The visual system of zebrafish and its use to model human ocular diseases [0.03%]
斑马鱼视觉系统及其在模拟人类眼病方面的应用
Gaia Gestri,Brian A Link,Stephan C F Neuhauss
Gaia Gestri
Free swimming zebrafish larvae depend mainly on their sense of vision to evade predation and to catch prey. Hence, there is strong selective pressure on the fast maturation of visual function and indeed the visual system already supports a ...
Caghan Kizil,Jan Kaslin,Volker Kroehne et al.
Caghan Kizil et al.
Adult neurogenesis is a widespread trait of vertebrates; however, the degree of this ability and the underlying activity of the adult neural stem cells differ vastly among species. In contrast to mammals that have limited neurogenesis in th...
Michèle Studer
Michèle Studer
Filippo Del Bene,Claire Wyart
Filippo Del Bene
Zebrafish became a model of choice for neurobiology because of the transparency of its brain and because of its amenability to genetic manipulation. In particular, at early stages of development the intact larva is an ideal system to apply ...
Genetic dissection of the zebrafish habenula, a possible switching board for selection of behavioral strategy to cope with fear and anxiety [0.03%]
遗传解剖斑马鱼纹状体 Hab 核，可能用于选择应对恐惧和焦虑的行为策略的转换板
Hitoshi Okamoto,Masakazu Agetsuma,Hidenori Aizawa
Hitoshi Okamoto
The habenula is a part of an evolutionarily highly conserved conduction pathway within the limbic system that connects telencephalic nuclei to the brain stem nuclei such as interpeduncular nucleus(IPN), the ventral tegmental area (VTA), and...
Laura Torres-Benito,Rocío Ruiz,Lucía Tabares
Laura Torres-Benito
Proximal spinal muscular atrophy, the most frequent genetic cause of childhood lethality, is caused by homozygous loss or mutation of the SMN1 gene on human chromosome 5, which codes for the survival motor neuron (SMN) protein. SMN plays a ...
Jorn Schweitzer,Heiko Lohr,Alida Filippi et al.
Jorn Schweitzer et al.
Dopaminergic and noradrenergic neurons constitute some of the major far projecting systems in the vertebrate brain and spinal cord that modulate the activity of circuits controlling a broad range of behaviors. Degeneration or dysfunction of...
Jason Rihel,Alexander F Schier
Jason Rihel
The larval zebrafish has emerged asa vertebrate model system amenable to small molecule screens for probing diverse biological pathways. Two large-scale small molecule screens examined the effects of thousands of drugs on larval zebrafish s...
Kara L Cerveny,Mate Varga,Stephen W Wilson
Kara L Cerveny
Fish and amphibia are capable of lifelong growth and regeneration. The two core components of their visual system, the retina and tectum both maintain small populations of stem cells that contribute new neurons and glia to these tissues as ...
Giovanni Esposito,Fernandes Ana Clara,Patrik Verstreken
Giovanni Esposito
Presynaptic terminals maintain neurotransmitter release during repeated rounds of stimulation using local recycling of synaptic vesicles (SV). During each SV cycle, protein complex assembly and disassembly results in accumulation of inactiv...