Guo-Ying Yang,Zhen-Ge Luo
Guo-Ying Yang
Wnt ligands comprise a large family of secreted glycoproteins that control a variety of developmental processes including cell polarization in diverse organisms. Through various receptors present on receiving cells, Wnts initiate intracellu...
Ryan Insolera,She Chen,Song-Hai Shi
Ryan Insolera
A hallmark of neurons is their ability to polarize with dendrite and axon specification to allow the proper flow of information through the nervous system. Over the past decade, extensive research has been performed in an attempt to underst...
Tammy Szu-Yu Ho,Matthew N Rasband
Tammy Szu-Yu Ho
Neurons are highly polarized cells with distinct domains responsible for receiving, transmitting, and propagating electrical signals. Central to these functions is the axon initial segment (AIS), a short region of the axon adjacent to the c...
Takeo Katsuki,Rajshri Joshi,Deepak Ailani et al.
Takeo Katsuki et al.
Neurons are morphologically characterized by long processes extending from a cell body. These processes, the dendrites and axon, are major sub-cellular compartments defined by morphological, molecular, and functional differences. However, e...
Michael Stiess,Frank Bradke
Michael Stiess
The morphology of cells is key to their function. Neurons extend a long axon and several shorter dendrites to transmit signals in the nervous system. This process of neuronal polarization is driven by the cytoskeleton. The first and decisiv...
Melissa M Rolls
Melissa M Rolls
Drosophila neurons have identifiable axons and dendrites based on cell shape, but it is only just starting to become clear how Drosophila neurons are polarized at the molecular level. Dendrite-specific components including the Golgi complex...
Hooks and comets: The story of microtubule polarity orientation in the neuron [0.03%]
钩与彗星：神经元微管极性定向的故事
Peter W Baas,Shen Lin
Peter W Baas
It is widely believed that signature patterns of microtubule polarity orientation within axons and dendrites underlie compositional and morphological differences that distinguish these neuronal processes from one another. Axons of vertebrat...
Neuronal polarity in 2011 [0.03%]
2011年的神经元极性
Chris Q Doe,Kozo Kaibuchi
Chris Q Doe
Developmental mechanisms that regulate retinal ganglion cell dendritic morphology [0.03%]
调节视网膜节细胞树突形态的发育机制
Ning Tian
Ning Tian
One of the fundamental features of retinal ganglion cells (RGCs) is that dendrites of individual RGCs are confined to one or a few narrow strata within the inner plexiform layer (IPL), and each RGC synapses only with a small group of presyn...
Dicer is required for the maintenance of notch signaling and gliogenic competence during mouse retinal development [0.03%]
Dicer基因在小鼠视网膜发育过程中维持Notch信号传导和胶质细胞生成能力方面是必需的
Sean A Georgi,Thomas A Reh
Sean A Georgi
MicroRNAs (miRNAs) are 19-25 nucleotide RNAs that regulate messenger RNA translation and stability. Recently, we performed a conditional knockout (CKO) of the miRNA-processing enzyme Dicer during mouse retinal development and showed an esse...