A C-terminal motif containing a PKC phosphorylation site regulates γ-Protocadherin-mediated dendrite arborization in the cerebral cortex in vivo [0.03%]
CT端含PKC磷酸化位点的调节基序在体内调节γ-原钙黏蛋白介导的脑皮层树突形态发生
Camille M Hanes,Kar Men Mah,David M Steffen et al.
Camille M Hanes et al.
The Pcdhg gene cluster encodes 22 γ-Protocadherin (γ-Pcdh) cell adhesion molecules that critically regulate multiple aspects of neural development, including neuronal survival, dendritic and axonal arborization, and synapse formation and ...
Impact of food additives on neurodevelopmental processes in zebrafish (Danio rerio): Exploring circadian clock genes and dopamine system [0.03%]
食品添加剂对斑马鱼神经发育过程的影响：探讨昼夜节律钟基因和多巴胺系统
L Divya Christy,K Vignesh,Jayshree Nellore et al.
L Divya Christy et al.
Assessing the impact of food additives on neurodevelopmental processes extends beyond traditional acute toxicity evaluations to address subtler, long-term effects. This study investigates the impact of common food additives (tartrazine, sun...
Forebrain commissure formation in zebrafish embryo requires the binding of KLC1 to CRMP2 [0.03%]
KLC1与CRMP2的相互作用对于斑马鱼前脑连合的形成是必需的
Simo Li,Youjia Guo,Miyuki Takahashi et al.
Simo Li et al.
Formation of the corpus callosum (CC), anterior commissure (AC), and postoptic commissure (POC), connecting the left and right cerebral hemispheres, is crucial for cerebral functioning. Collapsin response mediator protein 2 (CRMP2) has been...
Comparative model of minimal spinal cord injury reveals a rather anti-inflammatory response in the lesion site as well as increased proliferation in the central canal lining in the neonates compared to the adult rats [0.03%]
最小脊髓损伤模型显示，在病变部位，与成年大鼠相比，新生仔鼠表现出相对抗炎反应以及中央管衬里的增殖增强
Juraj Ševc,Filip Mochnacký,Ján Košuth et al.
Juraj Ševc et al.
Spinal cord injury (SCI) resulting from trauma decreases the quality of human life. Numerous clues indicate that the limited endogenous regenerative potential is a result of the interplay between the inhibitory nature of mature nervous tiss...
Comparative Study
Developmental neurobiology. 2024 Jul;84(3):169-190. DOI:10.1002/dneu.22942 2024
Rare heterozygous genetic variants of NRXN and NLGN gene families involved in synaptic function and their association with neurodevelopmental disorders [0.03%]
与神经发育障碍相关的罕见的NRXN和NLGN基因家族的杂合变异及其与突触功能的关系
Hamide Betul Gerik-Celebi,Hilmi Bolat,Gul Unsel-Bolat
Hamide Betul Gerik-Celebi
The interaction of neurexins (NRXNs) in the presynaptic membrane with postsynaptic cell adhesion molecules called neuroligins (NLGNs) is critical for this synaptic function. Impaired synaptic functions are emphasized in neurodevelopmental d...
Pregestational fructose-induced metabolic syndrome in Wistar rats causes sexually dimorphic behavioral changes in their offspring [0.03%]
怀孕前的果糖引起的代谢综合征会影响大鼠后代的行为变化
Marié L Cuervo Sánchez,Facundo H Prado Spalm,Natalia E Furland et al.
Marié L Cuervo Sánchez et al.
Metabolic syndrome (MetS), marked by enduring metabolic inflammation, has detrimental effects on cognitive performance and brain structure, influencing behavior. This study aimed to investigate whether maternal MetS could negatively impact ...
Microglia undergo disease-associated transcriptional activation and CX3C motif chemokine receptor 1 expression regulates neurogenesis in the aged brain [0.03%]
小胶质细胞发生与疾病相关的转录激活和CX3C基序趋化因子受体1的表达调节衰老大脑中的神经发生
Jonas Fritze,Chandramouli Muralidharan,Eleanor Stamp et al.
Jonas Fritze et al.
Adult neurogenesis continues throughout life but declines dramatically with age and in neurodegenerative disorders such as Alzheimer's disease. In parallel, microglia become activated resulting in chronic inflammation in the aged brain. A u...
Oxygen and HIF1α-dependent SDF1 expression in primary astrocytes [0.03%]
原代星形胶质细胞中氧气和HIF1α依赖性SDF1的表达
Andreas Pietrucha,Meray Serdar,Ivo Bendix et al.
Andreas Pietrucha et al.
In the naturally hypoxic in utero fetal environment of preterm infants, oxygen and oxygen-sensitive signaling pathways play an important role in brain development, with hypoxia-inducible factor-1α (HIF1α) being an important regulator. Ear...
Ongoing effects of preterm birth on the dopaminergic and noradrenergic pathways in the frontal cortex and hippocampus of guinea pigs [0.03%]
早产对 Guinea Pig 前额叶皮质和海马区多巴胺能和去甲肾上腺素能通路的持续影响
Roisin A Moloney,Hannah K Palliser,Rebecca M Dyson et al.
Roisin A Moloney et al.
Children born preterm have an increased likelihood of developing neurobehavioral disorders such as attention-deficit hyperactivity disorder (ADHD) and anxiety. These disorders have a sex bias, with males having a higher incidence of ADHD, w...
Cerebellar granule cell migration and folia development require Mllt11/Af1q/Tcf7c [0.03%]
脑小叶颗粒细胞迁移和叶片发育需要Mllt11 / Af1q / Tcf7c
Marley Blommers,Danielle Stanton-Turcotte,Emily A Witt et al.
Marley Blommers et al.
The organization of neurons into distinct layers, known as lamination, is a common feature of the nervous system. This process, which arises from the direct coupling of neurogenesis and neuronal migration, plays a crucial role in the develo...