Elevated Serum Homocysteine Levels Impair Embryonic Neurodevelopment by Dysregulating the Heat Shock Proteins [0.03%]
同型半胱氨酸通过调节热休克蛋白影响胚胎神经发育
Jia Mai,Ling Yang,Min Wang et al.
Jia Mai et al.
Observational studies have found that elevated serum homocysteine (Hcy) levels during pregnancy may be associated with the occurrence of neural tube defects (NTDs). However, the effect of Hcy on fetal neural development and its underlying m...
Investigating the Effect of Capric Acid on Antibiotic-Induced Autism-Like Behavior in Rodents [0.03%]
研究月桂酸对啮齿类动物抗生素诱导的自闭症样行为的影响
Nikhila Shekhar,Ajit Kumar Thakur
Nikhila Shekhar
Owing to the high prevalence of gastrointestinal dysfunction in patients, the gut-brain axis is considered to play a vital role in neurodevelopment diseases. Recent pieces of evidence have pointed to the usage of antibiotics at an early dev...
Overexpression of Growth Differentiation Factor 15 Reduces Neuronal Cell Damage Induced by Oxygen-Glucose Deprivation/Reoxygenation via Inhibiting Endoplasmic Reticulum Stress-Mediated Ferroptosis [0.03%]
生长分化因子15过表达通过抑制内质网应激介导的铁死亡减少氧糖剥夺/复氧诱导的神经元细胞损伤
Haiming Li,Bin Chen,Zhelin Chen et al.
Haiming Li et al.
Growth differentiation factor 15 (GDF15) can be induced under various stress conditions. This study aimed to explore the role of GDF15 in oxygen-glucose deprivation/reoxygenation (OGD/R)-induced HT22 cells. OGD/R was employed to induce the ...
Novel Transgenic Zebrafish Lines to Study the CHRNA3-B4-A5 Gene Cluster [0.03%]
用于研究CHRNA3-B4-A5基因簇的新转基因斑马鱼品系
Yuanqi Hua,Judith Habicher,Matthias Carl et al.
Yuanqi Hua et al.
Acetylcholine (ACh), a vital neurotransmitter for both the peripheral (PNS) and central nervous systems (CNS), signals through nicotinic ACh receptors (nAChRs) and muscarinic ACh receptors (mAChR). Here, we explore the expression patterns o...
Defective Hippocampal Primary Ciliary Function and Aberrant LKB1/AMPK Signaling Pathway Are Associated With the Inhibition of Autophagic Activity in Offspring Born to Mothers of Advanced Maternal Age [0.03%]
母龄老化后代海马初级纤毛功能缺陷和LKB1/AMPK信号通路异常抑制了后代自噬活性
Ziyao Han,Xiaoyue Yang,Jianxiong Gui et al.
Ziyao Han et al.
Advanced maternal age (AMA) negatively influences the development and cognitive functions of offspring. However, the underlying mechanism remains to be elucidated. As hippocampal autophagy and primary cilia play a crucial role in learning a...
Effects of Cannabidiol Isolated or in Association With Risperidone in an Animal Model of Autism [0.03%]
大麻二酚或与利培酮联合用于自闭症动物模型中的作用研究
Maiara de Aguiar da Costa,Gustavo Zanette Fernandes,Eduarda Maiochi et al.
Maiara de Aguiar da Costa et al.
Autism spectrum disorder (ASD) is characterized by deficits in communication, social interaction, and repetitive and stereotyped behaviors, with no specific drug therapy available. Studies have found that cannabidiol (CBD) can improve hyper...
Cellularity Defects Are Not Ubiquitous in the Brains of Fetuses With Down Syndrome [0.03%]
唐氏综合症胎儿脑部并不普遍存在细胞缺陷
Marco Emili,Fiorenza Stagni,Maria Paola Bonasoni et al.
Marco Emili et al.
Down syndrome (DS) is a genetic pathology characterized by various developmental defects. Unlike other clinical problems, intellectual disability is an invariant clinical trait of DS. Impairment of neurogenesis accompanied by brain hypotrop...
Dysregulation of parvalbumin expression and neurotransmitter imbalance in the auditory cortex of the BTBR mouse model of autism spectrum disorder [0.03%]
自闭症谱系障碍BTBR小鼠模型中听觉皮层神经递质失衡和色素上白蛋白表达异常
Binliang Tang,Jingting Zhao,Cui Zhang et al.
Binliang Tang et al.
Individuals diagnosed with autism spectrum disorder (ASD) frequently exhibit abnormalities in auditory perception, a phenomenon potentially attributed to alterations in the excitatory and inhibitory cells constituting cortical circuits. How...
Efficient Dlx2-mediated astrocyte-to-neuron conversion and inhibition of neuroinflammation by NeuroD1 [0.03%]
NeuroD1介导的高效星形胶质细胞重编程及神经炎症抑制作用研究
Min-Hui Liu,Yu-Ge Xu,Xiao-Ni Bai et al.
Min-Hui Liu et al.
In vivo astrocyte-to-neuron (AtN) conversion induced by overexpression of neural transcriptional factors has great potential for neural regeneration and repair. Here, we demonstrate that a single neural transcriptional factor, Dlx2, convert...
Application of electrostimulation and magnetic stimulation in patients with optic neuropathy: A mechanistic review [0.03%]
电刺激和磁刺激在视神经病变患者中的应用：机制综述
Mohammad Reza Khalili,Athar Shadmani,Fatemeh Sanie-Jahromi
Mohammad Reza Khalili
Visual impairment caused by optic neuropathies is irreversible because retinal ganglion cells (RGCs), the specialized neurons of the retina, do not have the capacity for self-renewal and self-repair. Blindness caused by optic nerve neuropat...