Conclusions [0.03%]
结论
Robert Hitzemann,Denesa Oberbeck
Robert Hitzemann
Integrative genetic analysis of alcohol dependence using the GeneNetwork Web resources [0.03%]
利用GeneNetWork网络资源进行酒精依赖的整合性基因分析
Robert W Williams,Lu Lu
Robert W Williams
Not long ago, the idea that alcoholism had a genetic basis-even in part-was highly controversial (Goodwin 1971, 1975). Over the past 35 years, however, the contribution of genetic factors has become conventional wisdom. This change to a lar...
Laura Saba,Paula L Hoffman,Cheryl Hornbaker et al.
Laura Saba et al.
Researchers from a wide variety of backgrounds and with a broad range of goals have utilized high-throughput screening technologies (i.e., microarray technologies) to identify candidate genes that may be associated with an observable charac...
Nicole A R Walter,Shannon K McWeeney,Sandra T Peters et al.
Nicole A R Walter et al.
Microarrays are widely used to evaluate gene expression at the genome scale. However, all too often the importance of data analysis at the level of the individual probe is overlooked. This is a particular problem when trying to detect diffe...
Interval-specific congenic animals for high-resolution quantitative trait loci mapping [0.03%]
适用于高精度定量性状位点定位的区间特异性共渗品系动物
Deaunne L Denmark,Lauren C Milner,Kari J Buck
Deaunne L Denmark
Behavioral phenotypes (e.g., drug responses and withdrawal) are typically quantitative traits-characteristics that differ along a spectrum in the extent to which an individual possesses that characteristic. Such traits are determined by mul...
Quantitative trait locus analysis: multiple cross and heterogeneous stock mapping [0.03%]
数量性状基因定位分析：多交配组合和非纯种系谱图绘制法
Robert Hitzemann,John K Belknap,Shannon K McWeeney
Robert Hitzemann
Until well into the 1990s, both preclinical and clinical research focused on finding "the" gene for human diseases, including alcoholism. This focus was reinforced by the emergence of technologies to either inactivate (i.e., knock out) a ge...
Viral delivery of small-hairpin RNAs for reducing gene expression in the rodent brain [0.03%]
利用病毒转导的小发卡RNA降低啮齿动物脑内的基因表达
Amy W Lasek,Ulrike Heberlein
Amy W Lasek
This article reviews a strategy to ensure long-term expression of a type of interfering RNA molecule-small-hairpin RNAs (shRNAs)-through the use of viral delivery systems (i.e., vectors). Expression of these shRNAs leads to the destruction ...
Christopher A Adams,W Michael Zawada
Christopher A Adams
One strategy to determine the contribution of individual genes to the development of complex traits and behaviors such as alcohol consumption is to reduce or completely eliminate the activity of those genes in the cells or organism under in...
Proteomic solutions for analytical challenges associated with alcohol research [0.03%]
与酒精研究相关的分析挑战的蛋白质组学解决方案
Michael J MacCoss,Christine C Wu
Michael J MacCoss
Alcohol addiction is a complex disease with both hereditary and environmental influences. Because molecular determinants contributing to this phenotype are difficult to study in humans, numerous rodent models and conditioning paradigms have...
Denesa Oberbeck
Denesa Oberbeck
When analyzing alcohol's effects on the brain, researchers often want to look at small clusters of cells that can be studied in isolation from the surrounding brain tissue rather than at the entire brain or larger brain areas. This implies ...