Efficient induction of motor neuron disease in transgenic G93A SOD1 mice by prion-like seeding
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Mutations in superoxide dismutase 1 (SOD1) cause paralysis in familial amyotrophic lateral sclerosis and promote its misfolding into neurotoxic aggregates. Previous studies have shown that mice expressing the ALS-causing G85R variant of SOD1 develop paralysis ... ...
