQuant：一个量化脑组织神经退行性病变和相关空泡形成的工具
Kate L Jordan,Colin D Veal,Charalambos P Kyriacou et al.
Kate L Jordan et al.
Neurodegenerative diseases are devastating conditions characterized by progressive cognitive decline with few available treatments. Neurodegeneration can be quantified in vertebrate and invertebrate models of disease by analysis of vacuolat...
Electrical silencing of dendritic arborization neurons rescues toxic polyglutamine-induced locomotion defect [0.03%]
通过电沉默树突状神经元来修复有毒聚谷氨酰胺引起的运动缺陷
Hongyu Miao,Woo Jae Kim
Hongyu Miao
This study investigates the effects of polyglutamine (polyQ) expansions on the locomotion of Drosophila larvae, focusing on the role of class IV dendritic arborization (da) neurons. PolyQ expansions are associated with neurodegenerative dis...
Open carry [0.03%]
公开携枪
Howy Jacobs
Howy Jacobs
Experimental assessment of 3D-printed traps and chemical attractants for the collection of wild Drosophila melanogaster [0.03%]
实验评估用于收集野生黑腹果蝇的3D打印陷阱和化学引诱剂的效果
Alexandra H Keene-Snickers,Tillie J Dunham,Mark D Stenglein
Alexandra H Keene-Snickers
Drosophila melanogaster, the common fruit fly, has been instrumental to our understanding of evolution, genetics and disease. There are benefits to studying these flies in the wild, including assessment of their naturally occurring microbio...
Orie Thomas Shafer
Orie Thomas Shafer
The field of Drosophila sleep research, which began 25 years ago, has identified more than 200 genes influencing sleep. In this review, I summarize the foundation of the field and the growing list of genes implicated in sleep regulation. I ...