Intracellular trafficking in Drosophila visual system development: a basis for pattern formation through simple mechanisms [0.03%]
果蝇视觉系统发育中的细胞内运输：通过简单机制形成图案的基础
Chih-Chiang Chan,Daniel Epstein,P Robin Hiesinger
Chih-Chiang Chan
Intracellular trafficking underlies cellular functions ranging from membrane remodeling to receptor activation. During multicellular organ development, these basic cell biological functions are required as both passive machinery and active ...
Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions [0.03%]
整合素与细胞外基质在轴突生长和导向中的作用机制研究
Jonathan P Myers,Miguel Santiago-Medina,Timothy M Gomez
Jonathan P Myers
Developing neurons use a combination of guidance cues to assemble a functional neural network. A variety of proteins immobilized within the extracellular matrix (ECM) provide specific binding sites for integrin receptors on neurons. Integri...
Expression of BDNF and NT-3 during the ontogeny and regeneration of the lacertidian (Gallotia galloti) visual system [0.03%]
壁虎视神经生长和再生过程中脑源性神经营养因子和神经节段肽的表达模式研究
E Santos,M M Romero-Alemán,M Monzón-Mayor et al.
E Santos et al.
Retinal ganglion cell (RGC) axons regrow spontaneously after optic nerve (ON) transection in G. galloti. Because brain-derived neurotrophic factor (BDNF) is considered the major neurotrophin participating in vertebrate visual system develop...
Florencia Cavodeassi,Corinne Houart
Florencia Cavodeassi
Our knowledge of the general mechanisms controlling the formation of the vertebrate central nervous system has advanced tremendously in the last decade. Here, we discuss the impact of the combined use of cell manipulation, in vivo imaging a...
Sally W Chege,Gabriela A Hortopan,Matthew T Dinday et al.
Sally W Chege et al.
Members of the K(v)7 family generate a subthreshold potassium current, termed M-current, that regulates the excitability of principal central neurons. Mutations in two members of this family, K(v)7.2 (KCNQ2) and K(v)7.3 (KCNQ3) are associat...
Jing W Wang
Jing W Wang
Most animals are endowed with an olfactory system that is essential for finding foods, avoiding predators, and locating mating partners. The olfactory system must encode the identity and intensity of behaviorally relevant stimuli in a dynam...
Kendal Broadie,Stefan Baumgartner,Andreas Prokop
Kendal Broadie
Extracellular matrix (ECM) and matrix receptors are intimately involved in most biological processes. The ECM plays fundamental developmental and physiological roles in health and disease, including processes underlying the development, mai...
Multiple transcription factor families regulate axon growth and regeneration [0.03%]
多个转录因子族调控轴突生长和再生
Darcie L Moore,Jeffrey L Goldberg
Darcie L Moore
Understanding axon regenerative failure remains a major goal in neuroscience, and reversing this failure remains a major goal for clinical neurology. Although an inhibitory central nervous system environment clearly plays a role, focus on m...
Binocular maps in Xenopus tectum: Visual experience and the development of isthmotectal topography [0.03%]
视皮层的双目视觉地图：视觉经验和脑桥 optic-tectal 投射拓扑的关系
Susan B Udin
Susan B Udin
Xenopus frogs have a prominent binocular field that develops as a consequence of the migration of the eyes during the remodeling of the head during and after metamorphosis. In the optic tectum, a topographic representation of the ipsilatera...
Paul Beatus,Dhanisha J Jhaveri,Tara L Walker et al.
Paul Beatus et al.
The regulation of neural precursor cell (NPC) activity is the major determinant of the rate of neuronal production in neurogenic regions of the adult brain. Here, we show that Oncostatin M (Osm) and its receptor, OsmRβ, are both expressed ...