Characterization of neurological disease progression in a canine model of CLN5 neuronal ceroid lipofuscinosis [0.03%]
克林五型神经 ceroid 氯脂病犬模型中神经退行性疾病进展的特征研究
Elizabeth J Meiman,Grace Robinson Kick,Cheryl A Jensen et al.
Elizabeth J Meiman et al.
Golden Retriever dogs with a frameshift variant in CLN5 (c.934_935delAG) suffer from a progressive neurodegenerative disorder analogous to the CLN5 form of neuronal ceroid lipofuscinosis (NCL). Five littermate puppies homozygous for the del...
Refinement of axonal conduction and myelination in the mouse optic nerve indicate an extended period of postnatal developmental plasticity [0.03%]
小鼠视神经轴突传导的精炼和髓鞘化表明存在延长的产后发育可塑期
Annika Balraj,Cheryl Clarkson-Paredes,Ahdeah Pajoohesh-Ganji et al.
Annika Balraj et al.
Retinal ganglion cells generate a pattern of action potentials to communicate visual information from the retina to cortical areas. Myelin, an insulating sheath, wraps axonal segments to facilitate signal propagation and when deficient, can...
Polycomb-mediated gene regulation in human brain development and neurodevelopmental disorders [0.03%]
多梳蛋白介导的人脑发育和神经发育障碍中的基因调控
Nora Bölicke,Mareike Albert
Nora Bölicke
The neocortex is considered the seat of higher cognitive function in humans. It develops from a sheet of neural progenitor cells, most of which eventually give rise to neurons. This process of cell fate determination is controlled by precis...
Cortical myelination in toddlers and preschoolers with autism spectrum disorder [0.03%]
自闭症谱系障碍幼儿的大脑髓鞘化过程研究
Bosi Chen,Annika Linke,Lindsay Olson et al.
Bosi Chen et al.
Intracortical myelin is thought to play a significant role in the development of neural circuits and functional networks, with consistent evidence of atypical network connectivity in children with autism spectrum disorder (ASD). However, li...
Re-evaluating the actin-dependence of spectraplakin functions during axon growth and maintenance [0.03%]
斑马鱼轴突生长和维持过程中谱蛋白包蛋白功能的肌动蛋白依赖性的再评估
Yue Qu,Juliana Alves-Silva,Kriti Gupta et al.
Yue Qu et al.
Axons are the long and slender processes of neurons constituting the biological cables that wire the nervous system. The growth and maintenance of axons require loose microtubule bundles that extend through their entire length. Understandin...
Dusan Hirjak,Gudrun M Henemann,Mike M Schmitgen et al.
Dusan Hirjak et al.
Excessive smartphone use has been repeatedly related to adverse effects on mental health and psychological well-being in young adults. The continued investigation of the neurobiological mechanism underlying excessive smartphone use-sometime...
Developmental neural activity requires neuron-astrocyte interactions [0.03%]
发育性神经活动需要神经元-星形胶质细胞相互作用
Bryce T Bajar,Nguyen T Phi,Harpreet Randhawa et al.
Bryce T Bajar et al.
Developmental neural activity is a common feature of neural circuit assembly. Although glia have established roles in synapse development, the contribution of neuron-glia interactions to developmental activity remains largely unexplored. He...
Coactivator-associated arginine methyltransferase 1 controls oligodendrocyte differentiation in the corpus callosum during early brain development [0.03%]
协同激活剂相关精氨酸甲基转移酶1在早期脑发育过程中控制胼胝体少突胶质细胞分化
Yugo Ishino,Shoko Shimizu,Masaya Tohyama et al.
Yugo Ishino et al.
Protein arginine methylation has been recognized as one of key posttranslational modifications for refined protein functions, mediated by protein arginine methyltransferases (Prmts). Coactivator-associated arginine methyltransferase (Carm1,...
Maternal deprivation and milk replacement affect the integrity of gray and white matter in the developing lamb brain [0.03%]
母体剥夺和牛奶替代影响发育羔羊大脑灰质和白质的完整性
Scott A Love,Emmanuelle Haslin,Manon Bellardie et al.
Scott A Love et al.
The psychoendocrine evaluation of lamb development has demonstrated that maternal deprivation and milk replacement alters health, behavior, and endocrine profiles. While lambs are able to discriminate familiar and non-familiar conspecifics ...
Celsr family genes are dynamically expressed in embryonic and juvenile zebrafish [0.03%]
原钙粘着蛋白基因家族在斑马鱼胚胎及幼体期的动态表达
Bhagyashri Joshi,Himanshu Gaur,Subhra Prakash Hui et al.
Bhagyashri Joshi et al.
The Cadherin EGF LAG seven-pass G-type receptor (Celsr) family belongs to the adhesion G-protein coupled receptor superfamily. In most vertebrates, the Celsr family has three members (CELSR1-3), whereas zebrafish display four paralogues (ce...