Exploring the Role of Gut Vascular Barrier Proteins in HIV-Induced Mucosal Damage: A Comparative Study [0.03%]
HIV诱导的肠粘膜损伤中血管屏障蛋白作用的研究——比较研究
Li Jin,Rong Hu,Yong Qing et al.
Li Jin et al.
This study aims to compare intestinal mucosal damage and the expression levels of occludin, zonula occludens-1 (ZO-1), vascular endothelial (VE)-cadherin, β-catenin, and plasmalemma vesicle-associated protein (PLVAP) in the gut vascular ba...
Cardiovascular Safety of Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate in Virologically Suppressed PLWHIV: A Comparative Analysis of CVD Scores [0.03%]
评估多拉韦林/拉米夫定/富马酸替诺福韦二吡呋酯在病毒学上抑制HIV感染者的PLWHIV心血管安全性：CVD评分的比较分析
Arturo Ciccullo,Valentina Iannone,Damiano Farinacci et al.
Arturo Ciccullo et al.
The Aim of this study is to assess the cardiovascular safety of doravirine/lamivudine/tenofovir disoproxil fumarate (DOR/3TC/TDF). We analyzed data from 37 virologically suppressed people living with HIV starting DOR/3TC/TDF, collecting vir...
Central Memory CD4 T Cells from Persons with HIV Accumulate DNA Content Defects During Proliferative Response [0.03%]
HIV感染者中央记忆CD4 T细胞在增殖反应中积累DNA含量缺陷
Dámaris P Romero-Rodríguez,Jessica Romero-Rodríguez,Fernanda Cervantes-Mejía et al.
Dámaris P Romero-Rodríguez et al.
Central memory (TCM) cells are a subpopulation of CD4 T cells that sustain overall CD4 T cell counts in HIV infection. The mechanisms underlying their eventual demise, which leads to loss of CD4 T cell counts, are not known. To understand t...
Comparison of the Performance of Commercially Available Quantitative Viral Load Assays Using Clinical Samples from Patients from Regions Where Distinct HIV-1 Subtypes Co-Circulate: Potential Implications for Patient Management [0.03%]
利用来自多种HIV-1亚型共循环地区的临床样本比较市售定量病毒负荷测定法的性能：对患者管理的意义探讨
Maria Cecilia Araripe Sucupira,Mauro Schechter,Adauto Castelo Filho et al.
Maria Cecilia Araripe Sucupira et al.
HIV RNA plasma viral load (VL) is the standard surrogate marker to monitor response to antiretroviral treatment (ART). We compared the linearity, repeatability, and concordance of six commercially available HIV RNA VL platforms using clinic...
HIV DNA Levels in Persons Who Acquired HIV in the Setting of Long-Acting Cabotegravir for HIV Prevention: Analysis of Cases from HPTN 083 and 084 [0.03%]
在长效卡博特格拉韦HIV预防环境中获得HIV者的HIV DNA水平：来自HPTN 083和084研究的病例分析
Jessica M Fogel,Deborah Persaud,Estelle Piwowar-Manning et al.
Jessica M Fogel et al.
We evaluated HIV DNA levels in individuals who received long-acting cabotegravir (CAB-LA) or tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) pre-exposure prophylaxis in the HPTN 083 and 084 trials and had HIV DNA testing performed to ...
"They Have to Make an Effort Too": What Decliners Can Teach Us About HIV Cure/Remission-Related Clinical Trials? Results from a French Qualitative Study [0.03%]
“他们也需要做出努力”：定性研究中法国HIV携带者对于临床试验的看法
Sarah Lefebvre,Jean-Daniel Lelièvre,Véronique Rieux et al.
Sarah Lefebvre et al.
Only one study to date has focused on people living with HIV (PLWH) who refused to participate in a HIV cure/remission-related clinical trial (HCCT)-"decliners" hereafter-that included analytical treatment interruption (ATI). Exploring why ...
Long-Term Follow-Up of Persons Living with Perinatally Acquired HIV Infection at a Large HIV Treatment Clinic in Trinidad [0.03%]
特立尼达一家大型艾滋门诊长期随访调查 perinatally HIV感染幸存者
Jonathan Edwards,Gregory Boyce,Nyla Lyons et al.
Jonathan Edwards et al.
Data on persons with perinatally acquired HIV infection in the Caribbean are limited; thus, a chart review was conducted among these clients at an adult HIV treatment clinic in Trinidad over the period January 01, 2011-June 30, 2023. Sociod...
Interpreting the Epidemiological Characteristics of HIV-1 in Heterosexually Transmitted Population Based on Molecular Transmission Network in Kunming, Yunnan: A Retrospective Cohort Study [0.03%]
基于分子传播网络的昆明市异性传播HIV-1流行病学特征解释：一项回顾性队列研究
Peng Cheng,Bao-Cui He,Zhi-Xing Wu et al.
Peng Cheng et al.
Heterosexuals have become the most prevalent group of HIV-1 in Kunming, Yunnan Province. Utilizing the principle of genetic similarity between their gene sequences, we built a molecular transmission network by gathering data from earlier mo...
A Randomized, Double-Blind, Placebo-Controlled, Short-Term Monotherapy Study of MK-6186, an HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor, in Treatment-Naïve HIV-Infected Participants [0.03%]
MK-6186（HIV-1非核苷逆转录酶抑制剂）单药治疗初治HIV感染者短期疗效的随机、双盲、安慰剂对照研究
Dirk Schürmann,Andreas Hüser,Frieder Pfäfflin et al.
Dirk Schürmann et al.
Objective: To assess the antiviral activity, pharmacokinetics, and safety of MK-6186 in HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI)-naïve, HIV-1-infected male participants. Design: Double-blind, randomized, two-panel study...
CD57+ T Cell Transmigration Through Vascular Endothelial Cells is Enhanced by Tumor Necrosis Factor: A Novel Model of Cardiovascular Risk in People with HIV [0.03%]
肿瘤坏死因子通过新的模型增强HIV患者心血管风险中的CD57+T细胞的血管内皮细胞迁移效应
Xi Su,Michael L Freeman
Xi Su
People with human immunodeficiency virus (PWH), despite achieving viral suppression through antiretroviral therapy, face increased risk and earlier onset of atherosclerotic cardiovascular diseases than the general population. CD57+ T cells ...