LncRNA UNC5C-AS1 inhibits angiogenesis and induces endothelial apoptosis via the miR-148a-3p/EMP1 axis in preeclampsia [0.03%]
长链非编码RNA UNC5C-AS1通过miR-148a-3p/EMP1轴抑制子痫前期血管生成并诱导内皮细胞凋亡
Yang Wang,Yan Gao,Lingfang Liu et al.
Yang Wang et al.
Preeclampsia (PE) is a severe pregnancy complication with unclear molecular mechanisms. Our research investigated the effect of UNC5C-AS1 on human umbilical vein endothelial cell (HUVEC) function in PE. UNC5C-AS1 was downregulated in PE pla...
EPB41L family serves as a prognostic biomarker for kidney renal clear cell carcinoma [0.03%]
EPB41L家族作为肾脏透明细胞癌预后生物标志物的作用
Gonglin Tang,Kai Sun,Guixin Ding et al.
Gonglin Tang et al.
EPB41L1-5 is known to maintain cell morphology and signal transduction, with evidence suggesting it can inhibit tumor progression. However, its role in kidney renal clear cell carcinoma (KIRC) is not fully understood. This study evaluated E...
Research on tissue-resident macrophages in the field of cancer research: a bibliometric analysis from 2004 to 2025 [0.03%]
2004-2025年肿瘤相关驻留巨噬细胞研究的文献计量分析
Qingya Song,Zongliang Yu,Wenping Lu et al.
Qingya Song et al.
In the tumor microenvironment, tissue-resident macrophages (TRMs) promote malignant tumor progression, yet their tissue-specific heterogeneity and complex functions bring research challenges. This study analyzes the research status and tren...
COPB2 drives gastric cancer progression via PI3K/AKT/NF-κB signaling: a multi-omics and functional study [0.03%]
COPB2通过PI3K/AKT/NF-κB信号促进胃癌进展：一项多组学和功能研究
Hailong Li,Dong Wei,Xiaqing Gao et al.
Hailong Li et al.
This study investigated the role of COPB2 in gastric cancer (GC) pathogenesis. Analysis of TCGA datasets and tissue microarrays revealed its upregulation in GC tissues compared to normal adjacent tissues, which was correlated with advanced ...
NCEH1 promotes breast cancer progression by regulating NRP1 and activating the TNF-α/NF-κB signalling pathway [0.03%]
NCEH1通过调节NRP1和激活TNF-α/NF-κB信号通路促进乳腺癌进展
Jie Sun,Yaqian Liu,Jieji Mo et al.
Jie Sun et al.
Purpose: Neutral cholesterol ester hydrolase 1 (NCEH1), a key enzyme in cellular lipid metabolism, is associated with cancer progression. Its molecular functions in breast cancer remain poorly understood. ...
Upregulation of LTF promotes left-sided colorectal cancer development via activating PI3K/AKT pathway [0.03%]
LTF上调通过激活PI3K/AKT信号促进左侧结直肠癌发生发展
Peng Chen,Mingrui Zhang,Xuefeng Bai
Peng Chen
Lactoferrin (LTF) has gained attention as a potential anti-cancer biomarker, but its role in left-sided colon cancer (LCC) remains poorly understood. This study explores the function of LTF in LCC and its underlying mechanisms. LTF expressi...
Telomerase inhibitors - TMPyP4, BIBR 1532 and imetelstat - alter the adhesion potential of breast cancer MCF7 and MDA-MB-231 cells that leads to impaired ability to form spheroids [0.03%]
端粒酶抑制剂TMPyP4、BIBR 1532 和伊美替尼可改变乳腺癌MCF7和MDA-MB-231细胞的黏附能力并使其难以形成类器官球体
Przemysław Kopczyński,Aleksandra Romaniuk-Drapała,Kinga Rygiel et al.
Przemysław Kopczyński et al.
We assessed the influence of telomerase inhibitors TMPyP4, BIBR 1532, or imetelstat on the ability of MCF7 and MDA-MB-231 breast cancer cells to form spheroids. TMPyP4 significantly impaired the adhesion potential and ability of both cell l...
Super-resolution microscopy reveals glioma cell footprints and exosome deposits [0.03%]
超分辨率显微镜揭示了胶质瘤细胞足迹和外泌体沉积物
Stefania Petrini,Frédéric Eghiaian,Valentina Apollonio et al.
Stefania Petrini et al.
Gliomas are aggressive brain tumors whose infiltrative growth is mediated by intercellular crosstalk. Exosomes, small extracellular vesicles, play a key role in cell-cell communication but are difficult to visualize using conventional micro...
Pathological significance and therapeutic prospects of HCCS expression patterns in lung adenocarcinoma [0.03%]
HCCS表达模式在肺腺癌中的病理意义及治疗前景研究
Pengfei Luo,Sixuan Wu,Zhimin Li et al.
Pengfei Luo et al.
This study examines Holocytochrome c synthase (HCCS) expression in lung adenocarcinoma (LUAD) and its impact on the tumor immune environment. By analyzing multiple tumor databases, the research highlights HCCS expression patterns across var...
MiR-646 inhibited cell proliferation and migration by targeting P62 in glioma [0.03%]
microRNA-646通过靶向P62抑制胶质瘤的细胞增殖和迁移
Fangyu Ye,Heng Zhang,Qianqian Chen et al.
Fangyu Ye et al.
MiR-646, a small non-coding RNA, poorly expressed in a variety of tumors. This study aimed to clarify the role of miR-646 and its underlying mechanisms in glioblastoma (GBM). In our study, we found that miR-646 mRNA levels were lower in tum...