Udit Kumar Dash,Aparna Tripathi,Debashree Mazumdar et al.
Udit Kumar Dash et al.
Hepatic failure is a severe condition marked by the progressive or sudden loss of liver function, broadly categorized into acute liver failure (ALF), which develops within days to weeks, and chronic liver failure (CLF), which evolves over m...
A Novel Homozygous TBC1D2B Variant Disrupts Functional Domains and Suggests Impaired Rab-GTPase Regulation in Neurodevelopmental Disorder [0.03%]
一个新的TBC1D2B纯合变异破坏了功能域并暗示在神经发育障碍中对Rab-GTP酶的调节受损
Murat Ozturk,Cahide Bulut Arslan,Ekrem Akbulut et al.
Murat Ozturk et al.
Recent reports have linked biallelic loss-of-function variants in the TBC1D2B gene to neurodevelopmental disorder with seizures and gingival overgrowth (NEDSGO) (OMIM 619323), a rare condition characterized by seizures and gingival hyperpla...
Neuroinflammatory Pathways in Autism Spectrum Disorder: Unraveling the Role of Sirtuin 1 in Clinical Samples [0.03%]
自闭症谱系障碍中的神经炎症途径：在临床样本中揭示Sirtuin 1的作用
Merve Cikili-Uytun,Esra Yurumez,Banu Kaymak et al.
Merve Cikili-Uytun et al.
Despite extensive research, the etiological factors contributing to autism spectrum disorder (ASD) remain incompletely understood, with potential influences ranging from genetic predispositions to environmental factors. Sirtuin 1 (SIRT1), a...
Dectin-1 Drives Diabetic Retinopathy via Inducing Microglia-Mediated Inflammation and Blood-Retinal Barrier Breakdown [0.03%]
Dectin-1通过诱导小胶质细胞介导的炎症和血视网膜屏障破坏驱动糖尿病性视网膜病变
Lei Zhang,Sumei Zhang,Yingjun Li et al.
Lei Zhang et al.
Diabetic retinopathy (DR), a prevailing manifestation among diabetic patients, occurs as a major sight-threatening disorder. Dectin-1, as an innate immune receptor, has been notified as a critical modulator of diabetes mellitus. In this con...
Wenfeng Li,Lili Zhang,Shaozong Chen
Wenfeng Li
Chronic visceral pain is the primary symptom of functional gastrointestinal disorders, affecting up to 20% of the population. It involves peripheral sensitization in the peripheral nervous system and central sensitization in the central ner...
Could the Polymorphisms of DOCK4 (rs147636134), SYNGAP1 (rs199759879), and FOXP1 (rs767001715) be the Primary Risk Factors for Bipolar Disorder and Autism Spectrum Disorder? [0.03%]
DOCK4（rs147636134）、SYNGAP1（rs199759879）和FOXP1（rs767001715）的多态性可能是双相情感障碍和自闭症谱系障碍的主要风险因素吗？
Elvan Çiftçi,Nimet Sağlam,Tayfun Gözler et al.
Elvan Çiftçi et al.
Autism spectrum disorder (ASD) and bipolar disorder (BD) are psychiatric diseases that may overlap in common neurodevelopmental and genetic basis. Forkhead Box P1 (FOXP1), Synaptic Ras GTPase-activating protein 1 (SYNGAP1), and Dedicator of...
Neonatal Procedural Pain Disrupts Phosphorylation of KCC2 in the Spinal Cord [0.03%]
新生儿疼痛干扰脊髓KCC2的磷酸化
Mathilde Baudat,Elbert A J Joosten,Sinno H P Simons et al.
Mathilde Baudat et al.
Neonatal procedural pain experienced in the neonatal intensive care unit can lead to long-lasting remodeling of the central nervous system and, in particular, of the spinal nociceptive network. Preclinical studies indicate a disrupted inhib...
Efficacy of midazolam in the Treatment of Acute Convulsions in Children and Its Effects on Convulsive Brain Tissue Injury [0.03%]
咪达唑仑治疗儿童急性惊厥的疗效及其对惊厥脑组织损伤的影响研究
Jing Zhang,Jing Dong,Ling Jiang et al.
Jing Zhang et al.
This study focused on addressing the efficacy of midazolam in the treatment of acute convulsions in children and its effects on convulsive brain tissue injury. A total of 124 children with acute convulsions were separated into the control g...
EMC10 Gene Variants May Cause Dual Molecular Effects on the Neuropsychiatric Disease Pattern [0.03%]
EMC10基因变异可能对神经精神疾病模式产生双重分子效应
Hilmi Bolat,Dilan Genç Akdağ,Gül Ünsel-Bolat
Hilmi Bolat
The EMC10 gene on chromosome 19 encodes one of the highly conserved endoplasmic reticulum membrane complexes (EMC). Specific mutations in EMC10 cause a disorder known as neurodevelopmental disorder with dysmorphic facies and variable seizur...
Prolactin Secretion During Postnatal Development in Artificial Rearing Rats (Rattus norvegicus) [0.03%]
人工饲养大鼠（棕色 Norway 大鼠）产后发育期间的催乳素分泌
César G Toriz,Ángel I Melo,Brenda B García-Iglesias et al.
César G Toriz et al.
During the lactation period, rat pups are fed by their mother and are with their siblings. In the pituitary, lactotrope and somatolactotrope cells increase in number during this period and are associated with milk-borne factors. In the arti...