POU2F2 as a dual oncogenic and immunomodulatory driver in kidney renal clear cell carcinoma [0.03%]
POU2F2在肾透明细胞癌中的双重致癌和免疫调节驱动作用
Gonglin Tang,Fei Liu,Mingze Sun et al.
Gonglin Tang et al.
Kidney renal clear cell carcinoma (KIRC) features an immunosuppressive tumor microenvironment (TME). We investigated the role of transcription factor POU2F2 in KIRC oncogenesis and macrophage polarization. Single-cell and spatial transcript...
Abnormal expression of galectins and their correlation with fibrogenesis in adenomyosis [0.03%]
腺肌症中半乳糖凝集素的异常表达及其与纤维化的相关性研究
Yuan Zhou,Mengdong Cao,Zhenzhen Wang et al.
Yuan Zhou et al.
This cross-sectional study investigated galectin-1, -3, and -9 in adenomyosis. Analysis of hysterectomy tissues from premenopausal women via western blot, qPCR, immunohistochemistry, and Masson's staining revealed significantly elevated gal...
RBM15B-mediated m6A modification of FOXM1 activates the AURKA/TPX2 axis to promote epithelial-mesenchymal transition-driven endometrial cancer progression [0.03%]
RBM15B介导的FOXM1 mRNA m6A修饰激活AURKA/TPX2轴以促进子宫内膜癌上皮间质转化的发展
Lijing Zhang,Ping Wu
Lijing Zhang
Endometrial cancer(EC) is increasing worldwide, but its molecular mechanisms remain unclear. This study explored whether RBM15B-mediated m6A modification of FOXM1 promotes EC progression through the AURKA/TPX2 axis and epithelial-mesenchyma...
Dynamic modulation of intercellular adhesion mediated by matriptase-EPCAM/Trop-2 axes is critical for cell extrusion, division, and collective migration [0.03%]
由matriptase-EPCAM/Trop-2轴介导的细胞间黏附的动态调节对于细胞排出、分裂和集体迁移至关重要
Yu-Ling A Kao,Qiaochu Wang,Dajun D Lu et al.
Yu-Ling A Kao et al.
Epithelial dynamics require rapid remodeling of cell adhesion during extrusion, division, and migration. We identify a matriptase-dependent mechanism regulating the Ca2+- independent adhesion molecules EpCAM and Trop-2. Matriptase activatio...
CXCL11 secreted by cancer-associated fibroblasts promotes nasopharyngeal carcinoma progression via CXCR3/PD-L1 axis [0.03%]
癌相关成纤维细胞分泌的CXCL11通过CXCR3/PD-L1轴促进鼻咽癌进展
Jie Fang,Huijuan Cheng,Peng Zhang et al.
Jie Fang et al.
The secretion of chemokines by cancer-associated fibroblasts (CAFs) is a critical driver of cancer progression. Nevertheless, the precise contribution of CAFs in the nasopharyngeal carcinoma (NPC) tumor microenvironment to disease progressi...
Meox1 promotes hepatocellular carcinoma progression potentially via regulation of cell cycle and p21 expression [0.03%]
Meox1通过调节细胞周期和p21表达促进肝癌进展
Jie Ruan,Ying Xie,Chaoqun Zhang et al.
Jie Ruan et al.
Meox1 is aberrantly expressed in several malignancies, but its role in hepatocellular carcinoma (HCC) remains unclear. This study aimed to investigate the effects of Meox1 on HCC cells and explore the underlying molecular mechanisms. Cell p...
STED/AFM as a tool to investigate mechanical and adhesive properties of migrating keratinocytes [0.03%]
用于探究迁移角质细胞力学和粘附性质的STED/AFM技术
Mariya Y Radeva,Jens Waschke,Michael Fuchs
Mariya Y Radeva
E-cadherin is a key component of adherens junctions which maintains epithelial integrity. In keratinocytes, wound healing requires dynamic modulation of adhesion and cytoskeletal organization. Using a wound healing assay combined with stimu...
TNS1 and TNS4 play a potential role in development of pancreatic ductal adenocarcinoma but not TNS2 and TNS3 [0.03%]
TNS1和TNS4在胰腺导管腺癌发生发展中可能发挥重要作用但TNS2和TNS3却不起作用
Natalia Świsłocka,Anna Pryczynicz,Justyna Dorf et al.
Natalia Świsłocka et al.
Tensins are a family of adhesion proteins that play a role in constructing the cytoskeleton, as well as in intracellular and extracellular communication. Their expression was evaluated in 22 pancreatic cancer patients using the immunohistoc...
N6-methyladenosine modification of NEU1 mediated by METTL3 exacerbates angiotensin II-induced atrial fibrillation [0.03%]
METTL3介导的NEU1m6A修饰加重血管紧张素II诱导的房颤
Zhilan Zhang,Yanbing Luo,Qiuguo Zou et al.
Zhilan Zhang et al.
Neuraminidase 1 (NEU1) regulation of atrial fibrillation (AF) progression via fibrosis remains unknown. Mice receiving AAV9-mediated NEU1 knockdown were infused with Ang II and subjected to programmed electrical stimulation to induce AF. Le...
LncRNA UNC5C-AS1 inhibits angiogenesis and induces endothelial apoptosis via the miR-148a-3p/EMP1 axis in preeclampsia [0.03%]
长链非编码RNA UNC5C-AS1通过miR-148a-3p/EMP1轴抑制子痫前期血管生成并诱导内皮细胞凋亡
Yang Wang,Yan Gao,Lingfang Liu et al.
Yang Wang et al.
Preeclampsia (PE) is a severe pregnancy complication with unclear molecular mechanisms. Our research investigated the effect of UNC5C-AS1 on human umbilical vein endothelial cell (HUVEC) function in PE. UNC5C-AS1 was downregulated in PE pla...