Effects of early-life stress and sex on blood-brain barrier permeability and integrity in juvenile and adult rats [0.03%]
早期应激和性别对幼年及成年大鼠血脑屏障通透性和完整性的的影响
Anna Solarz,Iwona Majcher-Maślanka,Agnieszka Chocyk
Anna Solarz
Early-life stress (ELS) is considered a relevant etiological factor for neurodegenerative and mental disorders. In the present study, we hypothesized that ELS may persistently and sex dependently influence blood-brain barrier (BBB) integrit...
Developmental exposure to the synthetic progestin, 17α-hydroxyprogesterone caproate, disrupts the mesocortical serotonin pathway and alters impulsive decision-making in rats [0.03%]
合成孕激素17α-羟基黄体酮己酸盐的发育暴露会破坏纹状皮质5-HT通路并改变大鼠冲动性决策行为
Allyssa Fahrenkopf,Grace Li,Ruth I Wood et al.
Allyssa Fahrenkopf et al.
The synthetic progestin, 17α-hydroxyprogesterone caproate (17-OHPC), is administered to women at risk for preterm birth during a critical period of fetal development for mesocortical pathways. Yet, little information is available regarding...
Developmental maturation of presynaptic ribbon numbers in chicken basilar-papilla hair cells and its perturbation by long-term overexpression of Wnt9a [0.03%]
鸡基底螺旋神经节神经元中耳蜗毛细胞 presynaptic 突触囊泡串的数量发育成熟及其被 Wnt9a 长期过表达干扰的现象
M Queralt Caus Capdevila,Ulrike J Sienknecht,Christine Köppl
M Queralt Caus Capdevila
The avian basilar papilla is a valuable model system for exploring the developmental determination and differentiation of sensory hair cells and their innervation. In the mature basilar papilla, hair cells form a well-known continuum betwee...
Effects of deubiquitylases on the biological behaviors of neural stem cells [0.03%]
去泛素酶对神经干细胞生物学行为的影响
Qiqi Zhao,Yixin Li,Xixun Du et al.
Qiqi Zhao et al.
New neurons are generated throughout life in distinct regions of the mammalian brain due to the proliferation and differentiation of neural stem cells (NSCs). Ubiquitin, a post-translational modification of cellular proteins, is an importan...
Dynamics of microglia and dendritic spines in early adolescent cortex after developmental alcohol exposure [0.03%]
发育性酒精暴露后青春期早期大脑皮层的小胶质细胞和树突棘的动态变化规律研究
Elissa L Wong,Alexandra Strohm,Jason Atlas et al.
Elissa L Wong et al.
Fetal alcohol spectrum disorder patients suffer from many cognitive disabilities. These include impaired auditory, visual, and tactile sensory information processing, making it more difficult for these patients to learn to navigate social s...
Leucine-rich repeats and immunoglobulin-like domains 1 deficiency affects hippocampal dendrite complexity and impairs cognitive function [0.03%]
富含亮氨酸重复序列和免疫球蛋白样结构域的缺乏影响海马树突复杂度并损害认知功能
Francisco Javier Hita,Pedro Bekinschtein,Fernanda Ledda et al.
Francisco Javier Hita et al.
Leucine-rich repeat (LRR) transmembrane proteins have been directly linked to neurodevelopmental and cognitive disorders. We have previously shown that the LRR transmembrane protein, leucine-rich repeats and immunoglobulin-like domains 1 (L...
Aging affects cognition and hippocampal ultrastructure in male Wistar rats [0.03%]
衰老会影响雄性Wistar大鼠的认知和海马极超微结构
Nino Lomidze,Mzia G Zhvania,Yousef Tizabi et al.
Nino Lomidze et al.
It is now well established that aging is associated with emotional and cognitive changes. Although the basis of such changes is not fully understood, ultrastructural alterations in key brain areas are likely contributing factors. Recently, ...
CG11426 gene product negatively regulates glial population size in the Drosophila eye imaginal disc [0.03%]
CG11426基因编码的产物通过抑制星形胶质细胞数量负向调控果蝇眼 imaginal disc的大小
Jong-Eun Rhee,Jin-Hyeon Choi,Jae H Park et al.
Jong-Eun Rhee et al.
Glial cells play essential roles in the nervous system. Although glial populations are tightly regulated, the mechanisms regulating the population size remain poorly understood. Since Drosophila glial cells are similar to the human counterp...
Ultrastructural analysis of dendritic spine necks reveals a continuum of spine morphologies [0.03%]
超显微结构分析揭示了脊柱颈的形态变化连续性
Netanel Ofer,Daniel R Berger,Narayanan Kasthuri et al.
Netanel Ofer et al.
Dendritic spines are membranous protrusions that receive essentially all excitatory inputs in most mammalian neurons. Spines, with a bulbous head connected to the dendrite by a thin neck, have a variety of morphologies that likely impact th...
GSK-3β S9A overexpression leads murine hippocampal neural precursors to acquire an astroglial phenotype in vivo [0.03%]
GSK-3βS9A过表达使小鼠海马神经前体细胞在体内获得星形胶质细胞表型
Miguel Flor-García,Jesús Ávila,María Llorens-Martín
Miguel Flor-García
The addition of new neurons to the existing hippocampal circuitry persists in the adult dentate gyrus (DG). During this process, named adult hippocampal neurogenesis (AHN), adult hippocampal progenitor cells (AHPs) give rise to newborn dent...