Mechanism of Action of San Ren Decoction in PLWH Treatment Determined Using Network Pharmacology Combined with Experimental Validation [0.03%]
基于网络药理学联合实验验证的桑仁汤治疗艾滋病作用机制研究
Juan Wang,Miao Zhang,Jiang Qicheng et al.
Juan Wang et al.
To explore the mechanism of action of San Ren Decoction (SRD) in people living with HIV (PLWH) treatment using network pharmacology, molecular docking technology, and cellular experiments. The active ingredients and potential targets of the...
Identification of a Novel HIV-1 Recombinant Form (CRF01_AE/07_BC) from an Elderly Individual in Hangzhou, Eastern China [0.03%]
在中国东部杭州市一名老年人中发现一种新型HIV-1重组株（CRF01_AE/07_BC）
Ling Ye,Ke Xu,Wenjie Luo et al.
Ling Ye et al.
The number and proportion of HIV/AIDS cases among older people in China have increased continuously and rapidly in recent years, with a more pronounced increase in males. In this study, we report a novel HIV-1 second-generation unique recom...
Identification of a Novel HIV-1 Second-Generation Circulating Recombinant Form (CRF193_0107) Among MSM in Hebei Province, China [0.03%]
在中国河北省 MSM 中发现新型 HIV-1 第二代循环重组型毒株（CRF193_0107）
Bo Zhu,Xiaorui Wang,Hanping Li et al.
Bo Zhu et al.
In China, the HIV-1 epidemic is predominantly dominated by the recombinant strains CRF01_AE and CRF07_BC. The high replication rate, error-prone reverse transcriptase, and frequent recombination events of HIV-1 have facilitated the emergenc...
Krisann K Oursler,Yan V Sun,Alicia J Lozano et al.
Krisann K Oursler et al.
DNA methylation is a hallmark of aging; yet, our understanding of epigenetic age acceleration (EAA) in relationship to frailty in people with HIV (PWH) is poor. We conducted an observational study among PWH from the Veterans Aging Cohort St...
Identification of a Novel HIV-1 Circulating Recombinant Form (CRF184_BC) Among Heterosexual Populations Along the China-Myanmar Border Region [0.03%]
在中国缅籍婚育人群中新发现一种HIV-1循环重组型(CRF184_BC)
Min Chen,Huichao Chen,Yanling Ma et al.
Min Chen et al.
The China-Myanmar border region is recognized as a hotspot for the emergence of HIV-1 recombinant forms. This study identified a novel HIV-1 circulating recombinant form (CRF) in this area, designated CRF184_BC. Near-full-length genome sequ...
Comparison of Plasma, Dried Blood Spots, and Peripheral Blood Mononuclear Cells as Biosamples for HIV-1 Genotypic Drug Resistance in a Tertiary Care Center [0.03%]
特护中心HIV-1基因型耐药性血浆、干血点和外周血单个核细胞生物样本的比较研究
Priyanka Sabu,Diviya Alex,Veena Vadhini Ramalingam et al.
Priyanka Sabu et al.
The collection, storage, and transport of plasma, the ideal specimen for HIV-1 genotyping, is plagued by technical difficulties in resource-limited settings. We aimed to compare corresponding bio-samples for HIV-1 genotypic drug resistance ...
Frequency of CCR5-Δ32, CCR2-64I, and SDF1-3'A Mutations in People with HIV Diagnoses and HIV Negative Participant in Khuzestan Province, Iran [0.03%]
伊朗胡泽斯坦省HIV感染者和HIV阴性参与者的CCR5-Δ32、CCR2-64I和SDF1-3'A突变频率调查研究
Mina Bavi,Shahram Jalilian,Mehdi Bijanzadeh et al.
Mina Bavi et al.
Human immunodeficiency virus type 1 (HIV-1) binds to CD4 receptors. Chemokine receptors such as C-C chemokine receptor type 5 (CCR5), C-C chemokine receptor type 2 (CCR2), and stromal-derived factor (SDF1) are involved in HIV cell entry, an...
HCV Genotype Distribution and Molecular Characteristics of HCV Core Domain I in Persons Living with HIV and HCV from Yunnan Province, China [0.03%]
中国云南省艾滋病和丙肝病毒合并感染人群的丙肝病毒基因型分布及其核心蛋白I区分子特征
Yantao Zhu,Junyi Liu,Lijuan Kang et al.
Yantao Zhu et al.
Yunnan Province, a critical southwestern Chinese border region and gateway to Southeast Asia, faces a complex human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infection epidemic. Molecular data on HCV Core domain I in persons l...
Psychological Impact of Analytical Treatment Interruption on Young Women Enrolled in an HIV Cure-Related Clinical Trial in Durban, South Africa [0.03%]
在南非德班进行HIV治愈相关临床试验的年轻女性中断分析治疗的心理影响
Ali Ahmed,Krista L Dong,Maryam Hussain et al.
Ali Ahmed et al.
Analytical treatment interruption (ATI) is a planned and monitored pause of ART used in HIV-related studies that enables measurement of viral rebound kinetics and immune responses, yet it may pose psychological risks to participants. Eviden...
Exploring Potential Associations Between HIV Acquisition and Biological Aging: Insights from a Bidirectional Mendelian Randomization Study [0.03%]
基于双向孟德尔随机化研究探讨HIV感染与生物衰老之间的潜在关联
Haili Wang,Hong Fan,Chengnan Guo et al.
Haili Wang et al.
Accumulating evidence indicates that HIV acquisition may be associated with premature aging. However, the causal relationship and the direction of the effect between HIV acquisition and aging remain controversial. In the present study, we a...