Excitatory and inhibitory neuron imbalance in the intrauterine growth restricted fetal guinea pig brain: Relevance to the developmental origins of schizophrenia and autism [0.03%]
宫内生长受限胎 Guinea猪脑中的兴奋性和抑制性神经元不平衡：与精神分裂症和自闭症的发育起源的相关性
Angela Cumberland,Nadia Hale,Aminath Azhan et al.
Angela Cumberland et al.
Neurodevelopmental disorders such as schizophrenia and autism are thought to involve an imbalance of excitatory and inhibitory signaling in the brain. Intrauterine growth restriction (IUGR) is a risk factor for these disorders, with IUGR on...
microRNA-124 regulates Notch and NeuroD1 to mediate transition states of neuronal development [0.03%]
微小核糖核酸-124通过调节Notch和神经分化1介导神经元发育的过渡状态
Kalin D Konrad,Jia L Song
Kalin D Konrad
MicroRNAs regulate gene expression by destabilizing target mRNA and/or inhibiting translation in animal cells. The ability to mechanistically dissect miR-124's function during specification, differentiation, and maturation of neurons during...
Family income buffers the relationship between childhood adverse experiences and putamen volume [0.03%]
家庭收入缓冲了童年不良经历与尾状核体积之间的关系
Max P Herzberg,Laura Hennefield,Katherine R Luking et al.
Max P Herzberg et al.
Adverse experiences and family income in childhood have been associated with altered brain development. While there is a large body of research examining these associations, it has primarily used cross-sectional data sources and studied adv...
Microglia in motor neuron disease: Signaling evidence from last 10 years [0.03%]
过去十年运动神经元疾病小胶质细胞信号的证据总结
Min-Jia Wang,Lu Kang,Yao-Zheng Wang et al.
Min-Jia Wang et al.
Motor neuron disease (MND), including amyotrophic lateral sclerosis, spinal muscular atrophy and others, involved the upper or lower motor neurons selective loss, is characterized by neurodegeneration and neuroinflammation, in conjunction w...
Terminal field volume of the glossopharyngeal nerve in adult rats reverts to prepruning size following microglia depletion with PLX5622 [0.03%]
成年大鼠迷走神经终末场体积在小胶质细胞耗竭后的重塑作用研究（PLX5622处理）
Andrew J Riquier,Suzanne I Sollars
Andrew J Riquier
Programmed reduction of synapses is a hallmark of the developing brain, with sensory systems emerging as useful models with which to study this pruning. The central projections (terminal field) of the gustatory glossopharyngeal nerve (GL) o...
Large-scale waves of activity in the neonatal mouse brain in vivo occur almost exclusively during sleep cycles [0.03%]
活体新生小鼠大脑中的大规模活动波几乎只在睡眠周期中出现
Dennis R Tabuena,Randy Huynh,Jenna Metcalf et al.
Dennis R Tabuena et al.
Spontaneous electrical activity plays major roles in the development of cortical circuitry. This activity can occur highly localized regions or can propagate over the entire cortex. Both types of activity coexist during early development. T...
Sex differences in myelination of the zebra finch vocal control system emerge relatively late in development [0.03%]
环企鹅凤头莺鸣叫控制系统的性别差异在发育后期出现
Adriana Diez,Shenghan Wang,Nicole Carfagnini et al.
Adriana Diez et al.
The role of myelination in the development of motor control is widely known, but its role in the development of cognitive abilities is less understood. Here, we examined sex differences in the development of myelination of structures and tr...
The cortical hem lacks stem cell potential despite expressing SOX9 and HOPX [0.03%]
尽管表达SOX9和HOPX，脑皮层背侧缺乏干细胞潜能
Alessia Caramello,Christophe Galichet,Miriam Llorian Sopena et al.
Alessia Caramello et al.
The adult dentate gyrus (DG) of rodents hosts a neural stem cell (NSC) niche capable of generating new neurons throughout life. The embryonic origin and molecular mechanisms underlying formation of DG NSCs are still being investigated. We p...
Enriched environment rescues neonatal pain induced cognitive deficits and the impaired hippocampal synaptic plasticity later in life [0.03%]
enrichment environment rescues neonatal pain induced cognitive deficits and the impaired hippocampal synaptic plasticity later in life
Cuiting Min,Ru Ling,Mengying Chen et al.
Cuiting Min et al.
Although extensive and untreated pain that occurs during a critical developmental window may impair cognition later in life, environmental interventions early in life might promote cognition. However, the underlying mechanism is poorly unde...
Seon Hye E Park,Ana K Ortiz,Genevieve Konopka
Seon Hye E Park
The neocortex (or pallium) consists of diverse cell types that are organized in a highly species-specific manner under strict spatiotemporal control during development. Many of the cell types are present transiently throughout development b...