CRMP2 and CRMP4 are required for the formation of commissural tracts in the developing zebrafish forebrain [0.03%]
CRMP2和CRMP4是斑马鱼发育中脑前脑联合纤维形成的必要条件
Youjia Guo,Carolina Fiallos Oliveros,Toshio Ohshima
Youjia Guo
Axonal connections between the two sides of the brain are essential for processing sensorimotor functions, especially in animals with bilateral symmetry. The anterior commissure and postoptic commissure are two crucial axonal projections th...
Dachshund acts with Abdominal-B to trigger programmed cell death in the Drosophila central nervous system at the frontiers of Abd-B expression [0.03%]
腹侧Abdominal-B的作用触发果蝇中枢神经系统腹侧Abd-B表达边界处的程序性细胞死亡事件
Luis Clarembaux-Badell,Pablo Baladrón-de-Juan,Hugo Gabilondo et al.
Luis Clarembaux-Badell et al.
A striking feature of the nervous system pertains to the appearance of different neural cell subtypes at different axial levels. Studies in the Drosophila central nervous system reveal that one mechanism underlying such segmental difference...
Sara Tucker Edmister,Robbert Creton
Sara Tucker Edmister
Calcineurin signaling pathways are suppressed in Down syndrome (trisomy 21), by overexpression of genes that are located on chromosome 21. Two key genes are the regulator of calcineurin 1 (RCAN1), also called the Down syndrome critical regi...
Evolutionary innovations of human cerebral cortex viewed through the lens of high-throughput sequencing [0.03%]
高通量测序技术视角下的人大脑皮层进化创新点研究
Ikuo K Suzuki
Ikuo K Suzuki
Humans had acquired a tremendously enlarged cerebral cortex containing a huge quantity and variety of cells during evolution. Such evolutionary uniqueness offers a neural basis of our cognitive innovation and human-specific features of neur...
Auguste Vadisiute,Elise Meijer,Florina Szabó et al.
Auguste Vadisiute et al.
Neural communication in the adult nervous system is mediated primarily through chemical synapses, where action potentials elicit Ca2+ signals, which trigger vesicular fusion and neurotransmitter release in the presynaptic compartment. At ea...
Alexandre Espinós,Eduardo Fernández-Ortuño,Enrico Negri et al.
Alexandre Espinós et al.
The size of the cerebral cortex increases dramatically across amniotes, from reptiles to great apes. This is primarily due to different numbers of neurons and glial cells produced during embryonic development. The evolutionary expansion of ...
Patricia R Nano,Aparna Bhaduri
Patricia R Nano
Compared with that of even the closest primates, the human cortex displays a high degree of specialization and expansion that largely emerges developmentally. Although decades of research in the mouse and other model systems has revealed co...
Transcriptomic analyses of NeuroD1-mediated astrocyte-to-neuron conversion [0.03%]
NeuroD1介导的星形胶质细胞转分化为神经元的转录组分析
Ning-Xin Ma,Brendan Puls,Gong Chen
Ning-Xin Ma
Ectopic expression of a single neural transcription factor NeuroD1 can reprogram reactive glial cells into functional neurons both in vitro and in vivo, but the underlying mechanisms are not well understood yet. Here, we used RNA-sequencing...
Lei-Lei Wang,Chun-Li Zhang
Lei-Lei Wang
Neuron loss and disruption of neural circuits are associated with many neurological conditions. A key question is how to rebuild neural circuits for functional improvements. In vivo glia-to-neuron (GtN) conversion emerges as a potential sol...
E3 ubiquitin ligases and cerebral cortex development in health and disease [0.03%]
泛素连接酶与大脑皮层的健康及疾病中的发育关系研究进展
Nicolas Lambert,Martin Moïse,Laurent Nguyen
Nicolas Lambert
Cerebral cortex development involves the sequential progression of biological steps driven by molecular pathways whose tight regulation often relies on ubiquitination. Ubiquitination is a posttranslational modification involved in all aspec...