Integrins and the extracellular matrix: key mediators of development and regeneration of the sensory nervous system [0.03%]
整合素和细胞外基质：感觉神经系统的发育和再生的关键调节因子
Natalie J Gardiner
Natalie J Gardiner
The somatosensory nervous system is responsible for the transmission of a multitude of sensory information from specialized receptors in the periphery to the central nervous system. Sensory afferents can potentially be damaged at several si...
Carlos Oliva,Pía Escobedo,César Astorga et al.
Carlos Oliva et al.
Synaptic function is crucially dependent on the spatial organization of the presynaptic and postsynaptic apparatuses and the juxtaposition of both membrane compartments. This precise arrangement is achieved by a protein network at the subme...
Intrinsic properties guide proximal abducens and oculomotor nerve outgrowth in avian embryos [0.03%]
固有属性引导禽类胚胎的展神经和动眼神经的近端生长路径
Cynthia Lance-Jones,Veeral Shah,Drew M Noden et al.
Cynthia Lance-Jones et al.
Proper movement of the vertebrate eye requires the formation of precisely patterned axonal connections linking cranial somatic motoneurons, located at defined positions in the ventral midbrain and hindbrain, with extraocular muscles. The ai...
Biophysics of substrate interaction: influence on neural motility, differentiation, and repair [0.03%]
基底突起相互作用的生物物理作用：对神经运动、分化和修复的影响
Simon W Moore,Michael P Sheetz
Simon W Moore
The identity and behavior of a cell is shaped by the molecular and mechanical composition of its surroundings. Molecular cues have firmly established roles in guiding both neuronal fate decisions and the migration of cells and axons. Howeve...
Extracellular matrix functions during neuronal migration and lamination in the mammalian central nervous system [0.03%]
哺乳动物中枢神经系统中细胞外基质在神经元迁移和分层过程中的功能作用
Santos J Franco,Ulrich Müller
Santos J Franco
Extracellular matrix (ECM) glycoproteins are expressed in the central nervous system (CNS) in complex and developmentally regulated patterns. The ECM provides a number of critical functions in the CNS, contributing both to the overall struc...
Renée H M Felt,Eduard J H Mulder,Annemarie B Lüchinger et al.
Renée H M Felt et al.
Motility assessment before birth can be used to evaluate the integrity of the nervous system. Sideways bending (SB) of head and/or rump, the earliest embryonic motility in both humans and guinea pigs, can be visualized sonographically. We k...
Epithelial membrane transporters expression in the developing to adult mouse vomeronasal organ and olfactory mucosa [0.03%]
小鼠犁鼻器和嗅粘膜上皮膜转运体的表达由发育到成年
Flavia Merigo,Carla Mucignat-Caretta,Mirko Cristofoletti et al.
Flavia Merigo et al.
To contribute clarifying mechanisms operating in nose chemosensory epithelia and their developmental patterns, we analyzed the expression of different epithelial membrane transporters as well as the Clara cell secretory protein, CC26 in the...
Visuospatial information in the retinotectal system of xenopus before correct image formation by the developing eye [0.03%]
发育中的眼睛正确成像之前蛙视网膜至间脑的信息传递
Blake A Richards,Joram J van Rheede,Colin J Akerman
Blake A Richards
The retinotectal pathway of Xenopus laevis is a well-established experimental model for studying activity-dependent processes during visual system development. Such processes can be guided by stimulus-evoked activity patterns, which depend ...
Neonatal fluoxetine exposure alters motor performances of adolescent rats [0.03%]
新生幼鼠接触氟西汀影响大鼠的运动表现
Li-Jen Lee,Lukas Jyuhn-Hsiarn Lee
Li-Jen Lee
Growing evidence from human and animal studies has shown adverse consequences of maternal usage of antidepressants in their newborn babies. To study the effects of early antidepressant exposure on motor function later in life, we treated ne...
Induction of axon growth arrest without growth cone collapse through the N-terminal region of four-transmembrane glycoprotein M6a [0.03%]
四次跨膜糖蛋白M6a的N端通过非生长锥塌陷机制诱导轴突生长停止
Yasufumi Sato,Sakura Mita,Nanae Fukushima et al.
Yasufumi Sato et al.
During development, axons elongate vigorously, carefully controlling their speed, to connect with their targets. In general, rapid axon growth is correlated with active growth cones driven by dynamic actin filaments. For example, when the a...