Maternal chronic wasting disease infection restricts fetal head size in white-tailed deer (Odocoileus virginianus) [0.03%]
母性慢性消耗病感染限制了白尾鹿（Odocoileus virginianus）胎儿头部大小
Jameson Mori,Sara Villazan Perez-Girones,Tooba Latif et al.
Jameson Mori et al.
Chronic wasting disease (CWD) is a fatal neurodegenerative prion disease of cervids that can be transmitted through direct physical contact, indirect contact with a contaminated environment, or vertical transmission. CWD is characterized by...
Plaque-type dura mater graft-associated Creutzfeldt-Jakob disease: an autopsied case report [0.03%]
与硬脑膜有关的亚急性进行性痴呆1例及其组织病理和免疫组化研究
Daisuke Tahara,Daichi Yokoi,Nao Tahara et al.
Daisuke Tahara et al.
Clinicopathologically, dura mater graft-associated Creutzfeldt-Jakob disease (dCJD) presents as either a non-plaque or plaque type. Here, we report an autopsy case of plaque-type dCJD, supported by genetic and biochemical analyses. A 41-yea...
Case Reports
Prion. 2026 Dec;20(1):31-40. DOI:10.1080/19336896.2026.2635298 2026
Efficient induction of motor neuron disease in transgenic G93A SOD1 mice by prion-like seeding [0.03%]
朊病毒样种子高效诱导转基因G93A SOD1小鼠运动神经元疾病
Guilian Xu,Amanda Lopez,Selma Brkic et al.
Guilian Xu et al.
Mutations in superoxide dismutase 1 (SOD1) cause paralysis in familial amyotrophic lateral sclerosis and promote its misfolding into neurotoxic aggregates. Previous studies have shown that mice expressing the ALS-causing G85R variant of SOD...
Prion 2025: advancing the understanding and treatment of prion diseases in dialogue with patients and families [0.03%]
朊蛋白2025：通过与患者及其家属对话增进对朊粒疾病的研究和治疗理解
Tuane C R G Vieira,Jerson Lima Silva
Tuane C R G Vieira
Prion 2025, held in Armação dos Búzios, Brazil (3-7 November 2025), was the first PRION congress in Latin America and brought together 260 participants from 22 countries. Building on the broadening scope of recent meetings, this edition ...
Prion seeding activity in DNA extractions: implications for laboratory biosafety [0.03%]
DNA提取物中的朊病毒种子活性：对实验室生物安全的意义
Sarah C Gresch,Tamara Morrill,Maddy Ellis-Cramer et al.
Sarah C Gresch et al.
Infectious prions (PrPSc) are largely resistant to proteolytic digestion, including proteinase K (PK) digestion. While nucleic acid extracts are generally considered non-infectious from a classical microbiology context (i.e. free of intact ...
Development of a user guide to support administration of the MRC Prion Disease Rating Scale in research and clinical settings for prion diseases [0.03%]
一种用户指南的开发以支持MRC朊病毒疾病评分量表在研究和临床环境中用于朊病毒疾病的管理
Robert S Pulido,Chris Marshall,Anne V Smith et al.
Robert S Pulido et al.
Background: The prion diseases (PrD) are a group of progressive, fatal, neurodegenerative diseases, for which the Medical Research Council Prion Disease Rating Scale (MRC Scale) can be used to assess patients' functional ...
Differential pathology of P102L-associated Gerstmann-Stäussler-Scheinker disease: exclusive presence of 8-kDa protease-resistant prion protein vs. co-existence of 8-kDa and type-1 protease-resistant prion protein, with a focus on codon 129 polymorphism [0.03%]
P102L相关的Gerstmann-Stäussler-Scheinker病的病理学差异：仅存在8kDa蛋白酶抗性PrP与同时存在8kDa和1型蛋白酶抗性PrP，重点关注密码子129多态性
Hideko Noguchi,Motoi Yoshimura,Akihiro Watanabe et al.
Hideko Noguchi et al.
Gerstmann - Sträussler - Scheinker disease (GSS) is a hereditary prion disease characterized by clinicopathological heterogeneity. In Japan, the most common mutation is P102L, typically associated with prion protein (PrP) plaques, spongifo...
Case Reports
Prion. 2025 Dec;19(1):50-66. DOI:10.1080/19336896.2025.2560823 2025
Canadian 2021 H-type Bovine Spongiform Encephalopathy case associated with a novel E211K polymorphism in prion protein gene [0.03%]
加拿大2021年H型牛海绵脑病病例与新型E211K多态性有关
Waqas Tahir,Sandor Dudas,Renee Anderson et al.
Waqas Tahir et al.
Bovine Spongiform Encephalopathy (BSE) is a fatal neurodegenerative disease in cattle which can be either classical BSE (C-BSE) or atypical BSE (including H-BSE and L-BSE). Here, we report the results of our analyses of an H-BSE case found ...
Case Reports
Prion. 2025 Dec;19(1):36-49. DOI:10.1080/19336896.2025.2511933 2025
Impact of low testing numbers on chronic wasting disease apparent prevalence [0.03%]
低检测数量对慢性消耗性疾病表观流行率的影响
Jameson J Mori,Nelda A Rivera,William M Brown et al.
Jameson J Mori et al.
Chronic wasting disease (CWD) is a fatal, neurodegenerative disease of cervids, and its management heavily relies on diagnostic testing. Test results are commonly used to calculate 'apparent prevalence' (AP) - the percent of animals tested ...
Addressing chronic wasting disease in Korean farms: topsoil removal and 2N NaOH treatment before cervid restocking [0.03%]
韩国家养鹿场慢性消耗病的防控措施：除土和氢氧化钠处理后重新养殖黇鹿
Kyung-Je Park,Hoo-Chang Park,Yu-Ran Lee et al.
Kyung-Je Park et al.
Chronic wasting disease (CWD) is a highly contagious prion disease occurring in free-ranging and farmed cervids. In the Republic of Korea, cases of CWD continue to be detected almost annually, on both new and occasionally previously infecte...